Cytotoxic Secondary Metabolites from the Endolichenic Fungus Hypoxylon fuscum

Buddha Bahadur Basnet; Baosong Chen; Yerlan Melsuly Suleimen; Ke Ma; Shouyu Guo; Li Bao; Ying Huang; Hongwei Liu

doi:10.1055/a-0957-3567

Planta Medica, Table of Contents

Planta Med 2019; 85(13): 1088-1097
DOI: 10.1055/a-0957-3567

Natural Product Chemistry and Analytical Studies

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Secondary Metabolites from the Endolichenic Fungus Hypoxylon fuscum

Buddha Bahadur Basnet‡

¹State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, China

²International College, University of Chinese Academy of Sciences, Beijing, China

,

Baosong Chen‡

¹State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, China

³Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China

,

Yerlan Melsuly Suleimen

¹State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, China

⁴Institute of Applied Chemistry, Chemistry Department of L. N. Gumilyov Eurasian National University, Astana, the Republic of Kazakhstan

,

Ke Ma

¹State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, China

³Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China

,

Shouyu Guo

¹State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, China

,

Li Bao

¹State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, China

³Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China

,

Ying Huang

⁵State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences. No. 1 Beichenxi Road, Chaoyang District, Beijing, P. R. China

,

Hongwei Liu

¹State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, China

³Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China

› Author Affiliations

Abstract

As part of our search for new cytotoxic and antimicrobial natural products from endolichenic fungi, 19 compounds including 1 new 10-member lactone (2), 1 new polyacetylene glycoside (3), 1 new brasilane-type sesquiterpenoid glycoside (4), and 2 isobenzofuran-1(3H)-one derivatives (5 and 6) were isolated from the solid culture of the endolichenic fungus Hypoxylon fuscum. Their structures were unambiguously elucidated by NMR spectroscopic data, MS, ECD (electronic circular dichroism) calculation, and chemical methods. The cytotoxic effects on K562, SW480, and HEPG2 cell lines and the antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Candida albicans were assessed. Compounds 1, 2, and 5 exhibited moderate cytotoxicity against K562, SW480, and HEPG2 cell lines while compounds 1, 9, and 11 displayed weak antibacterial activity against S. aureus.

Key words

Hypoxylon fuscum - Hypoxylaceae - endolichenic fungi - polyacetylene - sesquiterpene - cytotoxicity - antimicrobial activity

Full Text

References

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