Hippocampal Dysfunction in Schizophrenia and Aberrant Hippocampal
                    Synaptic Plasticity in Rodent Model Psychosis: a Selective
                    Review

Julia C. Bartsch; Björn H. Schott; Joachim Behr

doi:10.1055/a-0960-9846

Pharmacopsychiatry, Table of Contents

Pharmacopsychiatry 2023; 56(02): 57-63
DOI: 10.1055/a-0960-9846

Review

Hippocampal Dysfunction in Schizophrenia and Aberrant Hippocampal Synaptic Plasticity in Rodent Model Psychosis: a Selective Review^[1]

Julia C. Bartsch

¹Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany

²Institute of Physiology I, Westfälische Wilhelms-Universität Münster, Münster, Germany

,

Björn H. Schott

¹Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany

³Leibniz Institute for Neurobiology, Magdeburg, Germany

⁴Department of Psychiatry and Psychotherapy, University Medicine Göttingen, Germany

,

Joachim Behr

¹Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany

⁵Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Brandenburg Medical School, Neuruppin, Germany

› Author Affiliations

Abstract

Schizophrenia is a complex, heterogeneous psychiatric disorder that affects about 1% of the global population. Hippocampal dysfunction has been linked to both cognitive deficits and positive symptoms in schizophrenia. Here, we briefly review current findings on disrupted hippocampal processing from a clinical perspective before concentrating on preclinical studies of aberrant hippocampal synaptic plasticity using the N-methyl-D-aspartate receptor hypofunction model of psychosis and related findings from genetic models. Taken together, the results put the case for maladaptive hippocampal synaptic plasticity and its extrinsic connections as mechanistic underpinnings of cognitive impairments in schizophrenia.

Key words

schizophrenia - hippocampus - synaptic plasticity - dopamine - long-term potentiation

Full Text

References

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Hippocampal Dysfunction in Schizophrenia and Aberrant Hippocampal Synaptic Plasticity in Rodent Model Psychosis: a Selective Review[1]

Hippocampal Dysfunction in Schizophrenia and Aberrant Hippocampal Synaptic Plasticity in Rodent Model Psychosis: a Selective Review^[1]