Pathologisch-genetisch orientierte Diabetes-Reklassifizierung

Abstract

Diabetes mellitus has been defined by hyperglycemia, but in addition to hyperglycemia, there are several other factors determining the clinical course and complications. We review the current classification of diabetes and recent attempts to identify new subphenotypes. Notably, there are anthropometry-pathophysiology based and genome-based subphenotyping approaches. They aim to improve the prediction of disease course and complications and could pave the way for precision medicine in the therapy of diabetes.

Die pathologisch-genetisch orientierte Reklassifizierung des Diabetes-Krankheitsspektrums liefert die Basis für eine Präzisionsmedizin, deren Konzept eine auf den einzelnen Patienten zugeschnittene Therapie zum Ziel hat. Die unterschiedlichen Subphänotypen des Diabetes mellitus könnten durch Präzisionsmedizin wahrscheinlich besser behandelt werden. Entsprechende Einteilungen wurden nun vorgelegt.

Schlüsselwörter

Insulinresistenz - Endokrinologie - Diabetes mellitus - targeted Therapy - personalisierte Medizin - Suphänotypisierung - Klassifikation - Cluster - Pathophysiologie - Genetik

Key words

diabetes - type 2 diabetes - insulin resistance - insulin secretion - personalised medicine - precision medicine - subphenotyping - classification - clustering - pathophysiology - genetics

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