Aphereseverfahren bei Autoimmunerkrankungen

ZUSAMMENFASSUNG

Aphereseverfahren finden neben ihrem etablierten Einsatz in derTransplantations- und Transfusionsmedizin vor allem in der Therapie autoimmunologischer entzündlich-rheumatischer und neurologischer Erkrankungen zunehmende klinische Anwendung. Ihre grundsätzliche Funktionsweise liegt im Entzug pathophysiologisch wirksamer Blutbestandteile (v. a. IgG-Antikörper) und weiteren immunmodulatorischen Effekten. Mögliche Apheresemodalitäten sind die unselektive Plasmapherese mit nachfolgendem Ersatz des entzogenen Plasmas durch verschiedenartige Substituate sowie die selektivere Immunadsorption. Die Therapie ist logistisch aufwendig, jedoch für den Patienten nebenwirkungsarm.

• Literatur

• 1 Winters JL. Plasma exchange: concepts, mechanisms, and an overview of the American Society for Apheresis guidelines. Hematology Am Soc Hematol Educ Program 2012; 2012: 7-12
• 2 Renders L, Wen M, Küchle C. Plasmapherese und Immunadsorption. Der Nephrologe 2014; 9: 284-292
• 3 Koessler J, Kobsar A, Kuhn S. et al The effect of immunoadsorption with the Immusorba TR-350 column on coagulation compared to plasma exchange. Vox Sang 2015; 108: 46-51
• 4 Orlando G, Remuzzi G, Williams DF. Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era. Elsevier Science; 2017
• 5 Golestaneh L, Mokrzycki MH. Vascular access in therapeutic apheresis: update, 2013. J Clin Apher 2013; 28: 64-72
• 6 Tsuboi Y, Takahashi M, Ishikawa Y. et al Elevated bradykinin and decreased carboxypeptidase R as a cause of hypotension during tryptophan column immunoabsorption therapy. Ther Apher 1998; 2: 297-299
• 7 Schwartz J, Padmanabhan A, Aqui N. et al Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence-Based Approach from the Writing Committee of the American Society for Apheresis: The Seventh Special Issue. J Clin Apher 2016; 31: 149-162
• 8 Faissner S, Nikolayczik J, Chan A. et al Immunoadsorption in patients with neuromyelitis optica spectrum disorder. Ther Adv Neurol Disord 2016; 9: 281-286
• 9 Schneider-Gold C, Krenzer M, Klinker E. et al Immunoadsorption versus plasma exchange versus combination for treatment of myasthenic deterioration. Ther Adv Neurol Disord 2016; 9: 297-303
• 10 Lockwood CM, Rees AJ, Pearson TA. et al Immunosuppression and plasma-exchange in the treatment of Goodpasture‘s syndrome. Lancet 1976; 1: 711-715
• 11 Johnson JP, Moore JR J, Austin H. A3 et al Therapy of anti-glomerular basement membrane antibody disease: analysis of prognostic significance of clinical, pathologic and treatment factors. Medicine (Baltimore) 1985; 64: 219-227
• 12 Biesenbach P, Kain R, Derfler K. et al Long-term outcome of anti-glomerular basement membrane antibody disease treated with immunoadsorption. PLoS One 2014; 9: e103568
• 13 Jayne DRW, Gaskin G, Rasmussen N. et al Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis. J Am Soc Nephrol 2007; 18: 2180-2188
• 14 Walsh M, Casian A, Flossmann O. et al Long-term follow-up of patients with severe ANCA-associated vasculitis comparing plasma exchange to intravenous methylprednisolone treatment is unclear. Kidney Int 2013; 84: 397-402
• 15 Walsh M. Late breaking clinical trials. 55 rd ERA-EDTA CONGRESS COPENHAGEN DENMARK – May 24th–27th, 2018. Daily Congress Newspaper 2018; 3: 1
• 16 Cartin-Ceba R, Diaz-Caballero L, Al-Qadi MO. et al Diffuse Alveolar Hemorrhage Secondary to Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Predictors of Respiratory Failure and Clinical Outcomes. Arthritis Rheumatol 2016; 68: 1467-1476
• 17 Cacoub P, Comarmond C, Domont F. et al Cryoglobulinemia Vasculitis. Am J Med 2015; 128: 950-955
• 18 Yu X, Zhang L, Wang L. et al MRI assessment of erosion repair in patients with long-standing rheumatoid arthritis receiving double-filtration plasmapheresis in addition to leflunomide and methotrexate: a randomized controlled trial. Clin Rheumatol 2018; 37: 917-925
• 19 Kronbichler A, Brezina B, Quintana LF, Jayne DRW. Efficacy of plasma exchange and immunoadsorption in systemic lupus erythematosus and antiphospholipid syndrome: A systematic review. Vol. 1. Netherlands: 2016. Jan
• 20 Danieli MG, Palmieri C, Salvi A. et al Synchronised therapy and high-dose cyclophosphamide in proliferative lupus nephritis. J Clin Apher 2002; 17: 72-77
• 21 Stummvoll GH, Schmaldienst S, Smolen JS. et al Lupus nephritis: prolonged immunoadsorption (IAS) reduces proteinuria and stabilizes global disease activity. Nephrol Dial Transplant 2012; 27: 618-626
• 22 Yuki N, Susuki K, Koga M. et al Carbohydrate mimicry between human ganglioside GM1 and Campylobacter jejuni lipooligosaccharide causes Guillain-Barre syndrome. Proc Natl Acad Sci U S A 2004; 101: 11404-11409
• 23 Stoll G, Reiners K. Immune-mediated neuropathies. Nervenarzt 2016; 87: 887-898
• 24 Cortese I, Chaudhry V, So YT. et al Evidence-based guideline update: Plasmapheresis in neurologic disorders: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2011; 76: 294-300
• 25 Marn Pernat A, Buturovic-Ponikvar J, Svigelj V. et al Guillain-Barre syndrome treated by membrane plasma exchange and/or immunoadsorption. Ther Apher Dial 2009; 13: 310-313
• 26 Fokke C, van den Berg B, Drenthen J. et al Diagnosis of Guillain-Barre syndrome and validation of Brighton criteria. Brain 2014; 137: 33-43
• 27 Galldiks N, Burghaus L, Dohmen C. et al Immunoadsorption in patients with chronic inflammatory demyelinating polyradiculoneuropathy with unsatisfactory response to first-line treatment. Eur Neurol 2011; 66: 183-189
• 28 Lieker I, Slowinski T, Harms L. et al A prospective study comparing tryptophan immunoadsorption with therapeutic plasma exchange for the treatment of chronic inflammatory demyelinating polyneuropathy. J Clin Apher 2017; 32: 486-493
• 29 Gilhus NE. Myasthenia Gravis. N Engl J Med 2016; 375: 2570-2581
• 30 Kohler W, Bucka C, Klingel R. A randomized and controlled study comparing immunoadsorption and plasma exchange in myasthenic crisis. J Clin Apher 2011; 26: 347-355
• 31 Grob D, Simpson D, Mitsumoto H. et al Treatment of myasthenia gravis by immunoadsorption of plasma. Neurology 1995; 45: 338-344
• 32 Liew WKM, Powell CA, Sloan SR. et al Comparison of plasmapheresis and intravenous immunoglobulin as maintenance therapies for juvenile myasthenia gravis. JAMA Neurol 2014; 71: 575-580
• 33 Gajdos P, Chevret S, Clair B. et al Clinical trial of plasma exchange and high-dose intravenous immunoglobulin in myasthenia gravis. Myasthenia Gravis Clinical Study Group. Ann Neurol 1997; 41: 789-796
• 34 Noseworthy JH, Lucchinetti C, Rodriguez M. et al Multiple sclerosis. N Engl J Med 2000; 343: 938-952
• 35 Gold R. Diagnose und Therapie der Multiplen Sklerose. In Diener H-C, Weimar C Hrsg. Leitlinien für Diagnostik und Therapie in der Neurologie. Stuttgart: Thieme; 2012
• 36 Faissner S, Nikolayczik J, Chan A. et al Plasmapheresis and immunoadsorption in patients with steroid refractory multiple sclerosis relapses. J Neurol 2016; 263: 1092-1098
• 37 Park-Wyllie L, Mazzotta P, Pastuszak A. et al Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratology 2000; 62: 385-392
• 38 Hoffmann F, Kraft A, Heigl F. et al Tryptophan immunoadsorption during pregnancy and breastfeeding in patients with acute relapse of multiple sclerosis and neuromyelitis optica. Ther Adv Neurol Disord 2018; 11: 1756286418774973
• 39 Cox JL, Koepsell SA, Shunkwiler SM. Therapeutic plasma exchange and pregnancy: A case report and guidelines for performing plasma exchange in a pregnant patient. J Clin Apher 2017; 32: 191-195
• 40 Wingerchuk DM, Lennon VA, Lucchinetti CF. et al The spectrum of neuromyelitis optica. Lancet Neurol 2007; 6: 805-815
• 41 Kim S-H, Kim W, Huh S-Y. et al Clinical efficacy of plasmapheresis in patients with neuromyelitis optica spectrum disorder and effects on circulating anti-aquaporin-4 antibody levels. J Clin Neurol 2013; 9: 36-42
• 42 Dalmau J, Tüzün E, Wu H. et al Paraneoplastic Anti-N-methyl-D-aspartate Receptor Encephalitis Associated with Ovarian Teratoma. Ann Neurol 2007; 61: 25-36