Neurologie up2date, Table of Contents Neurologie up2date 2020; 3(03): 299-314DOI: 10.1055/a-0997-1868 Schlafstörungen Insomnie im Rahmen neurologischer Erkrankungen Moritz D. Brandt Recommend Article Abstract Buy Article All articles of this category Der Artikel liefert einen Überblick über die Prävalenz, Ursache und Behandlung der Insomnie im Rahmen häufiger neurologischer Erkrankungen (Restless-Legs-Syndrom, Schlaganfall, Multiple Sklerose, Morbus Parkinson und Alzheimer-Demenz). Zudem wird auf die wechselseitigen kausalen Zusammenhänge zwischen Schlafstörungen und neurologischen Erkrankungen hingewiesen. Full Text References Literatur 1 Riemann D, Baum E, Cohrs S. et al. S3 Leitlinie Nicht erholsamer Schlaf/Schlafstörungen. AWMF-Registernummer 063–001, Kap „Insomnie bei Erwachsenen“. Somnologie 2017; 20 (Suppl. 02) S97-S180 Im Internet: (Stand: 12.06.2020) https://www.dgsm.de/downloads/aktuelles/S3%20LL%20Nicht-erholsamer%20Schlaf%20Kap%20SBAS%2011818_20_s2_2017.pdf 2 Allen RP, Picchietti DL, Garcia-Borreguero D. et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria -- history, rationale, description, and significance. International Restless Legs Syndrome Study Group. Sleep Med 2014; 15: 860-873 3 Winkelmann J, Allen RP, Högl B. et al. Treatment of restless legs syndrome: Evidence-based review and implications for clinical practice. Mov Disord 2018; 33: 1077-1091 4 Loke YK, Brown JW, Kwok CS. et al. Association of obstructive sleep apnea with risk of serious cardiovascular events: a systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes 2012; 5: 720-728 5 Glozier N, Moullaali TJ, Sivertsen B. et al. The course and impact of poststroke insomnia in stroke survivors aged 18 to 65 years: Results from the Psychosocial Outcomes In StrokE (POISE) Study. Cerebrovasc Dis Extra 2017; 7: 9-20 6 Helbig AK, Stöckl D, Heier M. et al. Symptoms of Insomnia and Sleep Duration and Their Association with Incident Strokes: Findings from the Population-Based MONICA/KORA Augsburg Cohort Study. PLoS One 2015; 10: e0134480 7 Sahraian MA, Rezaali S, Hosseiny M. et al. Sleep disorder as a triggering factor for relapse in multiple sclerosis. Eur Neurol 2017; 77: 258-261 8 Bellesi M, Pfister-Genskow M, Maret S. et al. Effects of sleep and wake on oligodendrocytes and their precursors. J Neurosci 2013; 33: 14288-14300 9 Hedström AK, Åkerstedt T, Hillert J. et al. Shift work at young age is associated with increased risk for multiple sclerosis. Ann Neurol 2011; 70: 733-741 10 Schrempf W, Brandt MD, Storch A. et al. Sleep disorders in Parkinson's disease. J Parkinsons Dis 2014; 4: 211-221 11 Choi JH, Kim HJ, Lee JY. et al. Long-term effects of bilateral subthalamic nucleus stimulation on sleep in patients with Parkinson’s disease. PLoS One 2019; 14: e0221219 12 Postuma RB, Iranzo A, Hu M. et al. Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study. Brain 2019; 142: 744-759 13 McKeith IG, Boeve BF, Dickson DW. et al. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology 2017; 89: 88-100 14 Lysen TS, Darweesh SKL, Ikram MK. et al. Sleep and risk of parkinsonism and Parkinsonʼs disease: a population-based study. Brain 2019; 142: 2013-2022 15 Lim AS, Ellison BA, Wang JL. et al. Sleep is related to neuron numbers in the ventrolateral preoptic/intermediate nucleus in older adults with and without Alzheimer's disease. Brain 2014; 137: 2847-2861 16 McCleery J, Cohen DA, Sharpley AL. Pharmacotherapies for sleep disturbances in Alzheimerʼs disease. Cochrane Database Syst Rev 2014; CD009178 17 La AL, Walsh CM, Neylan TC. et al. Long-term trazodone use and cognition: a potential therapeutic role for slow-wave sleep enhancers. J Alzheimers Dis 2019; 67: 911-921 18 Lim AS, Yu L, Kowgier M. et al. Modification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep. JAMA Neurol 2013; 70: 1544-1551 19 Xie L, Kang H, Xu Q. et al. Sleep drives metabolite clearence from the adult brain. Science 2013; 342 : 373-377 20 Spira AP, Gamaldo AA, An Y. et al. Self-reported sleep and β-amyloid deposition in community-dwelling older adults. JAMA Neurol 2013; 70: 1537-1543