Definition, Classification and Diagnosis of Diabetes Mellitus^[*]

Definition of Diabetes Mellitus

Diabetes mellitus is the collective term for heterogeneous metabolic disorders whose main finding is chronic hyperglycaemia. The cause is either a disturbed insulin secretion or a disturbed insulin effect or usually both.

^* The team of authors has written the practical recommendation for the Commission for Laboratory Diagnostics in Diabetology/Kommission Labordiagnostik in der Diabetologie of the German Diabetes Society/Deutsche Diabetes Gesellschaft (DDG) and the German Society for Clinical Chemistry and Laboratory Medicine (DGKL)/ Deutschen Gesellschaft für Klinische Chemie und Laboratoriumsmedizin.

• References

• 1 Deutsche Diabetes Gesellschaft und Deutsche Gesellschaft für Gynäkologie und Geburtshilfe, (Hrsg.) S3-Leitlinie Gestationsdiabetes mellitus (GDM), Diagnostik, Therapie und Nachsorge. AWMF-Registernummer: 057-008. 2018; 2. Auflage https://www.awmf.org/uploads/tx_szleitlinien/ 057-008l_S3_Gestationsdiabetes-mellitus-GDM-Diagnostik-Therapie- Nachsorge_2019-06.pdf Stand: 14.08.2019
• 2 Buzzetti R, Zampetti S, Maddaloni E. et al. Adult-onset autoimmune diabetes: Current knowledge and implications for management. Nat Rev Endocrinol 2017; 13: 674-686
• 3 Badenhoop K. MODY und andere monogenetische Diabetesformen. Diabetologe 2017; 13: 453-463
• 4 Bojunga J, Schlereth F. Type 3c diabetes mellitus-prevalence, diagnosis, special aspects of treatment. Diabetologe 2018; 14: 269-277
• 5 „Richtlinie der Bundesärztekammer zur Qualitätssicherung laboratori- umsmedizinischer Untersuchungen“. Dtsch Arztebl International. 2013 110. 1822
• 6 Masuch A. et al. Preventing misdiagnosis of diabetes in the elderly: Age- dependent HbA1c reference intervals derived from two population-ba- sed study cohorts. BMC Endocr Disord 2019; 19: 20
• 7 Ziegler AG. et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 2013; 309: 2473-2479
• 8 Kufeldt J. et al. Prevalence and distribution of diabetes mellitus in a maximum care hospital: Urgent need for HbA1c-screening. Exp Clin Endocrinol Diabetes 2018; 126: 123-129
• 9 Ahlqvist E. et al. Novel subgroups of adult-onset diabetes and their association with outcomes: A data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol 2018; 6: 361-369
• 10 Zaharia OP. German Diabetes Study Group et al Risk of diabetes-asso- ciated diseases in subgroups of patients with recent-onset diabetes: A 5-year follow-up study. Lancet Diabetes Endocrinol. 2019
• 11 Ziegler AG. et al. Oral insulin therapy for primary prevention of type 1 diabetes in infants with high genetic risk: The GPPAD-POInT (global platform for the prevention of autoimmune diabetes primary oral insulin trial) study protocol. BMJ Open 2019; 9 (06) e028578 .