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Tierarztl Prax Ausg K Kleintiere Heimtiere 2019; 47(06): 425-438
DOI: 10.1055/a-1035-9649
Übersichtsartikel / Review Article
© Georg Thieme Verlag KG Stuttgart · New York

Updates on practical ABC blood compatibility testing in cats

Avoiding acute hemolytic transfusion reactions and neonatal isoerythrolysis Article in several languages: deutsch | English
Alexandra Kehl
1   Laboklin GmbH & Co. KG, Bad Kissingen
,
Laura Truchet
1   Laboklin GmbH & Co. KG, Bad Kissingen
,
Ines Langbein-Detsch
1   Laboklin GmbH & Co. KG, Bad Kissingen
,
Elisabeth Müller
1   Laboklin GmbH & Co. KG, Bad Kissingen
,
Urs Giger
2   Section of Medical Genetics (PennGen), University of Pennsylvania, USA
› Author Affiliations
Further Information

Publication History

30 August 2019

21 October 2019

Publication Date:
06 December 2019 (online)

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Abstract

In feline practice, blood groups were considered unimportant until the 1980s. Since then much has been learned. The most important blood group system in cats is the AB (renamed here as ABC) blood group system consisting of blood types A, B and AB (better referred to as C). Type B cats have strong anti-A alloantibodies potentially leading to incompatibility reactions during A-B mismatched transfusions or neonatal isoerythrolysis (NI) in type A and C (AB) kittens born to type B queens. Acute hemolytic transfusion reactions as well as NI have been clinically well documented in cats. Immunological and genetic tests have been established and blood typing and crossmatching test kits have become commercially available. This review updates the current knowledge of these blood types, their genetics, associated incompatibility reactions, and different diagnostic tools for avoiding such reactions in clinical practice.

Key words

Feline - blood type - crossmatch testing - alloantibody - anemia - hemolysis of newborn
 

  • Literatur / References

  • 1 Auer L, Bell K, Coates S. Blood transfusion reactions in the cat. J Am Vet Med Assoc 1982; 180 (07) 729-730
    PubMedGoogle Scholar
  • 2 Giger U. Blood typing and crossmatching to ensure blood compatibility. In: Bonagura JD, Twedt DC. eds. Kirk’s Current Veterinary Therapy. XV ed.. Missouri: St. Louis; 2014: 143
    Google Scholar
  • 3 Giger U, Bücheler J. Transfusion of type-A and type-B blood to cats. J Am Vet Med Assoc 1991; 198 (03) 411-418
    PubMedGoogle Scholar
  • 4 Kehl A, Heimberger K, Langbein-Detsch I. et al. Molecular characterization of blood type A, B, and C (AB) in domestic cats and a CMAH genotyping scheme. PLoS One 2018; 13 (09) e0204287
    CrossrefPubMedGoogle Scholar
  • 5 Spada E, Miglio A, Proverbio D. et al. Signalment and blood types in cats being evaluated as blood donors at two italian university blood banks. Vet Med Int 2014; 2014: 704836
    PubMedGoogle Scholar
  • 6 Gandolfi B, Grahn RA, Gustafson NA. et al. A novel variant in CMAH is associated with blood type AB in Ragdoll cats. PLoS One 2016; 11 (05) e0154973
    CrossrefPubMedGoogle Scholar
  • 7 Kehl A, Mueller E, Giger U. CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats. Anim Genet 2019; 50 (03) 303-306
    CrossrefPubMedGoogle Scholar
  • 8 Proverbio D, Spada E, Perego R. et al. Assessment of blood types of Ragdoll cats for transfusion purposes. Vet Clin Pathol 2013; 42 (02) 157-162
    CrossrefPubMedGoogle Scholar
  • 9 Tasker S, Barker EN, Day MJ. et al. Feline blood genotyping versus phenotyping, and detection of non-AB blood type incompatibilities in UK cats. J Small Anim Pract 2014; 55 (04) 185-189
    CrossrefPubMedGoogle Scholar
  • 10 Forcada Y, Guitian J, Gibson G. Frequencies of feline blood types at a referral hospital in the south east of England. J Small Anim Pract 2007; 48 (10) 570-573
    CrossrefPubMedGoogle Scholar
  • 11 Vieira SM, Ferreira RRF, de Matos AJ. et al. Distribution of feline AB blood types: a review of frequencies and its implications in the Iberian Peninsula. JFMS Open Rep 2017; 3 (02) 2055116917727693
    PubMedGoogle Scholar
  • 12 Weinstein NM, Blais MC, Harris K. et al. A newly recognized blood group in domestic shorthair cats: the Mik red cell antigen. J Vet Intern Med 2007; 21 (02) 287-292
    CrossrefPubMedGoogle Scholar
  • 13 McClosky ME, Cimino Brown D, Weinstein NM. et al. Prevalence of naturally occurring non-AB blood type incompatibilities in cats and influence of crossmatch on transfusion outcomes. J Vet Intern Med 2018; 32 (06) 1934-1942
    CrossrefPubMedGoogle Scholar
  • 14 Bovens C, Gruffydd-Jones T. Xenotransfusion with canine blood in the feline species: review of the literature. J Feline Med Surg 2013; 15 (02) 62-67
    CrossrefPubMedGoogle Scholar
  • 15 Euler CC, Raj K, Mizukami K. et al. Xenotransfusion of anemic cats with blood compatibility issues: pre- and posttransfusion laboratory diagnostic and crossmatching studies. Vet Clin Pathol 2016; 45 (02) 244-253
    CrossrefPubMedGoogle Scholar
  • 16 Griot-Wenk ME, Callan MB, Casal ML. et al. Blood type AB in the feline AB blood group system. Am J Vet Res 1996; 57 (10) 1438-1442
    PubMedGoogle Scholar
  • 17 Giger U, Bucheler J, Patterson DF. Frequency and inheritance of A and B blood types in feline breeds of the United States. J Hered 1991; 82 (01) 15-20
    CrossrefPubMedGoogle Scholar
  • 18 Griot-Wenk ME, Giger U. Feline transfusion medicine. Blood types and their clinical importance. Vet Clin North Am Small Anim Pract 1995; 25 (06) 1305-1322
    CrossrefPubMedGoogle Scholar
  • 19 Griot-Wenk M, Pahlsson P, Chisholm-Chait A. et al. Biochemical characterization of the feline AB blood group system. Anim Genet 1993; 24 (06) 401-407
    PubMedGoogle Scholar
  • 20 Bighignoli B, Niini T, Grahn RA. et al. Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domestic cat AB blood group. BMC Genet 2007; 8: 27
    PubMedGoogle Scholar
  • 21 Omi T, Nakazawa S, Udagawa C. et al. Molecular characterization of the cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) gene associated with the feline AB blood group system. PLoS One 2016; 11 (10) e0165000
    CrossrefPubMedGoogle Scholar
  • 22 Bücheler J, Giger U. Alloantibodies against A and B blood types in cats. Vet Immunol Immunopathol 1993; 38 (03/04) 283-295
    CrossrefPubMedGoogle Scholar
  • 23 Giger U, Akol KG. Acute hemolytic transfusion reaction in an Abyssinian cat with blood type B. J Vet Intern Med 1990; 4 (06) 315-316
    CrossrefPubMedGoogle Scholar
  • 24 Niggemeier A, Haberstroh HF, Nelson VE. et al. An accidental transfusion of a type A kitten with type B blood causes a transient switch from blood type A to B. J Vet Intern Med 2000; 14 (02) 214-216
    CrossrefPubMedGoogle Scholar
  • 25 Koenig A, Maglaras Ryan C, Giger U. Acute hemolytic reaction due to A-B mismatched transfusion on a cat: transient AB blood type and blood compatibility testing results. J Vet Emerg Crit Care. (in press)
    PubMedGoogle Scholar
  • 26 Casal ML, Jezyk PF, Giger U. Transfer of colostral antibodies from queens to their kittens. Am J Vet Res 1996; 57 (11) 1653-1658
    PubMedGoogle Scholar
  • 27 Giger U, Casal ML. Feline colostrum – friend or foe: maternal antibodies in queens and kittens. J Reprod Fertil Suppl 1997; 51: 313-316
    PubMedGoogle Scholar
  • 28 Hubler M, Kaelin S, Hagen A. et al. Feline neonatal isoerythrolysis in two litters. J Small Anim Pract 1987; 28 (09) 833-838
    CrossrefPubMedGoogle Scholar
  • 29 Silvestre-Ferreira AC, Pastor J. Feline neonatal isoerythrolysis and the importance of feline blood types. Vet Med Int 2010; 2010: 753726
    PubMedGoogle Scholar
  • 30 Axnér E. A questionnaire on survival of kittens depending on the blood groups of the parents. J Feline Med Surg 2014; 16 (10) 781-787
    CrossrefPubMedGoogle Scholar
  • 31 Priolo V, Masucci M, Spada E. et al. Naturally occurring antibodies in cats against dog erythrocyte antigens and vice versa. J Feline Med Surg 2018; 20 (08) 690-695
    CrossrefPubMedGoogle Scholar
  • 32 Reid ME, Denomme GA. DNA-based methods in the immunohematology reference laboratory. Transfus Apher Sci 2011; 44 (01) 65-72
    CrossrefPubMedGoogle Scholar
  • 33 El-Sayed YS, Mohamed OI, Ashry KM. et al. Using species-specific repeat and PCR-RFLP in typing of DNA derived from blood of human and animal species. Forensic Sci Med Pathol 2010; 6 (03) 158-164
    CrossrefPubMedGoogle Scholar
  • 34 Sylvane B, Prittie J, Hohenhaus AE. et al. Effect of cross-match on packed cell volume after transfusion of packed red blood cells in transfusion-naïve anemic cats. J Vet Intern Med 2018; 32 (03) 1077-1083
    CrossrefPubMedGoogle Scholar
  • 35 Stieger K, Palos H, Giger U. Comparison of various blood-typing methods for the feline AB blood group system. Am J Vet Res 2005; 66 (08) 1393-1399
    CrossrefPubMedGoogle Scholar
  • 36 Seth M, Jackson KV, Winzelberg S. et al. Comparison of gel column, card, and cartridge techniques for dog erythrocyte antigen 1.1 blood typing. Am J Vet Res 2012; 73 (02) 213-219
    CrossrefPubMedGoogle Scholar
  • 37 Seth M, Jackson KV, Giger U. Comparison of five blood-typing methods for the feline AB blood group system. Am J Vet Res 2011; 72 (02) 203-209
    CrossrefPubMedGoogle Scholar
  • 38 Spada E, Proverbio D, Baggiani L. et al. Evaluation of an immunochromatographic test for feline AB system blood typing. J Vet Emerg Crit Care (San Antonio) 2016; 26 (01) 137-141
    CrossrefPubMedGoogle Scholar
  • 39 Hourani L, Weingart C, Kohn B. Evaluation of a novel feline AB blood typing device. J Feline Med Surg 2014; 16 (10) 826-831
    CrossrefPubMedGoogle Scholar
  • 40 Proverbio D, Spada E, Baggiani L. et al. Assessment of a gel column technique for feline blood typing. Vet Res Commun 2009; 33 (Suppl. 01) 201-203
    CrossrefPubMedGoogle Scholar
  • 41 Leidinger J, Leidinger E, Giger U. Verteilung und Bedeutung der Blutgruppen A und B bei Haus- und Rassekatzen in Oesterreich. Wien Tierärztl Monatsschr 1993; 80: 10-14
    PubMedGoogle Scholar
  • 42 Jensen AL, Olesen AB, Arnbjerg J. Distribution of feline blood types detected in the Copenhagen area of Denmark. Acta Vet Scand 1994; 35 (02) 121-124
    CrossrefPubMedGoogle Scholar
  • 43 Barrot A, Buttin R, Linsart A. et al. Frequency of feline blood types in non-pedigree cats in France. Rev Med Vet 2017; 168: 235-240
    PubMedGoogle Scholar
  • 44 Haarer M, Grünbaum EG. [Blood group typing in the cat]. Tierarztl Prax 1993; 21 (04) 339-343
    PubMedGoogle Scholar
  • 45 Mylonakis ME, Koutinas AF, Saridomichelakis M. et al. Determination of the prevalence of blood types in the non-pedigree feline population in Greece. Vet Rec 2001; 149 (07) 213-214
    CrossrefPubMedGoogle Scholar
  • 46 Bagdi N, Magdus M, Leidinger E. et al. Frequencies of feline blood types in Hungary. Acta Vet Hung 2001; 49 (04) 369-375
    CrossrefPubMedGoogle Scholar
  • 47 Juvet F, Brennan S, Mooney CT. Assessment of feline blood for transfusion purposes in the Dublin area of Ireland. Vet Rec 2011; 168 (13) 352
    CrossrefPubMedGoogle Scholar
  • 48 Proverbio D, Spada E, Baggiani L. et al. Comparison of gel column agglutination with monoclonal antibodies and card agglutination methods for assessing the feline AB group system and a frequency study of feline blood types in northern Italy. Vet Clin Pathol 2011; 40 (01) 32-39
    CrossrefPubMedGoogle Scholar
  • 49 Giger U, Gorman N, Hubler M. et al. Frequencies of feline A and B blood types in Europe. Anim Genet 1992; 23: 12
    PubMedGoogle Scholar
  • 50 Marques C, Ferreira M, Gomes JF. et al. Frequency of blood type A, B, and AB in 515 domestic shorthair cats from the Lisbon area. Vet Clin Pathol 2011; 40 (02) 185-187
    CrossrefPubMedGoogle Scholar
  • 51 Silvestre-Ferreira AC, Pastor J. et al. Frequencies of feline blood types in northern Portugal. Vet Clin Pathol 2004; 33 (04) 240-243
    CrossrefPubMedGoogle Scholar
  • 52 Hubler M, Arnold S, Casal M. et al. Die Blutgruppenverteilung bei den Hauskatzen in der Schweiz. Schweiz Arch Tierheilk 1993; 135: 231-235
    PubMedGoogle Scholar
  • 53 Arikan S, Gurkan M, Ozaytekin E. et al. Frequencies of blood type A, B and AB in non-pedigree domestic cats in Turkey. J Small Anim Pract 2006; 47 (01) 10-13
    CrossrefPubMedGoogle Scholar