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Aktuelle Dermatologie 2020; 46(03): 87-93
DOI: 10.1055/a-1047-2822
Originalarbeit
© Georg Thieme Verlag KG Stuttgart · New York

Einfluss oraler Kollagen-Peptide auf die Hautqualität am ganzen Körper

Impact of Oral Collagen-peptides on Skin Quality
M. Streker
Fachbereich Chemie, Institut für Biochemie und Molekularbiologie, Universität Hamburg
,
M. S. Thill
Fachbereich Chemie, Institut für Biochemie und Molekularbiologie, Universität Hamburg
,
M. Kerscher
Fachbereich Chemie, Institut für Biochemie und Molekularbiologie, Universität Hamburg
› Author Affiliations
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Publication History

Publication Date:
04 March 2020 (online)

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Zusammenfassung

Die Hautalterung ist ein komplexer Prozess, der sowohl extrinsischen als auch intrinsischen Einflüssen unterliegt. Neben sichtbaren Zeichen wie Falten und einem Verlust an Elastizität spielen sich insbesondere in der Dermis molekulare Veränderungen ab. Ein wesentlicher Faktor ist die Minderung der Qualität und Quantität von kollagenen Fasern sowie weiteren extrazellulären Matrixbestandteilen. Bereits in früheren In-vivo-Human-Studien wurde eine Verbesserung der Hautqualität im Gesicht durch die orale Supplementierung mit Kollagenpeptiden nachgewiesen. Es konnte mittels objektiver, validierter dermatologischer Messmethoden bestätigt werden, dass die orale Aufnahme von speziellen Kollagen-Peptiden über einen längeren Zeitraum die Hautphysiologie (Lipidgehalt der Hautoberfläche, Stratum-corneum-Hydratation, Hautelastizität, Hautglätte und Hautdichte) positiv beeinflusst. In der vorliegenden 12-wöchigen Studie wurden die positiven Effekte eines Nutraceuticals mit bioaktiven Kollagen-Peptiden (ELASTEN®) auf die Hautqualität erstmals am gesamten Körper (Gesicht, Dekolleté, Arm und Oberschenkel) untersucht.

Abstract

Skin aging is a complex process that is subject to both extrinsic and intrinsic influences. In addition to visible signs of aging such as wrinkles and loss of elasticity, especially in the dermis molecular changes take place. A key factor is the reduction in the quality and quantity of collagen fibres and other extracellular matrix constituents. For oral supplementation with collagen peptides, improvements in facial skin quality have already been demonstrated in in vivo human studies. It was confirmed by objective, validated dermatological measurement methods that the oral intake of special collagen peptides over a longer period positively influences the skin physiology (lipid content of the skin surface, stratum corneum hydration, skin elasticity, skin smoothness and skin density). In the present 12-week study, the positive effects of a nutraceutical with bioactive collagen peptides (ELASTEN®) on skin quality were first investigated on the entire body (face, décolleté, arm and thigh).

 

  • Literatur

  • 1 Krutmann J, Bouloc A, Sore G. et al. The skin aging exposome. J Dermatol Sci 2017; 85: 152-161
    CrossrefPubMedSearch in Google Scholar
  • 2 Lademann J, Vergou T, Darvin ME. et al. Influence of Topical, Systemic and Combined Application of Antioxidants on the Barrier Properties of the Human Skin. Skin Pharmacol Physiol 2016; 29: 41-46
    CrossrefPubMedSearch in Google Scholar
  • 3 McCook JP. Topical Products for the Aging Face. Clin Plast Surg 2016; 43: 597-604
    CrossrefPubMedSearch in Google Scholar
  • 4 Makrantonaki E, Pfeifer GP, Zouboulis CC. Intrinsic factors, genes, and skin aging. Hautarzt 2016; 67: 103-106
    CrossrefPubMedSearch in Google Scholar
  • 5 Krutmann J, Schikowski T, Huls A. et al. Environmentally induced (extrinsic) skin aging. Hautarzt 2016; 67: 99-102
    CrossrefPubMedSearch in Google Scholar
  • 6 Vierkotter A, Schikowski T, Sugiri D. et al. MMP-1 and -3 promoter variants are indicative of a common susceptibility for skin and lung aging: results from a cohort of elderly women (SALIA). J Invest Dermatol 2015; 135: 1268-1274
    CrossrefPubMedSearch in Google Scholar
  • 7 Bogdan Allemann I, Baumann L. Antioxidants used in skin care formulations. Skin Therapy Lett 2008; 13: 5-9
    PubMedSearch in Google Scholar
  • 8 Mohammed D, Crowther JM, Matts PJ. et al. Influence of niacinamide containing formulations on the molecular and biophysical properties of the stratum corneum. Int J Pharm 2013; 441: 192-201
    CrossrefPubMedSearch in Google Scholar
  • 9 Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in Skin Health. Nutrients 2017; 9
    CrossrefPubMedSearch in Google Scholar
  • 10 Birnbaum J, Le Moigne A, Dispensa L. et al. A Review of Clinical Trials Conducted With Oral, Multicomponent Dietary Supplements for Improving Photoaged Skin. J Drugs Dermatol 2015; 14: 1453-1461
    PubMedSearch in Google Scholar
  • 11 Choi FD, Sung CT, Juhasz ML. et al. Oral Collagen Supplementation: A Systematic Review of Dermatological Applications. J Drugs Dermatol 2019; 18: 9-16
    PubMedSearch in Google Scholar
  • 12 Proksch E, Schunck M, Zague V. et al. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol 2014; 27: 113-119
    CrossrefPubMedSearch in Google Scholar
  • 13 Schlippe G, Bolke L, Voss W. Einfluss oraler Einnahme von Kollagen-Peptiden auf relevante Parameter der Hautalterung: Hautfeuchtigkeit, Hautelastizität und Hautrauigkeit. Akt Dermatol 2015; 41: 529-534
    Thieme ConnectPubMedSearch in Google Scholar
  • 14 Inoue N, Sugihara F, Wang X. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study. J Sci Food Agric 2016; 96: 4077-4081
    CrossrefPubMedSearch in Google Scholar
  • 15 Calleja-Agius J, Muscat-Baron Y, Brincat MP. Skin ageing. Menopause Int 2007; 13: 60-64
    CrossrefPubMedSearch in Google Scholar
  • 16 Chung JH, Seo JY, Choi HR. et al. Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J Invest Dermatol 2001; 117: 1218-1224
    CrossrefPubMedSearch in Google Scholar
  • 17 Quan T, Little E, Quan H. et al. Elevated matrix metalloproteinases and collagen fragmentation in photodamaged human skin: impact of altered extracellular matrix microenvironment on dermal fibroblast function. J Invest Dermatol 2013; 133: 1362-1366
    PubMedSearch in Google Scholar
  • 18 Calleja-Agius J, Brincat M, Borg M. Skin connective tissue and ageing. Best Pract Res Clin Obstet Gynaecol 2013; 27: 727-740
    CrossrefPubMedSearch in Google Scholar
  • 19 Proksch E, Segger D, Degwert J. et al. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol 2014; 27: 47-55
    CrossrefPubMedSearch in Google Scholar
  • 20 Berardesca E, Maibach HI. Transepidermal water loss and skin surface hydration in the non invasive assessment of stratum corneum function. Derm Beruf Umwelt 1990; 38: 50-53
    PubMedSearch in Google Scholar
  • 21 Luebberding S, Krueger N, Kerscher M. Age-related changes in skin barrier function – quantitative evaluation of 150 female subjects. Int J Cosmet Sci 2013; 35: 183-190
    CrossrefPubMedSearch in Google Scholar
  • 22 De Luca C, Mikhalʼchik EV, Suprun MV. et al. Skin Antiageing and Systemic Redox Effects of Supplementation with Marine Collagen Peptides and Plant-Derived Antioxidants: A Single-Blind Case-Control Clinical Study. Oxid Med Cell Longev 2016; 2016: 4389410
    PubMedSearch in Google Scholar
  • 23 Genovese L, Corbo A, Sibilla S. An Insight into the Changes in Skin Texture and Properties following Dietary Intervention with a Nutricosmeceutical Containing a Blend of Collagen Bioactive Peptides and Antioxidants. Skin Pharmacol Physiol 2017; 30: 146-158
    CrossrefPubMedSearch in Google Scholar
  • 24 Yazaki M, Ito Y, Yamada M. et al. Oral Ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin. J Agric Food Chem 2017; 65: 2315-2322
    CrossrefPubMedSearch in Google Scholar
  • 25 Ohara H, Ichikawa S, Matsumoto H. et al. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. J Dermatol 2010; 37: 330-338
    CrossrefPubMedSearch in Google Scholar
  • 26 Zague V, de Freitas V, da Costa Rosa M. et al. Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity. J Med Food 2011; 14: 618-624
    CrossrefPubMedSearch in Google Scholar