Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000144.xml
Zeitschrift für Orthomolekulare Medizin 2019; 17(04): 12-16
DOI: 10.1055/a-1056-8336
DOI: 10.1055/a-1056-8336
Wissen
Vitamin D in der Prävention von Typ-2-Diabetes?!
![](https://www.thieme-connect.de/media/OM/201904/lookinside/thumbnails/10.1055a-1056-8336-1.jpg)
Zusammenfassung
Aktuelle Studien zeigen einen Zusammenhang zwischen unzureichender Versorgung mit Vitamin D und einem erhöhten Risiko für das metabolische Syndrom sowie die Progression vom Prädiabetes zum manifesten Typ-2-Diabetes. Ein Vitamin-D-Mangel erhöht die Insulinresistenz und verringert die Insulinsekretion der Betazellen im Pankreas. Von einer Supplementierung profitieren v. a. Patienten mit einem ausgeprägten Mangel.
Schlüsselwörter
Vitamin D - Diabetes mellitus Typ 2 - Prävention - metabolisches Syndrom - Betazellen - Insulinresistenz - SupplementierungPublication History
Article published online:
20 January 2020
© Georg Thieme Verlag KG
Georg Thieme Verlag KG Stuttgart · New York
-
Literatur
- 1 Gröber U, Kisters K, Schmidt J. Micronutrients in diabetology: complementary medicine update 2014. Med Monatsschr Pharm 2014; 37 (08) : 284-292
- 2 World Health Organisation (WHO). Global Report on Diabetes. 2016 https://www.who.int/diabetes/global-report/en/. Stand: 31.10.2019
- 3 Leung PS. The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus. Nutrients 2016; 8 (03) : 147
- 4 Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004; 79: 820-825
- 5 Holick MF. Nutrition: D-iabetes and D-eath D-efying vitamin D. Nat Rev Endocrinol 2012; 8 (07) : 388-390
- 6 Shen L, Zhuang QS, Ji HF. Assessment of vitamin D levels in type 1 and type 2 diabetes patients: Results from metaanalysis. Mol Nutr Food Res. 2016; 60 (05) : 1059-1067
- 7 Lemieux P, Weisnagel JS, Caron AZ. et al. Effects of 6-month vitamin D supplementation on insulin sensitivity and secretion: a randomized, placebo-controlled trial. Eur J Endocrinol. 2019 pii EJE-19-0156.R2. doi: 10.1530/EJE-19-0156 [Epub ahead of print]
- 8 Pittas AG, Dawson-Hughes B, Sheehan P. et al. Vitamin D Supplementation and Prevention of Type 2 Diabetes. N Engl J Med 2019; 381 (06) : 520-530
- 9 Pludowski P, Grant WB, Konstantynowicz J, Holick MF. Editorial: Classic and Pleiotropic Actions of Vitamin D. Front Endocrinol (Lausanne) 2019; 10: 341 . doi: 10.3389/fendo.2019.00341
- 10 Gröber U, Holick MF. Vitamin D. Die Heilkraft des Sonnenvitamins. 4.. Aufl. Stuttgart: Wissenschaftliche Verlagsgesellschaft; 2020
- 11 von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient – a randomised, placebo-controlled trial. Br J Nutr 2010; 103 (04) 549-555
- 12 Baggerly CA, Raphael E, Cuomo MPH. et al. Sunlight and Vitamin D: Necessary for Public Health. J Am Coll Nutr 2015; 34 (04) , 359-365
- 13 Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357 (03) : 266-281
- 14 Gagnon C, Lu ZX, Magliano DJ. et al. Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). J Clin Endocrinol Metab 2012; 97 (06) : 1953-1961
- 15 Deleskog A, Hilding A, Brismar K. et al. Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance. Diabetologia 2012; 55 (06) 1668-1678
- 16 Lindqvist PG, Olsson H, Landin-Olsson M. Are active sun exposure habits related to lowering risk of type 2 diabetes mellitus in women:. a prospective cohort study? Diabetes Res Clin Pract 2010; 90 (01) : 109-114
- 17 Gröber U, Holick MF. Diabetes prevention: Vitamin D supplementation does not provide any protection, if there is no evidence of deficiency. Nutrients. 2019 doi: 10.3390/nu11112651