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Zeitschrift für Orthomolekulare Medizin 2019; 17(04): 26-31
DOI: 10.1055/a-1056-9982
Wissen

Ist die Sarkoidose eine durch Vitamin D getriggerte Krebsabwehr?

EPOCA-Hypothese: Endogenes Programm organisiert Apoptose der Krebszellen
Raimund von Helden∗
,
William B. Grant
,
Meis Moukayed
,
Bernd Becker
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Zusammenfassung

Die Ursache der Sarkoidose ist bislang unbekannt. Vitamin D ist zur Behandlung der Erkrankung kontraindiziert. Wir fragen daher, was Sarkoidose verursacht und warum Vitamin D für die Betroffenen gefährlich sein kann und schlagen eine gegenteilige Hypothese vor: Sarkoidose ist ein physiologischer Prozess der Krebsabwehr, der Vitamin D als Substrat benötigt. Zur Prüfung der Hypothese haben wir anhand einer Literaturrecherche zahlreiche Fallberichte über Sarkoidose und Krebs gefunden sowie Fälle von Krebsmimikry durch Sarkoidose. Mehrere Berichte beschreiben Spontanheilungen der Krebserkrankung bei gleichzeitigem Auftreten einer Sarkoidose. Im Zusammenhang mit den Granulomen der Sarkoidose bilden Monozyten den Ort der Vitamin-D-Freisetzung. Darüber hinaus kann aktives Vitamin D Krebszellen mithilfe der Vitamin-D-Rezeptoren des Zellkerns kontrollieren. Dass Granulome „nicht verkäsend“ sind, wird als Resorption von humanen Molekülen der Krebszellen erklärt. Der Umstand, dass in den Granulomen der Sarkoidose meist Krebszellen fehlen, wird als Ergebnis einer gut funktionierenden Sarkoidose interpretiert. Wir betrachten die typische Synthese von aktivem Vitamin D in den Sarkoidose-Monozyten als Krebsabwehr. Die Hypothese muss durch weitere Untersuchungen untermauert werden.

Keywords

Sarkoidose - Krebs - Monozyten - Neoplasie - Vitamin D - Hyperkalzämie - Spontanremission - 25-Cholecalciferol - 1,25-Cholecalciferol, Ätiologie, Apoptose


Publication History

Article published online:
20 January 2020

© Georg Thieme Verlag KG
Georg Thieme Verlag KG Stuttgart · New York

 

  • Literatur

  • Die Literaturliste finden Sie online unter: https://doi.org/10.1055/a-1056-9982.
  • 1 Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. NEJM 2007; 357: 2153-2165
    PubMed
  • 2 Nunes H, Bouvry D, Soler P. et al. Sarcoidosis.. Orphanet journal of rare diseases 2007; 2: 46
    CrossrefPubMedGoogle Scholar
  • 3 Rybicki BA, Major M, Jr Popovich J Jr. et al. Racial differences in sarcoidosis incidence: A 5-year study in a health maintenance organization.. Am J Epidemiol 1997; 145: 234-241
    CrossrefPubMedGoogle Scholar
  • 4 Grand S, Hoffmann D, Bost F. et al. Case report: Pseudotumoral brain lesion as the presenting feature of sarcoidosis. Br J Radiol 1996; 69: 272-275
    CrossrefPubMedGoogle Scholar
  • 5 McCartney WH, Lindner LE, Prather JL. et al. Brain scan abnormalities in intracerebral sarcoidosis. Clin Nuclear Med 1979; 4: 32-34
    CrossrefPubMedGoogle Scholar
  • 6 Badelon I, Chaine G. [eye manifestations of sarcoidosis].. La Revue du praticien 1994; 44: 2042-2045
    PubMedGoogle Scholar
  • 7 Cross AG. Sarcoidosis of the eye.. Br J Ophthalm 1953; 37: 247-250
    Google Scholar
  • 8 Cozier YC, Berman JS, Palmer JR. et al. Sarcoidosis in black women in the united states: Data from the black women's health study. Chest 2011; 139: 144-150
    CrossrefPubMedGoogle Scholar
  • 9 Heath CR, David J, Taylor SC. Sarcoidosis: Are there differences in your skin of color patients?. J Am Acad Dermatol 2012; 66 (121) e121-114
    Google Scholar
  • 10 Keller AZ. Hospital, age, racial, occupational, geographical, clinical and survivorship characteristics in the epidemiology of sarcoidosis.. Am J Epidemiol 1971; 94: 222-230
    CrossrefPubMedGoogle Scholar
  • 11 Mirsaeidi M, Machado RF, Schraufnagel D. et al. Racial difference in sarcoidosis mortality in the united states. Chest 2015; 147: 438-449
    CrossrefPubMedGoogle Scholar
  • 12 Judson MA, Boan AD, Lackland DT. The clinical course of sarcoidosis: Presentation, diagnosis, and treatment in a large white and black cohort in the united states. Sarcoidosis Vasc Diffuse Lung Dis 2012; 29: 119-127
    PubMedGoogle Scholar
  • 13 Swigris JJ, Olson AL, Huie TJ. et al. Sarcoidosis-related mortality in the united states from 1988 to 2007. Am J Respir Crit Care Med 2011; 183: 1524-1530
    CrossrefPubMedGoogle Scholar
  • 14 Hillerdal G, Nou E, Osterman K. et al. Sarcoidosis: Epidemiology and prognosis. A 15-year european study. Am Rev Respiratory Dis 1984; 130: 29-32
    PubMedGoogle Scholar
  • 15 Milman N, Selroos O. Pulmonary sarcoidosis in the nordic countries 1950–1982. Ii. Course and prognosis. Sarcoidosis 1990; 7: 113-118
    PubMedGoogle Scholar
  • 16 Siltzbach LE, James DG, Neville E. et al. Course and prognosis of sarcoidosis around the world. Am J Med 1974; 57: 847-852
    CrossrefPubMedGoogle Scholar
  • 17 Statement on sarcoidosis. Joint statement of the american thoracic society (ats), the european respiratory society (ers) and the world association of sarcoidosis and other granulomatous disorders (wasog) adopted by the ats board of directors and by the ers executive committee, february 1999. Am J Respir Crit Care Med 1999; 160: 736-755
    CrossrefPubMed
  • 18 Von Helden R. Numerous cases of sarcoidosis masquerading neoplasia: By chance or by etiological association?. Anticancer Res 2011; 31: 1489-1512
    Google Scholar
  • 19 De Vries J, Lower EE, Drent M. Quality of life in sarcoidosis: Assessment and management. Semin Respir Crit Care Med 2010; 31: 485-493
    Article in Thieme ConnectPubMedGoogle Scholar
  • 20 Adams JS, Sharma OP, Gacad MA. et al. Metabolism of 25-hydroxyvitamin d3 by cultured pulmonary alveolar macrophages in sarcoidosis. J Clin Investigation 1983; 72: 1856-1860
    CrossrefPubMedGoogle Scholar
  • 21 Hanibuchi M, Matsumori Y, Nishioka Y. et al. A case of sarcoidosis accompanying squamous cell carcinoma in the mandibular gingiva. JMI 2005; 52: 118-121
    PubMedGoogle Scholar
  • 22 Lieberman J. Elevation of serum angiotensin-converting-enzyme (ace) level in sarcoidosis. Am J Med 1975; 59: 365-372
    CrossrefPubMedGoogle Scholar
  • 23 Dupont M, Jover B, Mialanes N. et al. [clinical value of the estimation of plasma converting enzyme activity]. Pathologie-biologie 1984; 32: 698-701
    PubMedGoogle Scholar
  • 24 Yukawa M, Satoh T, Takayama K. et al. Cutaneous sarcoid reaction in a patient with bladder cancer. Eur J Dermatol 2010; 20: 235
    PubMedGoogle Scholar
  • 25 Suvajdzic N, Milenkovic B, Perunicic M. et al. Two cases of sarcoidosislymphoma syndrome. Medical Oncology 2007; 24: 469-471
    CrossrefPubMedGoogle Scholar
  • 26 Falchero L, Nesme P, Perol M. et al. [spontaneous resolution of multiorgan sarcoidosis associated with malignant lymphoma]. Revue des maladies respiratoires 1998; 15: 287-289
    PubMedGoogle Scholar
  • 27 Tjan-Heijnen VC, Vlasveld LT, Pernet FP. et al. Coincidence of seminoma and sarcoidosis: A myth or fact? Ann Oncol 1998; 9: 321-325
    CrossrefPubMed
  • 28 Morand JJ, Paris JF, Gisserot O. et al. [pseudo-sarcoidotic lymphoma and nephrotic syndrome in a hepatitis c-carrying female patient]. La Presse medicale 1998; 27: 668
    PubMedGoogle Scholar
  • 29 Sorrells T, Pratt L, Newton J. et al. Spontaneous regression of granulomatous mycosis fungoides in an hiv positive patient. J Am Acad Dermatol 1997; 37: 876-880
    CrossrefPubMedGoogle Scholar
  • 30 Jager J, Andriessen MP, van Ingen J. Bone lesions mimicking disseminated malignancy after remission of thoracic sarcoidosis. The Netherlands journal of medicine 1990; 36: 204-206
    PubMedGoogle Scholar
  • 31 Prevost JN, Marin I, Othman H. et al. [recurrence of sarcoidosis stage i after recovery]. La Presse medicale 1986; 15: 761
    PubMedGoogle Scholar
  • 32 de la Figuera M, Biosca M, Garcia-Bragado F. et al. Spontaneous regression of bilateral hilar lymphadenopathy in renal cell carcinoma. Eur J Respiratory Dis 1985; 67: 133-135
    Google Scholar
  • 33 Goljan-Geremek A, Puscinska E, Bednarek M. et al. Fatal clinical outcome in a patient with sarcoidosislymphoma syndrome. Pneumonologia i alergologia polska 2013; 81: 542-549
    PubMedGoogle Scholar
  • 34 Hunt DP, Muse VV, Ly A. Case records of the massachusetts general hospital. Case 4-2014. A 39-year-old man with night sweats and abdominal pain. NEJM 2014; 370: 467-473
    PubMedGoogle Scholar
  • 35 Macri A, Constantin A, Cordos I. et al. [coexistence of mediastinal adenopathies of different etiologies – case report]. Pneumologia (Bucharest, Romania) 2013; 62: 114-121
    PubMedGoogle Scholar
  • 36 Tanizawa K, Tanaka E, Hashimoto S. et al. Paradoxical development of a sarcoid-like reaction during successful chemotherapy for seminoma. Int Med 2010; 49: 1423-1426
    CrossrefPubMedGoogle Scholar
  • 37 Grutters JC. van den Bosch JM. Corticosteroid treatment in sarcoidosis. Eur Respir J 2006; 28: 627-636
    CrossrefPubMedGoogle Scholar
  • 38 Von Helden R. Healthy in seven days - success through vitamin d treatment. Dresden: Hygeia Publishing; 2014
    Google Scholar
  • 39 Kirsten D, Magnusson H. Sarcoidose up-date 2000 Interpneu: 2000
    PubMed
  • 40 Muller-Quernheim J. Sarcoidosis:. Immunopathogenetic concepts and their clinical application. Eur Respir J 1998; 12: 716-738
    CrossrefPubMedGoogle Scholar
  • 41 Rose CS, Martyny JW, Newman LS. et al. "Lifeguard lung": Endemic granulomatous pneumonitis in an indoor swimming pool. Am J Public Health 1998; 88: 1795-1800
    CrossrefPubMedGoogle Scholar
  • 42 Saidha S, Sotirchos ES, Eckstein C. Etiology of sarcoidosis: Does infection play a role? Yale Journal of Biology and Medicine 2012; 85: 133-141
    PubMed
  • 43 Rafnsson V, Ingimarsson O, Hjalmarsson I. et al. Association between exposure to crystalline silica and risk of sarcoidosis. Occupational and Environmental Medicine 1998; 55: 657-660
    CrossrefPubMedGoogle Scholar
  • 44 De Vuyst P, Dumortier P, Moulin E. et al. Diagnostic value of asbestos bodies in bronchoalveolar lavage fluid. Am Rev Respiratory Dis 1987; 136: 1219-1224
    PubMedGoogle Scholar
  • 45 Newman LS. Metals that cause sarcoidosis. Seminars in Respiratory Infections 1998 13. 212-220
    PubMed
  • 46 Redline S, Barna BP, Tomashefski JF. et al. Granulomatous disease associated with pulmonary deposition of titanium. Br J Industrial Med 1986; 43: 652-656
    Google Scholar
  • 47 Skelton HG. 3rd, Smith KJ, Johnson FB et al. Zirconium granuloma resulting from an aluminum zirconium complex: A previously unrecognized agent in the development of hypersensitivity granulomas. J Am Acad Dermatol 1993; 28: 874-876
    PubMed
  • 48 Newman LS, Rose CS, Bresnitz EA. et al. A case control etiologic study of sarcoidosis: Environmental and occupational risk factors. Am J Respir Crit Care Med 2004; 170: 1324-1330
    CrossrefPubMedGoogle Scholar
  • 49 Safianowska A, Grubek-Jaworska H, Droszcz P. et al. [levels of cea, antibodies against mycobacterial antigens and ace activity in serum and in balf in patients with sarcoidosis, tuberculosis and lung cancer--preliminary results]. Pneumonologia i alergologia polska 2001; 69: 5-13
    PubMedGoogle Scholar
  • 50 Dabrowska M, Grubek-Jaworska H, Domagala-Kulawik J. et al. [diagnostic usefulness of selected tumor markers (ca125, cea, cyfra 21-1) in bronchoalveolar lavage fluid in patients with non-small cell lung cancer]. Polskie Archiwum Medycyny Wewnetrznej 2004; 111: 659-665
    PubMedGoogle Scholar
  • 51 Alexandrescu DT, Kauffman CL, Ichim TE. et al. Cutaneous sarcoidosis and malignancy: An association between sarcoidosis with skin manifestations and systemic neoplasia. Dermatology Online Journal 2011; 17: 2
    PubMedGoogle Scholar
  • 52 Brincker H. Sarcoidosis and malignancy. Chest 1995; 108: 1472-1474
    CrossrefPubMedGoogle Scholar
  • 53 Caras WE, Dillard T, Baker T. et al. Coexistence of sarcoidosis and malignancy. Southern Medical Journal 2003; 96: 918-922
    CrossrefPubMedGoogle Scholar
  • 54 Cohen PR, Kurzrock R. Sarcoidosis and malignancy. Clin Dermatol 2007; 25: 326-333
    CrossrefPubMedGoogle Scholar
  • 55 Bonifazi M, Bravi F, Gasparini S. et al. Sarcoidosis and cancer risk: Systematic review and meta-analysis of observational studies. Chest 2015; 147: 778-791
    CrossrefPubMedGoogle Scholar
  • 56 Seersholm N, Vestbo J, Viskum K. Risk of malignant neoplasms in patients with pulmonary sarcoidosis. Thorax 1997; 52: 892-894
    CrossrefPubMedGoogle Scholar
  • 57 Ungprasert P, Srivali N, Wijarnpreecha K. et al. Is the incidence of malignancy increased in patients with sarcoidosis? A systematic review and meta-analysis. Respirology 2014; 19: 993-998
    CrossrefPubMedGoogle Scholar
  • 58 Yukawa Y, Kato F. Isolated spinal cord sarcoidosis mimicking an intramedullary tumor. J Spin Disord 1999; 12: 530-533
    Google Scholar
  • 59 Woolf R, Toms L, Mann B. Systemic sarcoidosis mimicking advanced testicular cancer. J R Soc Med 2010; 103: 251-253
    CrossrefPubMedGoogle Scholar
  • 60 Wilson JD, Castillo M, Van Tassel P. Mri features of intracranial sarcoidosis mimickingmeningiomas. Clinical imaging 1994; 18: 184-188
    CrossrefPubMedGoogle Scholar
  • 61 Weiss IA, Limaye A, Tchertkoff V. et al. Sarcoidosis of the thyroid clinically mimicking malignancy. New York State Journal of Medicine 1989; 89: 578-580
    PubMedGoogle Scholar
  • 62 Weil RJ. Meningeal neurosarcoidosis mimicking convexity meningioma. Case illustration. J Neurosurgery 2001; 94: 1013
    Google Scholar
  • 63 Vaz FM, Samuel D. Postcricoid sarcoid mimicking a malignancy: A lesson to remember. Otolaryngology – Head and Neck Surgery 2000; 123: 150
    CrossrefPubMedGoogle Scholar
  • 64 Valencia MP, Deaver PM, Mammarappallil MC. Sarcoidosis of the thoracic and lumbar vertebrae, mimicking metastasis or multifocal osteomyelitis by mri: Case report. Clinical Imaging 2009; 33: 478-481
    CrossrefPubMedGoogle Scholar
  • 65 Uruha A, Koide R, Taniguchi M. Unusual presentation of sarcoidosis: Solitary intracranial mass lesion mimicking a glioma. J Neuroimaging 2011; 21: e180-182
    CrossrefPubMedGoogle Scholar
  • 66 Umezu H, Chida M, Inoue T. et al. Sarcoidosis development during induction chemotherapy for lung cancer mimicked progressive disease. General Thoracic and Cardiovascular Surgery 2010; 58: 434-437
    CrossrefPubMedGoogle Scholar
  • 67 Tsao CY, Lo WD, Rusin JA. et al. Isolated neurosarcoidosis presenting as headache and multiple brain and spinal cord lesions mimicking central nervous system metastases. Brain & Development 2007; 29: 514-518
    CrossrefPubMedGoogle Scholar
  • 68 Tolaney SM, Colson YL, Gill RR. et al. Sarcoidosis mimicking metastatic breast cancer. Clinical Breast Cancer 2007; 7: 804-810
    CrossrefPubMedGoogle Scholar
  • 69 Talmi D, Smith S, Mulligan ME. Central skeletal sarcoidosis mimicking metastatic disease. Skeletal Radiology 2008; 37: 757-761
    CrossrefPubMedGoogle Scholar
  • 70 Talamonti G, Ligarotti GK, Bramerio M. et al. Unusual behaviour of a pineal germinoma mimicking neurosarcoidosis and metastasising along the endoscopic route. BMJ Case Reports. 2013: 2013
    Google Scholar
  • 71 Takanami K, Kaneta T, Yamada T. et al. Fdg pet for esophageal cancer complicated by sarcoidosis mimicking mediastinal and hilar lymph node metastases: Two case reports. Clinical Nuclear Medicine 2008; 33: 258-261
    CrossrefPubMedGoogle Scholar
  • 72 Suzuki K, Morise Z, Furuta S. et al. Hepatic sarcoidosis mimicking hilar cholangiocarcinoma: Case report and review of the literature. Case Reports in Gastroenterology. 2011 5. 152-158
    PubMedGoogle Scholar
  • 73 SultanAli I, Zaman M, Yende S. Sarcoidosis mimicking disseminated testicular cancer. Southern Medical Journal 2005; 98: 935-936
    PubMedGoogle Scholar
  • 74 Su CT, Chen LK, Tsai YF. et al. Disseminated cryptococcosis with pulmonary and marrow involvement mimicking radiological features of malignancy. JCMA 2004; 67: 89-92
    PubMedGoogle Scholar
  • 75 Strickland-Marmol LB, Fessler RG, Rojiani AM. Necrotizing sarcoid granulomatosis mimicking an intracranial neoplasm: Clinicopathologic features and review of the literature. Modern Pathology 2000; 13: 909-913
    CrossrefPubMedGoogle Scholar
  • 76 Stokkel MP, van der Hiel B, Olmos RV. et al. Fluorodeoxyglucose pet / ct in subcutaneous sarcoidosis mimicking cutaneous lymphoma. Eur J Nuclear Med Molecular Imaging 2012; 39: 919-920
    Google Scholar
  • 77 Soyer P, Gottlieb L, Bluemke DA. et al. Sarcoidosis of the pancreas mimicking pancreatic cancer: Ct features. Eur J Radiol 1994; 19: 32-33
    CrossrefPubMedGoogle Scholar
  • 78 Sickles EA, Sklansky BD, Wiernik PH. Benign intrathoracic lesions mimicking recurrent cancer. JAMA 1973; 225: 156-158
    CrossrefPubMedGoogle Scholar
  • 79 Shiraishi Y, Kimura A, Seichi A. et al. Multifocal extramedullary spinal sarcoid lesions mimicking leptomeningeal metastasis. J Orthop Sci 2013; 18: 343-346
    CrossrefPubMedGoogle Scholar
  • 80 Sahin H, Ceylan N, Bayraktaroglu S. et al. Necrotizing sarcoid granulomatosis mimicking lung malignancy: Mdct, pet-ct and pathologic findings. Iranian Journal of Radiology 2012; 9: 37-41
    CrossrefPubMedGoogle Scholar
  • 81 Sagalow BR, Miller CL, Wechsler RJ. Pancreatic sarcoidosis mimicking pancreatic cancer. JCU 1988; 16: 131-134
    PubMedGoogle Scholar
  • 82 Rodriguez F, Link MJ, Driscoll CL. et al. Neurosarcoidosis mimicking meningioma. Arch Neurol 2005; 62: 148-149
    CrossrefPubMedGoogle Scholar
  • 83 Rice CM, Beric V, Love S. et al. Neurological picture.. Vertebral sarcoidosis mimicking metastases. J Neurol Neurosurg Psychiatry 2011; 82: 188
    PubMedGoogle Scholar
  • 84 Rawlings DJ, Bernstein B, Rowland JM. et al. Prolonged course of illness in a child with malignant lymphoma mimicking sarcoidosis. J Rheumatol 1993; 20: 1583-1587
    Google Scholar
  • 85 Ramanathan RS, Malhotra K, Scott T. Teaching neuroimages: Diffuse cerebral neurosarcoidosis mimicking gliomatosis cerebri. Neurology 2013; 81: e46
    CrossrefPubMedGoogle Scholar
  • 86 Quinones-Hinojosa A, Chang EF, Khan SA. et al. Isolated trigeminal nerve sarcoid granuloma mimicking trigeminal schwannoma: Case report. Neurosurgery 2003; 52: 700-705
    CrossrefPubMedGoogle Scholar
  • 87 Pungpapong S, Steers JL, Wallace MB. et al. Hepatobiliary sarcoidosis mimicking klatskin's cholangiocarcinoma. Gastrointestinal Endoscopy 2006; 64: 124-125
    CrossrefPubMedGoogle Scholar
  • 88 Powers WJ, Miller EM. Sarcoidosis mimicking glioma: Case report and review of intracranial sarcoid mass lesions. Neurology. 1981 31. 907-910
    PubMedGoogle Scholar
  • 89 Powell JL, Cunill ES, Gajewski WH. et al. Sarcoidosis mimicking recurrent endometrial cancer. Gynecologic Oncology 2005; 99: 770-773
    CrossrefPubMedGoogle Scholar
  • 90 Pollock JM, Greiner FG, Crowder JB. et al. Neurosarcoidosis mimicking a malignant optic glioma. J Neuro-Ophthalmology 2008; 28: 214-216
    Google Scholar
  • 91 Piattelli A, Favia GF, Di Alberti L. Oral ulceration as a presenting sign of unknown sarcoidosis mimicking a tumour: Report of 2 cases. Oral Oncology. 1998 34. 427-430
    PubMedGoogle Scholar
  • 92 Paydas S, Disel U, Yavuz S. et al. Granulomatous orchitis mimicking hodgkin's lymphoma relapse. Hematology Journal 2003; 4: 370-371
    CrossrefPubMedGoogle Scholar
  • 93 Packer CD, Mileti LM. Vertebral sarcoidosis mimicking lytic osseous metastases: Development 16 years after apparent resolution of thoracic sarcoidosis. J Clin Rheumatol 2005; 11: 105-108
    CrossrefPubMedGoogle Scholar
  • 94 Osenbach RK, Blumenkopf B, Ramirez H Jr, Et al. Meningeal neurosarcoidosis mimicking convexity en-plaque meningioma. Surgical Neurology 1986; 26: 387-390
    CrossrefPubMedGoogle Scholar
  • 95 Oketani M, Tsubouchi H, Hori T. et al. Sarcoidosis with tumorous hepatic and bone lesions mimicking disseminated malignancy: A case report. Gastroenterologia Japonica 1992; 27: 414-417
    CrossrefPubMedGoogle Scholar
  • 96 Ohana G, Melki Y, Rosenblat Y. et al. Pancreatic sarcoidosis mimicking a malignant tumour. Eur J Surgery 2002; 168: 513-515
    Google Scholar
  • 97 Nowak DA, Gumprecht H, Widenka DC. et al. Solitary sarcoid granulomatosis mimicking meningioma. J Neurosurgery 2000; 93: 897
    Google Scholar
  • 98 North J, Mully T. Alpha-interferon induced sarcoidosis mimicking metastatic melanoma. J Cutaneous Pathology 2011; 38: 585-589
    PubMedGoogle Scholar
  • 99 Nehls O, Hass HG, Weber P. et al. Sarcoidosis mimicking cholangiocarcinoma. Endoscopy 2006; 38 (Suppl. 2): E65-66
    Article in Thieme ConnectPubMedGoogle Scholar
  • 100 Naraynsingh V, Hariharan S, Dan D. et al. Conservative management for idiopathic granulomatous mastitis mimicking carcinoma: Case reports and literature review. Breast Disease 2010; 31: 57-60
    CrossrefPubMedGoogle Scholar
  • 101 Mosnier E, Siles P, Ebbo M. et al. Clinical images: Bone sarcoidosis mimicking multiple metastases. Arthritis and Rheumatism 2011; 63: 1542
    CrossrefPubMedGoogle Scholar
  • 102 Mingins C, Williams MR, Cox NH. Subcutaneous sarcoidosis mimicking breast carcinoma. Br J Dermatol 2002; 146: 924-925
    CrossrefPubMedGoogle Scholar
  • 103 Mayne AI, Ahmad J, Loughrey M. et al. Sarcoidosis of the pancreas mimicking adenocarcinoma. BMJ Case Reports. 2013: 2013
    Google Scholar
  • 104 Mapelli P, Mangili G, Picchio M. et al. Sarcoidosis mimicking metastatic gynaecological malignancies: A diagnostic and therapeutic challenge?. Revista espanola de medicina nuclear e imagen molecular 2013; 32: 314-317
    PubMedGoogle Scholar
  • 105 Majori M, Anghinolfi M, Scarascia A. et al. Pulmonary sarcoidosis mimicking multiple pulmonary metastases. Monaldi Archives for Chest Disease 2012; 77: 38-39
    PubMedGoogle Scholar
  • 106 MacGregor G. Giant-cell arteritis mimicking carcinoma of the breast. BMJ 1981; 283: 236
    PubMedGoogle Scholar
  • 107 Ludwig V, Fordice S, Lamar R. et al. Unsuspected skeletal sarcoidosis mimicking metastatic disease on fdg positron emission tomography and bone scintigraphy. Clinical Nuclear Medicine 2003; 28: 176-179
    PubMedGoogle Scholar
  • 108 Looijen R, Hoekstra HJ, Sleijfer DT. et al. Sarcoid reaction mimicking intrathoracic dissemination of testicular cancer. Cancer 1990; 66: 2221-2223
    CrossrefPubMedGoogle Scholar
  • 109 Lipper MH, Goldstein JM. Neurosarcoidosis mimicking a cerebellopontine angle meningioma. AJR. Am J Roentgenol 1998; 171: 275-276
    CrossrefPubMedGoogle Scholar
  • 110 Li W, Holdeman K, Laurini JA. et al. Sarcoidosis mimicking recurrent lymphoma. Am J Hematol 2012; 87: 711-712
    CrossrefPubMedGoogle Scholar
  • 111 Lee M, Epstein FJ, Rezai AR. et al. Nonneoplastic intramedullary spinal cord lesions mimicking tumors. Neurosurgery 1998; 43: 788-794
    CrossrefPubMedGoogle Scholar
  • 112 Kolilekas L, Triantafillidou C, Manali E. et al. The many faces of sarcoidosis: A symptomatic muscle mass mimicking giant-cell tumor. Rheumatol Int 2009; 29: 1389-1390
    CrossrefPubMedGoogle Scholar
  • 113 Kok TC, Haasjes JG, Splinter TA. et al. Sarcoid-like lymphadenopathy mimicking metastatic testicular cancer. Cancer 1991; 68: 1845-1847
    CrossrefPubMedGoogle Scholar
  • 114 Kim YB, Chung YG, Kim SJ. et al. Extensive systemic sarcoidosis with testicular involvement mimicking metastatic testicular cancer. Korean J Urology 2011; 52: 295-297
    Google Scholar
  • 115 Kim MH, Lee K, Kim KU. et al. Sarcoidosis mimicking cancer metastasis following chemotherapy for ovarian cancer. Cancer Res Treat 2013; 45: 354-358
    CrossrefPubMedGoogle Scholar
  • 116 Khiar A, Duet M, Ammari S. et al. Disseminated bone involvement in systemic sarcoidosis mimicking bone metastases. A multimodality imaging approach. Joint Bone Spine 2011; 78: 216-217
    PubMedGoogle Scholar
  • 117 Kay JM. Correspondence re: Strictland-marmol lb, fessler rg, rojiani am. Necrotizing sarcoid granulomatosis mimicking an intracranial neoplasm: Clinicopathologic features and review of the literature. Mod Pathol 2000; 13: 909–903. Modern Pathology 2001; 14: 533
    PubMed
  • 118 Karmaniolas K, Liatis S, Dalamaga M. et al. A case of ovarian sarcoidosis mimicking malignancy. Eur J Gynaecol Oncol 2005; 26: 231-232
    PubMedGoogle Scholar
  • 119 Jung G, Brill N, Poll LW. et al. Mri of hepatic sarcoidosis: Large confluent lesions mimicking malignancy. AJR 2004; 183: 171-173
    Google Scholar
  • 120 Johnson MD, Powell SZ, Boyer PJ. et al. Dural lesions mimicking meningiomas. Human Pathology 2002; 33: 1211-1226
    CrossrefPubMedGoogle Scholar
  • 121 Jackson RJ, Goodman JC, Huston DP. et al. Parafalcine and bilateral convexity neurosarcoidosis mimicking meningioma: Case report and review of the literature. Neurosurgery. 1998 42. 635-638
    PubMedGoogle Scholar
  • 122 Hollister D Jr., Lee MS, Eisen RN. et al. Variable problems in lymphomas: Case 2. Sarcoidosis mimicking progressive lymphoma. J Clin Oncol 2005; 23: 8113-8116
    PubMedGoogle Scholar
  • 123 Herrero Fernandez B, Fernandez Perez E, Rodriguez Fuertes SJ. et al. [neurosarcoidosis mimicking cerebral tumor]. Anales de medicina interna 1997; 14: 139-141
    PubMedGoogle Scholar
  • 124 Henrichs MP, Streitburger A, Gosheger G. et al. Scar sarcoidosis on a finger mimicking a rapidly growing soft tissue tumour: A case report. BMC Research Notes 2012; 5: 545
    CrossrefPubMedGoogle Scholar
  • 125 Gusakova I, Lavrenkov K, Ariad S. et al. Pulmonary sarcoidosis mimicking metastases in breast cancer patients. Onkologie 2007; 30: 327-328
    PubMedGoogle Scholar
  • 126 Grubstein A, Cohen M, Steinmetz A. et al. Siliconomas mimicking cancer. Clinical Imaging 2011; 35: 228-231
    CrossrefPubMedGoogle Scholar
  • 127 Gallimore AP, George CD, Lampert IA. Subcutaneous sarcoidosis mimicking carcinoma of the breast Postgraduate Medical Journal 1990; 66: 677-678
    CrossrefPubMed
  • 128 Fujimoto H, Ikeda M, Shimofusa R. et al. Sarcoidosis breaching the fascia and mimicking a sarcoma. Skeletal Radiology 2002; 31: 706-708
    CrossrefPubMedGoogle Scholar
  • 129 Fuchs F, Le Tohic A, Raynal P. et al. [ovarian and peritoneal sarcoidosis mimicking an ovarian cancer]. Gynecologie, Obstetrique & Fertilite 2007; 35: 41-44
    Google Scholar
  • 130 Fong ZV, Wong J, Maley WR. et al. Sarcoid-reaction mimicking metastatic malignant hepatopancreatobiliary tumors: Report of two cases and review of the literature. Journal of Gastrointestinal Surgery. 2012 16. 1245-1250
    PubMedGoogle Scholar
  • 131 Fitch PS, Smith ME, Davies MG. et al. A case of lymphomatoid granulomatosis mimicking sarcoidosis. Respiratory medicine 1998; 92: 966-968
    CrossrefPubMedGoogle Scholar
  • 132 Fazzi P, Solfanelli S, Morelli G. et al. Sarcoidosis: Single bulky mesenteric lymph node mimicking a lymphoma. Sarcoidosis 1995; 12: 75-77
    PubMedGoogle Scholar
  • 133 Esnakula AK, Coleman P, Ahaghotu CA. et al. Scrotal mass and unilateral lung masses with pleural effusion mimicking metastatic testicular malignancy: An unusual presentation of sarcoidosis. BMJ Case Reports 2013
  • 134 Curti A, Rampini C, Gallazzi M. et al. [isolated muscular sarcoidosis mimicking a tumoral lesion]. Reumatismo 2004; 56: 57-60
    PubMedGoogle Scholar
  • 135 Connellan SJ, Perceval PE, Wilson RS. Sarcoidosis mimicking malignancy. Br J Dis Chest 1978; 72: 343-344
    CrossrefPubMedGoogle Scholar
  • 136 Bush E, Lamonica D, O'Connor T. Sarcoidosis mimicking metastatic breast cancer. Breast Journal 2011; 17: 533-535
    CrossrefPubMedGoogle Scholar
  • 137 Bose B. Extramedullary sarcoid lesion mimicking intraspinal tumor. Spine J 2002; 2: 381-385
    CrossrefPubMedGoogle Scholar
  • 138 Bodo M, Dobrossy L, Sugar J. Boeck's sarcoidosis of the breast: Cytologic findings with aspiration biopsy cytology. A case clinically mimicking carcinoma. Acta Cytologica 1978; 22: 1-2
    PubMedGoogle Scholar
  • 139 Bodie BF, Kheir SM, Omura EF. Calvarial sarcoid mimicking metastatic disease. J Am Acad Dermatol 1980; 3: 401-405
    CrossrefPubMedGoogle Scholar
  • 140 Beros V, Houra K, Rotim K. et al. Thoracic intramedullary sarcoidosis mimicking an intramedullary tumor. Collegium antropologicum 2008; 32: 645-647
    PubMedGoogle Scholar
  • 141 Bauones S, Le Corroller T, Durieux O. et al. Splenic sarcoidosis mimicking neoplastic disease. JCU 2014; 42: 38-41
    PubMedGoogle Scholar
  • 142 Barazi S, Bodi I, Thomas N. Sarcoidosis presenting as an isolated extradural thoracolumbar lesion mimicking tumour. Br J Neurosurgery 2008; 22: 690-691
    CrossrefPubMedGoogle Scholar
  • 143 Arana Yi C. McCue P, Rosen M. et al. Sarcoidosis mimicking metastatic bone disease in head and neck cancer. Seminars in Oncology 2013 40. 529-534
    PubMed
  • 144 Akdogan M, Ulas M, Kayhan B. et al. Gastrointestinal sarcoidosis mimicking colonic cancer. Turkish J Gastroenterol 2008; 19: 136-138
    Google Scholar
  • 145 Abrey LE, Rosenblum MK, DeAngelis LM. Sarcoidosis of the cauda equina mimicking leptomeningeal malignancy. J Neuro-Oncology 1998; 39: 261-265
    CrossrefPubMedGoogle Scholar
  • 146 Bansal AS, Bruce J, Hogan PG. et al. An assessment of peripheral immunity in patients with sarcoidosis using measurements of serum vitamin d3, cytokines and soluble cd23. Clin Exp Immunol 1997; 110: 92-97
    CrossrefPubMedGoogle Scholar
  • 147 Garland CF, Gorham ED, Mohr SB. et al. Vitamin d and prevention of breast cancer: Pooled analysis. J Steroid Biochem Mol Biol 2007; 103: 708-711
    CrossrefPubMedGoogle Scholar
  • 148 Gorham ED, Garland CF, Garland FC. et al. Vitamin d and prevention of colorectal cancer. J Steroid Biochem Mol Biol 2005; 97: 179-194
    CrossrefPubMedGoogle Scholar
  • 149 Adams JS, Singer FR, Gacad MA. et al. Isolation and structural identification of 1,25-dihydroxyvitamin d3 produced by cultured alveolar macrophages in sarcoidosis. J Clin Endocrinol Metab 1985; 60: 960-966
    CrossrefPubMedGoogle Scholar
  • 150 Adams JS, Gacad MA, Singer FR. et al. Production of 1,25-dihydroxyvitamin d3 by pulmonary alveolar macrophages from patients with sarcoidosis. Ann N Y Acad Sci 1986; 465: 587-594
    CrossrefPubMedGoogle Scholar
  • 151 Monkawa T, Yoshida T, Hayashi M. et al. Identification of 25-hydroxyvitamin d3 1alpha-hydroxylase gene expression in macrophages. Kidney Int 2000; 58: 559-568
    CrossrefPubMedGoogle Scholar
  • 152 Berlin JL, Shantha GP, Yeager H. et al. Serum vitamin d levels may not reflect tissue-level vitamin d in sarcoidosis. BMJ Case Reports. 2014
    PubMedGoogle Scholar
  • 153 Overbergh L, Stoffels K, Waer M. et al. Immune regulation of 25-hydroxyvitamin d-1alpha-hydroxylase in human monocytic thp1 cells: Mechanisms of interferon-gamma-mediated induction. J Clin Endocrinol Metab 2006; 91: 3566-3574
    CrossrefPubMedGoogle Scholar
  • 154 Fleet JC. Molecular actions of vitamin d contributing to cancer prevention. Mol Aspects Med 2008; 29: 388-396
    CrossrefPubMed
  • 155 Gregory KJ, Zhao B, Bielenberg DR. et al. Vitamin d binding protein-macrophage activating factor directly inhibits proliferation, migration, and upar expression of prostate cancer cells. PLoS One 2010; 5: e13428
    CrossrefPubMedGoogle Scholar
  • 156 Zimmerman J, Holick MF, Silver J. Normocalcemia in a hypoparathyroid patient with sarcoidosis: Evidence for parathyroid-hormone-independent synthesis of 1,25 dihydroxyvitamin d. Ann Intern Med 1983; 98: 338
  • 157 Grant WB, Mukayed M. Role of ultraviolet-b irradiance and vitamin d in reducing risk of cancer. In: Suba Z, ed. Recent Avenue to Cancer Prevention. Nova Science Publishers, Inc;. 2014. : 149-179
    Google Scholar
  • 158 Moukayed M, Grant WB. Molecular link between vitamin d and cancer prevention. Nutrients 2013; 5: 3993-4021
    CrossrefPubMedGoogle Scholar
  • 159 Wang Y, Zhu J, DeLuca HF. Where is the vitamin d receptor? Archives Biochemistry Biophysics 2012; 523: 123-133
    CrossrefPubMed
  • 160 Matthews D, LaPorta E, Zinser GM. et al. Genomic vitamin d signaling in breast cancer: Insights from animal models and human cells. J Steroid Biochem Mol Biol 2010; 121: 362-367
    CrossrefPubMedGoogle Scholar
  • 161 Welsh J. Targets of vitamin d receptor signaling in the mammary gland. J Bone Mineral Res 2007; 22 (Suppl. 2): V86-90
    CrossrefPubMedGoogle Scholar
  • 162 Steinfort DP, Tsui A, Grieve J. et al. Sarcoidal reactions in regional lymph nodes of patients with early stage non-small cell lung cancer predict improved disease-free survival: A pilot case-control study. Human Pathology 2012; 43: 333-338
    CrossrefPubMedGoogle Scholar
  • 163 Bolland MJ, Wilsher ML, Grey A. et al. Randomised controlled trial of vitamin d supplementation in sarcoidosis. BMJ Open 2013; 3: e003562
    CrossrefPubMedGoogle Scholar
  • 164 Kamphuis LS, Bonte-Mineur F, van Laar JA. et al. Calcium and vitamin d in sarcoidosis: Is supplementation safe? J Bone Mineral Res 2014; 29: 2498-2503
    CrossrefPubMed
  • 165 Von Helden R. Two cases of chronic sarcoidosis came in a prompt remission under a treatment with vitamin d. Poster-Presentation. Ed. Kongress Vitamin D Update, Charité Berlin; 2013
  • 166 Zittermann A, von Helden R, Grant W. et al. An estimate of the survival benefit of improving vitamin d status in the adult german population. Dermato-Endocrinology 2009; 1: 300-306
    PubMedGoogle Scholar
  • 167 Von Helden R. Hypothesis: Sarcoidosis is a useful defensive response to malignant cells. Treatment with vitamin d supports this defense process and can induce a spontaneous remission. Kongress Vitamin D Update, Charité Berlin: 2013