Thyroid Peroxidase Revisited – Whatʼs New?

Marlena Godlewska; Damian Gawel; Ashley M. Buckle; J. Paul Banga

doi:10.1055/a-1057-9469

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2019; 51(12): 765-769
DOI: 10.1055/a-1057-9469

Review

Thyroid Peroxidase Revisited – Whatʼs New?

Marlena Godlewska

¹Department of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, Warsaw, Poland

,

Damian Gawel

²Department of Immunohematology, Centre of Postgraduate Medical Education, Warsaw, Poland

,

Ashley M. Buckle

²Department of Immunohematology, Centre of Postgraduate Medical Education, Warsaw, Poland

¹Department of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, Warsaw, Poland

,

J. Paul Banga

⁴Kingʼs College London (Emeritus), London, UK

› Author Affiliations

Abstract

Thyroid peroxidase (TPO) is an enzyme that participates in thyroid hormone biosynthesis. TPO is also a major autoantigen in autoimmune thyroid diseases (AITD). In this review, we summarize the latest developments in the field of TPO research. We present the current understanding of immunodominant serologic determinants, frequency of TPO-specific autoantibodies in the population, as well as genetic and environmental factors contributing to their development. Moreover, we report recent progress in the clinical utilities of TPO autoantibody testing, including thyroid dysfunctions and extra-thyroidal disorders.

Key words

antibodies to thyroperoxidase - autoantibodies - autoimmunity - autoimmune thyroiditis - Gravesʼ disease - Hashimoto’s disease

Full Text

References

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