Serum Interleukin 23 in Psoriatic Arthritis Patients: Relation to
                    disease activity, physical function and health related quality of
                    life

Noha Abdelhalim Elsawy; Abdelmoniem Helal; Mohamed El Shafei; Neveen Lewis Mikhael; Nesrin Ahmed Aboeladl

doi:10.1055/a-1059-9475

Aktuelle Rheumatologie, Table of Contents

Aktuelle Rheumatologie 2020; 45(05): 460-466
DOI: 10.1055/a-1059-9475

Original Article

Serum Interleukin 23 in Psoriatic Arthritis Patients: Relation to disease activity, physical function and health related quality of life

Serum-Interleukin-23 bei Patienten mit Psoriasis-Arthritis: Zusammenhang mit Krankheitsaktivität, körperlicher Funktion und gesundheitsbezogener Lebensqualität

Noha Abdelhalim Elsawy

¹Physical medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

,

Abdelmoniem Helal

¹Physical medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

,

Mohamed El Shafei

²Radiodiagnosis Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

,

Neveen Lewis Mikhael

³Clinical and Chemical Pathology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

,

Nesrin Ahmed Aboeladl

⁴Rheumatology and Rehabilitation Department, Faculty of Medicine, Helwan University, Cairo, Egypt

› Author Affiliations

Abstract

Objective To assess interleukin 23 (IL-23) levels in the sera of psoriatic arthritis (PsA) patients and to determine the relationship of IL-23 with different disease activity indices, physical function and quality of life (QoL).

Methods Fifty PsA patients and 46 matched healthy controls were included in this study. Data including a detailed history, a thorough clinical examination, skin severity based on the Psoriasis Area and Severity Index (PASI), the Disease Activity index for Psoriatic Arthritis (DAPSA) and the Composite Psoriatic Disease Activity Index (CPDAI) were obtained for all patients. Physical function was assessed by the Health Assessment Questionnaire Disability Index (HAQ-DI) and health-related QoL was assessed using the Short Form Health Survey (SF-36), Psoriatic Arthritis Quality of Life (PsAQoL) and the Dermatology Life Quality Index (DLQI) were also assessed. Serum IL-23 levels were measured in the studied groups.

Results The study included 23(46%) females and 27 (54%) males with a mean age of 42.78±12.33 years. The mean serum IL-23 level was significantly higher in PsA patients (50.89±13.86 pg/ml) than in controls (43.88±6.34 pg/ml) (p=0.006). There were significant correlations between serum IL-23 levels and different grades of DAPSA activity (p=0.007) and PASI (p=0.015). No significant correlations could be detected between serum IL-23 levels and (HAQ-DI, DLQI, SF-36 or PsAQoL). CPDAI and DAPSA were significantly correlated with DLQI, SF-36 and PsAQoL.

Conclusion IL-23 is a useful biomarker for identifying joint activity or skin severity but not QoL or physical function.

Zusammenfassung

Ziel Beurteilung des Serumspiegels von Interleukin-23 (IL-23) bei Patienten mit Psoriasis-Arthritis (PsA) und Ermittlung des Zusammenhangs zwischen IL-23 und verschiedenen Krankheitsaktivitätsindizes, körperlicher Funktion und Lebensqualität (QoL).

Methoden In diese Studie wurden 50 PsA-Patienten und 46 vergleichbare gesunde Kontrollprobanden aufgenommen. Die bei allen Patienten durchgeführte Datenerhebung umfasste eine detaillierte Anamnese, eine sorgfältige klinische Untersuchung, Ermittlung des Schweregrads der Hautläsionen basierend auf dem Psoriasis Area and Severity Index (PASI), dem Disease Activity Index for Psoriatic Arthritis (DAPSA) und dem Composite Psoriatic Disease Activity Index (CPDAI). Die körperliche Funktion wurde anhand des Health Assessment Questionnaire Disability Index (HAQ-DI) und die gesundheitsbezogene Lebensqualität anhand des Short Form Health Survey (SF-36), des Psoriatic Arthritis Quality of Life (PsAQoL) und des Dermatology Life Quality Index (DLQI) beurteilt. In den untersuchten Gruppen wurden die Serumspiegel von IL-23 gemessen.

Ergebnisse Die Studie umfasste 23 (46 %) Frauen und 27 (54 %) Männer mit einem mittleren Alter von 42,78±12,33 Jahren. Der mittlere Serumspiegel von IL-23 war bei den PsA-Patienten (50,89±13,86 pg/ml) signifikant höher als bei den Kontrollprobanden (43,88±6,34 pg/ml) (p=0,006). Die Serumspiegel von IL-23 korrelierten signifikant mit verschiedenen Graden der mithilfe des DAPSA (p=0,007) und des PASI (p=0,015) ermittelten Krankheitsaktivität. Keine signifikanten Korrelationen fanden sich zwischen den IL-23-Serumspiegeln und HAQ-DI, DLQI, SF-36 oder PsAQoL. CPDAI und DAPSA korrelierten signifikant mit DLQI, SF-36 und PsAQoL.

Schlussfolgerung IL-23 ist ein nützlicher Biomarker zur Identifikation der Krankheitsaktivität oder des Schweregrads von Hautläsionen, aber nicht zur Ermittlung von Lebensqualität oder körperlicher Funktion.

Key words

PsA - IL-23 - DAPSA - SF-36 - PsAQoL

Schlüsselwörter

PsA - IL-23 - DAPSA - SF-36 - PsAQoL

Full Text

References

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