The Role of Tanycytes in the Hypothalamus-Pituitary-Thyroid Axis and
                    the Possibilities for Their Genetic Manipulation

Helge Müller-Fielitz; Markus Schwaninger

doi:10.1055/a-1065-1855

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2020; 128(06/07): 388-394
DOI: 10.1055/a-1065-1855

Mini-Review

The Role of Tanycytes in the Hypothalamus-Pituitary-Thyroid Axis and the Possibilities for Their Genetic Manipulation

Helge Müller-Fielitz

¹Institute for Experimental and Clinical Pharmacology and Toxicology, Lübeck, University of Lübeck, Germany

,

Markus Schwaninger

¹Institute for Experimental and Clinical Pharmacology and Toxicology, Lübeck, University of Lübeck, Germany

› Author Affiliations

Abstract

Thyroid hormone (TH) regulation is important for development, energy homeostasis, heart function, and bone formation. To control the effects of TH in target organs, the hypothalamus-pituitary-thyroid (HPT) axis and the tissue-specific availability of TH are highly regulated by negative feedback. To exert a central feedback, TH must enter the brain via specific transport mechanisms and cross the blood-brain barrier. Here, tanycytes, which are located in the ventral walls of the 3^rd ventricle in the mediobasal hypothalamus (MBH), function as gatekeepers. Tanycytes are able to transport, sense, and modify the release of hormones of the HPT axis and are involved in feedback regulation. In this review, we focus on the relevance of tanycytes in thyrotropin-releasing hormone (TRH) release and review available genetic tools to investigate the physiological functions of these cells.

Keywords

tanycytes - TRH - HPT axis - genetic tools - viral vectors - transgenic mice

Full Text

References

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