Das diffuse maligne peritoneale Mesotheliom (DMPM) – eine seltene Diagnose

Zusammenfassung

Das diffuse maligne peritoneale Mesotheliom (DMPM) ist eine seltene Diagnose. Es tritt häufiger bei Männern als bei Frauen auf. Die Symptome sind vor allem unspezifische abdominelle Beschwerden, was die Diagnosestellung erschwert. Die Ursachen des DMPM sind noch nicht ausreichend geklärt. Ca. 7 % der peritonealen Mesotheliome lassen sich auf eine Asbestexposition zurückführen. Das DMPM war bis zur Entwicklung des Therapiekonzepts der systematischen chirurgischen Zytoreduktion (CRS) und anschließenden hyperthermen intraperitonealen Chemotherapie (HIPEC) eine fatale Diagnose mit einer medianen Lebenserwartung von 4–13 Monaten. Mit der CRS und HIPEC verbesserte sich die Prognose des DMPM deutlich auf 30–92 Monate heutzutage. Das vorliegende Fallbeispiel stellt die heute mögliche Therapie und deren Ergebnisse vor.

Abstract

Diffuse malignant peritoneal mesothelioma (DMPM) is a rare diagnosis, found more frequently in men than in women. Symptoms are unspecific abdominal disorders making that diagnosis difficult to set. Causes of DMPM are yet to be discovered in entirety. Asbestos exposure is the reason for approximately 7 % of all peritoneal mesotheliomas. Until the evaluation of systematic cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) DMPM was a fatal diagnosis with a median overall survival (OS) of 4–13 months. The prognosis of DMPM dramatically improved with implementation of CRS and HIPEC to an OS of 30–92 month nowadys. CRS and HIPEC were performed in this case.

Schlüsselwörter

Malignes peritoneales Mesotheliom - Zytoreduktive Chirurgie - CRS - Hypertherme intraperitoneale Chemotherapie - HIPEC

Key words

malignant peritoneal mesothelioma - cytoreductive surgery - CRS - hyperthermic intraperitoneal chemotherapy - HIPEC

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