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Exp Clin Endocrinol Diabetes 2020; 128(06/07): 450-454
DOI: 10.1055/a-1088-1215
Mini-Review

Thyroid Hormone Actions and Bone Remodeling – The Role of the Wnt Signaling Pathway

Franziska Lademann
1   Department of Medicine III and Center for Healthy Aging, Technische Universität Dresden, Germany
,
Elena Tsourdi
1   Department of Medicine III and Center for Healthy Aging, Technische Universität Dresden, Germany
,
Lorenz C. Hofbauer
1   Department of Medicine III and Center for Healthy Aging, Technische Universität Dresden, Germany
,
Martina Rauner
1   Department of Medicine III and Center for Healthy Aging, Technische Universität Dresden, Germany
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Abstract

Thyroid hormones are indispensable for bone development and growth. Also in adults, bone mass maintenance is under the control of thyroid hormones. Preclinical and clinical studies established untreated hyperthyroidism as a cause for secondary osteoporosis with increased fracture risk. Thus, normal thyroid function is essential for bone health. Mechanistically, thyroid hormone excess accelerates bone turnover with predominant bone resorption. How thyroid hormones affect osteoblast and osteoclast functions, however, still remains ill-defined. The Wnt signaling pathway is a major determinant of bone mass and strength as it promotes osteoblastogenesis and bone formation, while inhibiting bone resorption. So far, only few studies investigated a possible link between thyroid hormones, bone metabolism and the Wnt pathway. In this review, we summarize the literature linking thyroid hormones to bone homeostasis through Wnt signaling and discuss its potential as a therapeutic approach to treat hyperthyroidism-induced bone loss.

Key words

thyroid hormones - thyroid disease - bone - bone turnover - Wnt signaling - sclerostin - dickkopf-1


Publication History

Received: 07 September 2019
Received: 16 December 2019

Accepted: 02 January 2020

Article published online:
20 January 2020

© Georg Thieme Verlag KG
Stuttgart · New York

 

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