Blonanserin patch vs. Other Antipsychotics for Acute Schizophrenia: A Systematic Review of Double-blind, Randomized, Placebo-controlled, Phase 3 Trials in Japan

Taro Kishi; Reiji Yoshimura; Yuki Matsuda; Kenji Sakuma; Nakao Iwata

doi:10.1055/a-1096-1266

Pharmacopsychiatry, Table of Contents

Pharmacopsychiatry 2020; 53(03): 122-132
DOI: 10.1055/a-1096-1266

Original Paper

Blonanserin patch vs. Other Antipsychotics for Acute Schizophrenia: A Systematic Review of Double-blind, Randomized, Placebo-controlled, Phase 3 Trials in Japan

Taro Kishi

¹Department of Psychiatry, Fujita Health University, Toyoake, Japan

,

Reiji Yoshimura

²Department of Psychiatry University of Occupational and Environmental Health Japan, Psychiatry, Kitakyushu, Japan

,

Yuki Matsuda

¹Department of Psychiatry, Fujita Health University, Toyoake, Japan

,

Kenji Sakuma

¹Department of Psychiatry, Fujita Health University, Toyoake, Japan

,

Nakao Iwata

¹Department of Psychiatry, Fujita Health University, Toyoake, Japan

› Author Affiliations

Abstract

Introduction The use of the blonanserin patch (BLO-P) for schizophrenia treatment was approved in Japan in 2019. This systematic review of trials in Japan assessed the efficacy and safety profile of BLO-P compared with other antipsychotics.

Methods The systematic review included 6-week, double-blind, randomized, placebo-controlled, phase 3 trials in Japan that included patients with acute schizophrenia. Pooled data for patients receiving BLO-P 40 and 80 mg/day (BLO-P40+80) were compared with pooled data for patients receiving asenapine 10 and 20 mg/day (ASE10+20) and data for those receiving brexpiprazole 2 mg/day (BRE2) and paliperidone extended-release 6 mg/day (PAL-ER6).

Results All the investigated treatments were superior to placebo in reducing the Positive and Negative Syndrome Scale (PANSS) total score; the Hedges’ g values (95% confidence interval) for BLO-P40+80, ASE10+20, BRE2, and PAL-ER6 were−0.40 (−0.58,−0.22),−0.61 (−0.79,−0.42),−0.33 (−0.60,−0.07), and−0.69 (−0.93,−0.45), respectively. There were differences among the antipsychotics in the incidence of various individual adverse events.

Discussion BLO-P40+80 may have a good efficacy/safety/tolerability profile for the treatment of patients with acute schizophrenia.

Keywords

asenapine - blonanserin patch - brexpiprzole - paliperidone extended-release - acute schizophrenia

Full Text

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Supplementary Material

Supplementary Material