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Klin Padiatr 2020; 232(02): 70-72
DOI: 10.1055/a-1108-1699
Short Communication
© Georg Thieme Verlag KG Stuttgart · New York

A Ventriculoperitoneal Shunt Infection Successfully Treated with Intraventricular Coadministration of Tigecycline and Colistin

Eine ventrikuloperitoneale Shunt-Infektion wurde erfolgreich mit gleichzeitiger Gabe von intraventrikulärem Tigecyclin und Colistin behandelt
Tuğçe Tural Kara 
1   Pediatric Infectious Disease, Hatay Antakya State Hospital, Antakya, Turkey
,
Murat Kocaoglu
2   Neurosurgery, Hatay Antakya State Hospital, Antakya, Turkey
› Institutsangaben
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Publikationsdatum:
10. März 2020 (online)

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Introduction

Hemophagocytic lymphohistiocytosis (HLH) is a systemic inflammatory disorder characterized by uncontrolled histiocytic proliferation, hemophagocytosis, macrophage activation, and up-regulation of inflammatory cytokines (Grom AA., Current opinion in rheumatology 2003; 15: 587–590). HLH is usually divided into two types: primary (familial) HLH and secondary (reactive) HLH. Primary HLH is associated with primary immune deficiencies in which specific gene mutations play an important role, such as perforin defects.