Primäre maligne Tumoren der Wirbelsäule

Primär maligne Tumoren der Wirbelsäule sind selten. Die klinische Untersuchung, eine umfassende Bildgebung sowie Kenntnis der vorliegenden Entität bilden die Voraussetzung zur Therapieplanung. Das interdisziplinäre Behandlungskonzept und anspruchsvolle chirurgische Techniken, zumeist als En-bloc-Resektion sowie dorsoventrale Spondylodese, erfordern die wirbelsäulenchirurgische und onkologische Expertise eines Tumorzentrums.

Schlüsselwörter

Sarkom - Osteosarkom - Knochentumor - spinaler Tumor - Chondrosarkom - Chordom - Ewing-Sarkom der Wirbelsäule - maligne Wirbelsäulentumoren - En-bloc-Spondylektomie - En-bloc-Vertebrektomie

• Literatur

• 1 Boriani S, De Iure F, Bandiera S. et al. Chondrosarcoma of the Mobile Spine. Spine (Phila Pa 1976) 2000; 25: 804-812 Im Internet (Stand: 14.04.2020): http://www.ncbi.nlm.nih.gov/pubmed/10751291
• 2 Kelley SP, Ashford RU, Rao AS. et al. Primary bone tumours of the spine: a 42-year survey from the Leeds Regional Bone Tumour Registry. Eur Spine J 2007; 16: 405-409 Im Internet (Stand: 14.04.2020): http://www.ncbi.nlm.nih.gov/pubmed/16865376
• 3 Mukherjee D, Chaichana KL, Gokaslan ZL. et al. Survival of patients with malignant primary osseous spinal neoplasms: results from the Surveillance, Epidemiology, and End Results (SEER) database from 1973 to 2003. J Neurosurg Spine 2011; 14: 143-150 Im Internet (Stand: 14.04.2020): http://www.ncbi.nlm.nih.gov/pubmed/21184634
• 4 Sundaresan N, Boriani S, Rothman A. et al. Tumors of the osseous spine. J Neurooncol 2004; 69: 273-290
• 5 Burningham Z, Hashibe M, Spector L. et al. The Epidemiology of sarcoma. Clin Sarcoma Res 2012; 2: 14 doi:10.1186/2045-3329-2-14
• 6 Kazandjian D. Multiple myeloma epidemiology and survival: A unique malignancy. Semin Oncol 2016; 43: 676-681
• 7 Schaser K-D, Melcher I, Luzzati A, Disch AC. Bone Sarcoma of the Spine. In: Tunn PU. ed. Treatment of Bone and soft Tissue Sarcomas. Berlin, Heidelberg: Springer; 2009: 141-167 Im Internet (Stand: 14.04.2020): http://www.ncbi.nlm.nih.gov/pubmed/19230539
• 8 Programm für Nationale VersorgungsLeitlinien der Bundesärztekammer, Kassenärztliche Bundesvereinigung, AWMF. Nationale VersorgungsLeitlinie Nicht-spezifischer Kreuzschmerz – Langfassung, 2. Auflage. Version 1. 2017. Im Internet: (Stand: 14.04.2020). https://www.leitlinien.de/nvl/kreuzschmerz
• 9 Weinstein JN. Surgical approach to spine tumors. Orthopedics 1989; 12: 897-905 Im Internet (Stand: 14.04.2020): http://www.ncbi.nlm.nih.gov/pubmed/2662149
• 10 Fisher CG, Rhines LD, Bettegowda C. et al. Introduction to focus issue II in spine oncology: Evidence-based medicine recommendations for spine oncology. Spine (Phila Pa 1976) 2016; 41: S159-S162
• 11 Åkerman M, Ryd W, Skytting B. Fine-needle aspiration of synovial sarcoma: Criteria for diagnosis: Retrospective reexamination of 37 cases, including ancillary diagnostics. A Scandinavian sarcoma group study. Diagn Cytopathol 2003; 28: 232-238 doi:10.1002/dc.10265
• 12 Ayala AG, Zornosa J. Primary bone tumors: percutaneous needle biopsy. Radiologic-pathologic study of 222 biopsies. Radiology 1983; 149: 675-679 Im Internet (Stand: 14.04.2020): http://www.ncbi.nlm.nih.gov/pubmed/6580673
• 13 Disch AC, Kleber C, Redemann D. et al. Current surgical strategies for treating spinal tumors: Results of a questionnaire survey among members of the German Spine Society (DWG). Eur J Surg Oncol 2019. Im Internet (Stand: 14.04.2020): https://www.sciencedirect.com/science/article/pii/S0748798319306535?via%3Dihub
• 14 Boriani S, Weinstein JN, Biagini R. Spine update primary bone tumors of the spine: Terminology and surgical staging. Spine (Phila Pa 1976) 1997; 22: 1036-1044
• 15 Tomita K, Kawahara N, Murakami H. et al. Total en bloc spondylectomy for spinal tumors: Improvement of the technique and its associated basic background. J Orthop Sci 2006; 11: 3-12
• 16 Dea N, Gokaslan Z, Choi D. et al. Spine oncology – primary spine tumors. Im Internet (Stand: 14.04.2020): Neurosurgery 2017; 80: S124-S130 http://www.ncbi.nlm.nih.gov/pubmed/28350941
• 17 Disch AC, Melcher I, Luzatti A. et al. Chirurgische Technik der En-bloc-Spondylektomie bei solitären Metastasen der thorakolumbalen Wirbelsäule. Unfallchirurg 2007; 110: 163-170 doi:10.1007/s00113-007-1233-7
• 18 Disch AC, Luzzati A, Melcher I. et al. Three-dimensional stiffness in a thoracolumbar en-bloc spondylectomy model: a biomechanical in vitro study. Clin Biomech 2007; 22: 957-964 http://www.ncbi.nlm.nih.gov/pubmed/17854958 Im Internet (Stand: 14.04.2020):
• 19 Disch AC, Schaser K-D, Melcher I. et al. Oncosurgical results of multilevel thoracolumbar en-bloc spondylectomy and reconstruction with a carbon composite vertebral body replacement system. Im Internet (Stand: 14.04.2020): Spine (Phila Pa 1976) 2011; 36: E647-E655 http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L51220860
• 20 Radeleff B, Eiers M, Lopez-Benitez R. et al. Transarterial embolization of primary and secondary tumors of the skeletal system. Eur J Radiol 2006; 58: 68-75
• 21 Itshayek E, Cohen JE, Yamada Y. et al. Timing of stereotactic radiosurgery and surgery and wound healing in patients with spinal tumors: a systematic review and expert opinions. Neurol Res 2014; 36: 510-523 http://www.ncbi.nlm.nih.gov/pubmed/24806339 Im Internet (Stand: 14.04.2020):
• 22 Melcher I, Disch AC, Khodadadyan-Klostermann C. et al. Primary malignant bone tumors and solitary metastases of the thoracolumbar spine: Results by management with total en bloc spondylectomy. Eur Spine J 2007; 16: 1193-1202
• 23 Blay J-Y, Honoré C, Stoeckle E. et al. Surgery in reference centers improves survival of sarcoma patients: a nationwide study. Ann Oncol 2019; 30: 1143-1153 Im Internet (Stand: 14.04.2020): http://www.ncbi.nlm.nih.gov/pubmed/31081028
• 24 Boriani S, Bandiera S, Biagini R. et al. Chordoma of the mobile spine: Fifty years of experience. Spine (Phila Pa 1976) 2006; 31: 493-503
• 25 Ailon T, Torabi R, Fisher CG. et al. Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: a Systematic Review. Spine (Phila Pa 1976) 2016; 41 (Suppl. 20) S193-S198
• 26 Dekutoski MB, Clarke MJ, Rose P. et al. Osteosarcoma of the spine: prognostic variables for local recurrence and overall survival, a multicenter ambispective study. Im Internet (Stand: 14.04.2020): J Neurosurg Spine 2016; 25: 59-68 https://thejns.org/view/journals/j-neurosurg-spine/25/1/article-p59.xml
• 27 Fisher CG, Versteeg AL, Dea N. et al. Surgical Management of Spinal Chondrosarcomas. Spine (Phila Pa 1976) 2016; 41: 678-685 Im Internet (Stand: 14.04.2020): http://www.ncbi.nlm.nih.gov/pubmed/26854656
• 28 Sciubba D, Okuno S, Dekutoski M. et al. Ewing and osteogenic sarcoma: evidence for multidisciplinary management. Im Internet (Stand: 14.04.2020): Spine (Phila Pa 1976) 2009; 34 (22 Suppl): S58-S68 https://insights.ovid.com/crossref?an=00007632-200910151-00009
• 29 Sciubba DM, Okuno SH, Dekutoski MB, Gokaslan ZL. Ewing and osteogenic sarcoma: evidence for multidisciplinary management. Spine 2009; 34: 58-68