Synchronization of Fibroblasts Ex Vivo in Psychopharmacology

Frank Faltraco; Adriana Uzoni; Liliia Shevchuk; Johannes Thome; Denise Palm

doi:10.1055/a-1151-4947

Pharmacopsychiatry, Table of Contents

Pharmacopsychiatry 2023; 56(03): 101-107
DOI: 10.1055/a-1151-4947

Review

Synchronization of Fibroblasts Ex Vivo in Psychopharmacology

Frank Faltraco

¹Department of Psychiatry and Psychotherapy, University Medical Center Rostock, Rostock, Germany

,

Adriana Uzoni

¹Department of Psychiatry and Psychotherapy, University Medical Center Rostock, Rostock, Germany

,

Liliia Shevchuk

¹Department of Psychiatry and Psychotherapy, University Medical Center Rostock, Rostock, Germany

,

Johannes Thome

¹Department of Psychiatry and Psychotherapy, University Medical Center Rostock, Rostock, Germany

,

Denise Palm

¹Department of Psychiatry and Psychotherapy, University Medical Center Rostock, Rostock, Germany

› Author Affiliations

Abstract

The central oscillator for the inner clock is the suprachiasmatic nuclei of the hypothalamus. Furthermore, many peripheral oscillators are present in tissues such as skin. Human derived fibroblasts provide an advantageous model to study circadian rhythmicity as well as the influence of pharmacological drugs on circadian gene expression. Importantly, the synchronization of the circadian system of fibroblasts can be done by different methods. The review presents an overview of the current knowledge of different synchronization methods mostly used in mice or rat fibroblasts. Furthermore, the review sums up and discusses the role of norepinephrine as a possible synchronizer agent.

Key words

fibroblasts - circadian rhythm - synchronization

Full Text

References

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