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DOI: 10.1055/a-1157-0615
Effects of Short Term Metformin Treatment on Brown Adipose Tissue Activity and Plasma Irisin Levels in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial
Funding: Research supported by Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG, grant # APQ-03798-16) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) through the National Institute of Hormones and Women's Health and the National Institute of Molecular Medicine. K.B.G and F.M.R. received research grants from CNPq.
Abstract
Polycystic ovary syndrome (PCOS) is a chronic dysfunction associated with obesity and metabolic disorders that can be ameliorated by treatment with metformin. Brown adipose tissue (BAT) has been recently identified in adult humans, and irisin is a myokine that induces BAT formation. The aim of this randomized controlled trial was to evaluate whether a short term treatment with metformin alters BAT activity and plasma irisin levels in women with PCOS. The participants were randomly assigned to receive metformin (1500 mg/day, n=21) or placebo (n=24) during 60 days. BAT activity was assessed by 18F-FDG positron emission tomography-computed tomography (PET-CT) and plasma irisin levels were measured by enzyme immunoassay. The groups were similar in age, body measures, metabolic profile and PCOS phenotypes. BAT activity did not change significantly in the women treated with metformin (median Δ SUVmax=–0.06 g/ml, interquartile interval –2.81 to 0.24 g/ml, p=0.484, Wilcoxon’s test) or placebo (median Δ SUVmax=0.98 g/ml, interquartile interval –2.94 to 4.60 g/ml, p=0.386). In addition, plasma irisin levels remained unchanged in the groups treated with metformin (median Δ=–98 ng/ml, interquartile interval –366 to 60 ng/ml, p=0.310) and placebo (median Δ=28 ng/ml, interquartile interval –1260 to 215 ng/ml, p=0.650). These results suggest that in PCOS women BAT activity and plasma irisin levels may not change after a brief treatment with metformin.
Publikationsverlauf
Eingereicht: 14. Januar 2020
Angenommen nach Revision: 06. April 2020
Artikel online veröffentlicht:
04. Mai 2020
© 2020. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
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