Mean Platelet Volume is Affected in Term Fetuses with Intrauterine Growth Restriction

Abstract

Objectives The aim of our study was to analyze the mean platelet volume levels as a potential marker of altered placentation in intrauterine growth restriction (IUGR) cases.

Methods A total of 126 term singleton pregnant women with IUGR fetuses and 345 healthy pregnant controls were recruited and compared.

Results The mean platelet volume was significantly higher in the IUGR group (10.8±0.9 fl) than the control group (9.9±1.1 fl) (p=0.03). The mean hemoglobin was lower in IUGR group (11.3 (8.3–14.5) g/dl) than the control group (11.9 (8.2–13.0) g/dl) (p=0.04). The optimal cut-off MPV for prediction of IUGR was ≥10.55 fl, with a sensitivity of 59% and a specificity of 75%.

Conclusion Increased MPV levels in term pregnant women may be particularly helpful for discrimination and prediction of high-risk fetuses when IUGR is suspected.

Key words

intrauterine growth restriction - mean platelet volume - hemoglobin count

Publikationsverlauf

Eingereicht: 03. März 2020

Angenommen: 03. Mai 2020

Artikel online veröffentlicht:
26. Juni 2020

• References

• 1 Sharma D, Farahbakhsh N, Shastri S. et al. Intrauterine growth restriction – part 2. J Matern Fetal Neonatal Med 2016; 29: 4037-4048 DOI: 10.3109/14767058.2016.1154525.
• 2 Mense L, Birdir C, Reichert J. et al. [Intrauterine growth restriction: transsectoral, interdisciplinary and multiprofessional care for pregnant women and newborns in a feto-neonatal pathway: a project of the innovationsfonds]. Z Geburtshilfe Neonatol 2020; 224: 15-21 DOI: 10.1055/a-0998-4532.
• 3 Sharma D, Shastri S, Farahbakhsh N. et al. Intrauterine growth restriction – part 1. J Matern Fetal Neonatal Med 2016; 29: 3977-3987 DOI: 10.3109/14767058.2016.1152249.
• 4 Lausten-Thomsen U, Olsen M, Greisen G. et al. Inflammatory markers in umbilical cord blood from small-for-gestational-age newborns. Fetal Pediatr Pathol 2014; 33: 114-118 DOI: 10.3109/15513815.2013.879239.
• 5 Noris P, Melazzini F, Balduini CL. New roles for mean platelet volume measurement in the clinical practice?. Platelets 2016; 27: 607-612 doi: 10.1080/09537104.2016.1224828
• 6 Huang HL, Chen CH, Kung CT. et al. Clinical utility of mean platelet volume and immature platelet fraction in acute coronary syndrome. Biomed J 2019; 42: 107-115 DOI: 10.1016/j.bj.2018.12.005.
• 7 Harrison P, Goodall AH. Studies on mean platelet volume (MPV) – new editorial policy. Platelets 2016; 27: 605-606 doi: 10.1080/09537104.2016.1225467
• 8 Maluf CB, Barreto SM, Vidigal PG. Standardization and reference intervals of platelet volume indices: insight from the Brazilian longitudinal study of adult health (ELSA-BRASIL). Platelets 2015; 26: 413-420 doi: 10.3109/09537104.2014.942620
• 9 Visan V, Anghelache-Lupascu I, Salavascu T. et al. Intrauterine growth restriction –predictive serum markers. Rev Med Chir Soc Med Nat Iasi 2016; 120: 173-177
• 10 Kanat-Pektas M, Yesildager U, Tuncer N. et al. Could mean platelet volume in late first trimester of pregnancy predict intrauterine growth restriction and pre-eclampsia?. J Obstet Gynaecol Res 2014; 40: 1840-1845 DOI: 10.1111/jog.12433.
• 11 Ureyen I, Ozyuncu O, Sahin-Uysal N. et al. Relationship of maternal mean platelet volume with fetal Doppler parameters and neonatal complications in pregnancies with and without intrauterine growth restriction. J Matern Fetal Neonatal Med 2017; 30: 471-474 DOI: 10.1080/14767058.2016.1175423.
• 12 Kumru P, Aka N, Köse G. et al. The value of mean platelet volume in predicting the severity of preeclampsia and of Hellp syndrome. Gynecol Obstet Reprod Med 2007; 13: 9-13
• 13 Piazze J, Gioia S, Cerekja A. et al. Doppler velocimetry alterations related to platelet changes in third trimester pregnancies. Platelets 2007; 18: 11-15 DOI: 10.1080/09537100600800347.