A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders

Sonu Kumar Yadav; Reshma Ir; Rajesh Jeewon; Mukesh Doble; Kevin D. Hyde; Ilango Kaliappan; Ravindrian Jeyaraman; Rambabu N. Reddi; Jayalakshmi Krishnan; Min Li; Siva Sundara Kumar Durairajan

doi:10.1055/a-1177-4834

Planta Medica, Table of Contents

Planta Med 2020; 86(16): 1161-1175
DOI: 10.1055/a-1177-4834

Biological and Pharmacological Activity

Reviews

A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders

Sonu Kumar Yadav‡

¹Division of Mycobiology and Neurodegenerative Disease Research, Department of Microbiology, School of Life Sciences, Central University of Tamil Nadu, Tiruvarur, India

,

Reshma Ir‡

¹Division of Mycobiology and Neurodegenerative Disease Research, Department of Microbiology, School of Life Sciences, Central University of Tamil Nadu, Tiruvarur, India

,

Rajesh Jeewon

²Department of Health Sciences, Faculty of Science, University of Mauritius, Reduit, Mauritius

,

Mukesh Doble

³Department of Biotechnology, Indian Institute of Technology Madras, Chennai, India

,

Kevin D. Hyde

⁴Center of Excellence in Fungal Research, Mae Fah Luang University, Chiang Rai, Thailand

,

Ilango Kaliappan

⁵Interdisciplinary Institute of Indian System of Medicine, SRM Institute of Science and Technology, Kattankulathur, India

,

Ravindrian Jeyaraman

⁶Corrosion and Materials Protection Division, CSIR-Central Electrochemical Research Institute, Karaikudi, India

,

Rambabu N. Reddi

⁷Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, Israel

,

Jayalakshmi Krishnan

⁸Department of Life Sciences, School of Life Sciences, Central University of Tamil Nadu, Tiruvarur, India

,

Min Li

⁹Mr. & Mrs. Ko Chi-Ming Centre for Parkinsonʼs Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China

,

Siva Sundara Kumar Durairajan ‡

¹Division of Mycobiology and Neurodegenerative Disease Research, Department of Microbiology, School of Life Sciences, Central University of Tamil Nadu, Tiruvarur, India

› Author Affiliations

Abstract

According to the World Health Organization, neurological and neurodegenerative diseases are highly debilitating and pose the greatest threats to public health. Diseases of the nervous system are caused by a particular pathological process that negatively affects the central and peripheral nervous systems. These diseases also lead to the loss of neuronal cell function, which causes alterations in the nervous system structure, resulting in the degeneration or death of nerve cells throughout the body. This causes problems with movement (ataxia) and mental dysfunction (dementia), both of which are commonly observed symptoms in Alzheimerʼs disease, Parkinsonʼs disease, Huntingtonʼs disease, and multiple sclerosis. Medicinal mushrooms are higher fungi with nutraceutical properties and are low in calories and fat. They are also a rich source of nutrients and bioactive compounds such as carbohydrates, proteins, fibers, and vitamins that have been used in the treatment of many ailments. Medicinal mushrooms such as Pleurotus giganteus, Ganoderma lucidium, and Hericium erinaceus are commonly produced worldwide for use as health supplements and medicine. Medicinal mushrooms and their extracts have a large number of bioactive compounds, such as polysaccharide β-glucan, or polysaccharide-protein complexes, like lectins, lactones, terpenoids, alkaloids, antibiotics, and metal-chelating agents. This review will focus on the role of the medicinal properties of different medicinal mushrooms that contain bioactive compounds with a protective effect against neuronal dysfunction. This information will facilitate the development of drugs against neurodegenerative diseases.

Key words

medicinal mushrooms - Cyathus - Sarcodon - Hericium - Antrodia - Ganoderma - Pleurotus - bioactive compounds - neurological disorder - neurodegenerative diseases

Full Text

References

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