Vererbung und Charakteristik der Pferdefarben: Weißzeichnungen

Weißzeichnungen beim Pferd sind Ausdruck fehlender Pigmentierung, die phänotypisch als einzelne weiße Haare, kleine weiße Flecken, moderate weiße Abzeichen über verschiedene Muster und Ausdehnungen bis hin zum fast weißen Pferd mit rosafarbener Haut in Erscheinung tritt. Pferde mit deutlichen Weißzeichnungen werden allgemein als Schecken bezeichnet.

Publikationsverlauf

Artikel online veröffentlicht:
15. September 2020

• Literatur

• 1 Aaron J. Thomas, Carol A. Erickson. The making of a melanocyte: the specification of melanoblasts from the neural crest. Pigment Cell & Melanoma 2008; 21 (06) 598-610 doi:10.1111/j.1755-148X.2008.00506.x
• 2 Goldgeier M, Klein L, Klein-Angerer S, Moellmann G, Nordlund J. The distribution of melanocytes in the leptomeninges of the human brain. J Investigat Dermatol 1984; 82 (03) 235-238 doi:10.1111/1523-1747.ep12260111
• 3 Yajima I, Larue L. The Location of Heart Melanocytes Is Specified and the Level of Pigmentation in the Heart May Correlate with Coat Color. Pigment Cell & Melanoma 2008; 21 (04) 471-476 doi:10.1111/j.1755-148X.2008.00483.x
• 4 Steel K, Barkway C. Another role for melanocytes: their importance for normal stria vascularis development in the mammalian inner ear. Developm 1989; 107 (03) 453-463
• 5 Kitamura Y, Hirotab S. Kit as a human oncogenic tyrosinekinase. Cellul Molecul Life Sci, 2004; 61: 2924-2931 doi:10.1007/s00018-004-4273-y
• 6 Mouse Genome Informatics. Online (Letzter Zugriff: 20.7.2020): http://www.informatics.jax.org/marker/key/10603
• 7 Brooks SA, Terry RB, Bailey EA. PCR-RFLP for KIT associated with tobiano spotting pattern in horses. Anim Genet 2002; 33: 301-303 doi:10.1046/j.1365-2052.2002.00854.x
• 8 Haase B, Jude R, Brooks SA, Leeb T. An equine chromosome 3 inversion is associated with the tobiano spotting pattern in German horse breeds. Anim Genet 2008; 39: 306-309 doi:10.1111/j.1365-2052.2008.01715.x
• 9 Brooks SA, Lear TL, Adelson DL, Bailey E. A chromosome inversion near the KIT gene and the Tobiano spotting pattern in horses. Cytogenet Genome Res 2007; 119: 225-230 doi:10.1159/000112065
• 10 Hintz HF, Van Vleck LD. Lethal dominant roan in horses. J Heredity 1979; 70: 145-146
• 11 Marklund S, Moller M, Sandberg K, Andersson L. Close association between sequence polymorphism in the KIT gene and the roan coat color in horses. Mamm Genome 1999; 10 (03) 283-288 doi:10.1007/s003359900987
• 12 Grilz-Seger G, Reiter S, Neuditschko M, Wallner B, Rieder S, Leeb T, Jagannathan V, Mesarič M, Cotman M, Pausch H, Lindgren G, Velie B, Horna M, Brem G, Druml T. A Genome-Wide Association Analysis in Noriker Horses Identifies a SNP Associated With Roan Coat Color. J Equine Vet Sci 2020; 8 DOI: 10.1016/j.jevs.2020.102950.
• 13 Voß K, Tetens J, Thaller G, Becker D. Coat Color Roan Shows Association with KIT Variants and No Evidence of Lethality in Icelandic Horses. Genes (Basel) 2020; 11 (06) E680 doi:10.3390/genes11060680
• 14 Brooks SA, Bailey E. Exon Skipping in the KIT Gene Causes a Sabino Spotting Pattern in Horses. Mamm Genome 2005; 16: 893-902 doi:10.1007/s00335-005-2472-y
• 15 Druml T, Grilz-Seger G, Neuditschko M, Horna M, Ricard A, Pausch H, Brem G. Novel insights into Sabino1 and splashed white coat color patterns in horses. Anim Genet 2018; 49: 249-253 doi:10.1111/age.12657
• 16 Brooks SA. Studies of genetic variation at the KIT Locus and white spotting patterns in the horse [Dissertation]. University of Kentucky; 2006: 479 Online: https://uknowledge.uky.edu/gradschool_diss/479
• 17 Haase B, Brooks SA, Schlumbaum A, Azor PJ, Bailey E, Alaeddine F, Mevissen M, Burger D, Poncet PA, Rieder S, Leeb T. Allelic Heterogeneity at the Equine KIT Locus in Dominant White (W) Horses. PLoS Genet 2007; 3: e195 doi:10.1371/journal.pgen.0030195
• 18 Haase B, Brooks SA, Tozaki T, Burger D, Poncet PA, Rieder S, Hasegawa T, Penedo C, Leeb T. Seven Novel KIT Mutations in Horses with White Coat Colour Phenotypes. Anim Genet 2009; 40 (05) 623-629 doi:10.1111/j.1365-2052.2009.01893.x
• 19 Holl H, Brooks S, Bailey E. De novo mutation of KIT discovered as a result of a non-hereditary white coat colour pattern. Animal Genetics 2010; 41 (02) 196-198 doi:DenovomutationofKITdiscoveredasaresultofanon-hereditarywhitecoatcolourpattern
• 20 Haase B, Rieder S, Tozaki T, Hasegawa T, Penedo MC, Jude R, Leeb T. Five novel KIT mutations in horses with white coat colour phenotypes. Anim Genet 2011; 42: 337-339 doi:10.1111/j.1365-2052.2011.02173.x
• 21 Hauswirth R, Jude R, Haase B, Bellone RR, Archer S, Holl H, Brooks SA, Tozaki T, Penedo MC, Rieder S, Leeb T. Novel variants in the KIT and PAX3 genes in horses with white-spotted coat colour phenotypes. Anim Genet 2013; 44: 763-765 doi:10.1111/age.12057
• 22 Haase B, Jagannathan V, Rieder S, Leeb T. A novel KIT variant in an Icelandic horse with white-spotted coat colour. Anim Genet 2015; 46: 46 doi:10.1111/age.12313
• 23 Dürig N, Jude R, Holl H, Brooks SA, Lafayette C, Jagannathan V, Leeb T. Whole genome sequencing reveals a novel deletion variant in the KIT gene in horses with white spotted coat colour phenotypes. Anim Genet 2017; 48: 483-485 doi:10.1111/age.12556
• 24 Holl HM, Brooks SA, Carpenter ML, Bustamante CD, Lafayette C. A novel splice mutation within equine KIT and the W15 allele in the homozygous state lead to all white coat color phenotypes. Anim Genet 2017; 48: 497-498 doi:10.1111/age.12554
• 25 Capomaccio S, Milanesi M, Nocelli C, Giontella A, Verini-Supplizi A, Branca M, Silvestrelli M, Cappelli K. Splicing site disruption in the KIT gene as strong candidate for white dominant phenotype in an Italian Trotter. Anim Genet 2017; 48: 727-728 doi:10.1111/age.12590
• 26 Hoban R, Castle K, Hamilton N, Haase B. Novel KIT variants for dominant white in the Australian horse population. Anim Genet 2018; 49 (01) 99-100 doi:10.1111/age.12627
• 27 Hug P, Jude R, Henkel J, Jagannathan V, Leeb T. A novel KIT deletion variant in a German Riding Pony with white-spotting coat colour phenotype. Anim Genet 2019; 50: 761-763 doi:10.1111/age.12840
• 28 Leeb T. Persönliche Mitteilung. 2020
• 29 Haase B, Obexer-Ruff G, Dolf G, Rieder S, Burger D, Poncet PA, Gerber V, Howard J, Leeb T. Haematological parameters are normal in dominant white Franches-Montagnes horses carrying a KIT mutation. Vet J 2009; 184 (03) 315-317 doi:10.1016/j.tvjl.2009.02.017