Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum

Asshaima Paramita Devi; Thuc-Huy Duong; Solenn Ferron; Mehdi A. Beniddir; Minh-Hiep Dinh; Van-Kieu Nguyen; Nguyen-Kim-Tuyen Pham; Dinh-Hung Mac; Joël Boustie; Warinthorn Chavasiri; Pierre Le Pogam

doi:10.1055/a-1203-0623

Planta Medica, Table of Contents

Planta Med 2020; 86(16): 1216-1224
DOI: 10.1055/a-1203-0623

Biological and Pharmacological Activity

Original Papers

Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum

Asshaima Paramita Devi^*

¹Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, Thailand

²Program in Biotechnology, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, Thailand

,

Thuc-Huy Duong^*

³Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City, Vietnam

,

Solenn Ferron

⁴Université Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes) – UMR 6226, Rennes, France

,

Mehdi A. Beniddir

⁵Équipe «Pharmacognosie-Chimie des Substances Naturelles», BioCIS, Université Paris-Sud, CNRS, Université Paris-Saclay, Châtenay-Malabry, France

,

Minh-Hiep Dinh

⁶Management Board of Ho Chi Minh City Agricultural Hi-Tech Park, Binh Thanh, Ho Chi Minh City, Vietnam

,

Van-Kieu Nguyen

⁷Institute of Fundamental and Applied Sciences, Duy Tan University, Ho Chi Minh City, Vietnam

⁸Faculty of Natural Sciences, Duy Tan University, Da Nang, Vietnam

,

Nguyen-Kim-Tuyen Pham

⁹Faculty of Environmental Science, Sai Gon University, Vietnam

,

Dinh-Hung Mac

¹⁰Department of Organic Chemistry, VNU University of Science, Hoan Kiem, Hanoi, Vietnam

,

Joël Boustie

⁴Université Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes) – UMR 6226, Rennes, France

,

Warinthorn Chavasiri^**

¹Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, Thailand

,

Pierre Le Pogam ^**

⁵Équipe «Pharmacognosie-Chimie des Substances Naturelles», BioCIS, Université Paris-Sud, CNRS, Université Paris-Saclay, Châtenay-Malabry, France

› Author Affiliations

Abstract

Three new depsidones, parmosidones F – G (1 – 2), and 8′-O-methylsalazinic acid (3), and 3 new diphenylethers, parmetherines A – C (4 – 6), together with 2 known congeners were isolated from the whole thalli of Parmotrema dilatatum, a foliose chlorolichen. Their structures were unambiguously determined by extensive spectroscopic analyses and comparison with literature data. The isolated polyphenolics were assayed for their α-glucosidase inhibitory activities. Newly reported benzylated depsidones 1 and 2 in particular inhibited α-glucosidase with IC₅₀ values of 2.2 and 4.3 µM, respectively, and are thus more potent than the positive control, acarbose.

Key words

depsidones - Diphenylethers - α-glucosidase - Lichens - Polyphenolics - Parmotrema dilatatum

Full Text

References

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