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CC BY-NC-ND 4.0 · Horm Metab Res 2020; 52(11): 809-814
DOI: 10.1055/a-1216-4405
Endocrine Care

No Independent Association of Circulating Fetuin-A with Insulin Sensitivity in Young Women

Sabrina Reif
1   Diabetes Research Group, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany
2   Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, Germany
3   German Center for Diabetes Research (DZD), Neuherberg, Germany
,
Sarah Moschko
1   Diabetes Research Group, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany
2   Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, Germany
3   German Center for Diabetes Research (DZD), Neuherberg, Germany
,
Christina Gar
1   Diabetes Research Group, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany
2   Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, Germany
3   German Center for Diabetes Research (DZD), Neuherberg, Germany
,
Uta Ferrari
1   Diabetes Research Group, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany
2   Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, Germany
3   German Center for Diabetes Research (DZD), Neuherberg, Germany
4   Department of Geriatrics, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany
,
Nina Hesse
5   Klinik und Poliklinik für Radiologie, Klinikum der Universität München, München, Germany
,
Nora N. Sommer
5   Klinik und Poliklinik für Radiologie, Klinikum der Universität München, München, Germany
,
Jochen Seißler
1   Diabetes Research Group, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany
2   Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, Germany
3   German Center for Diabetes Research (DZD), Neuherberg, Germany
,
Andreas Lechner
1   Diabetes Research Group, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany
2   Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, Germany
3   German Center for Diabetes Research (DZD), Neuherberg, Germany
› Author Affiliations Funding Information: German Center for Diabetes Research; Helmholtz Zentrum München; Klinikum der Universität München
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Abstract

Animal data link high circulating fetuin-A to low insulin sensitivity and observational studies identify the hepatokine as a marker of future incident type 2 diabetes mellitus in humans. However, a recent, well-powered Mendelian randomization study finds no causal role. We therefore tested in a deeply-phenotyped human cohort if circulating fetuin-A correlates independently with insulin sensitivity and how it relates to the metabolic syndrome and ectopic fat deposition. We analyzed data from 290 young women with and without recent gestational diabetes mellitus. We found that circulating fetuin-A correlates inversely with insulin sensitivity in univariate analyses, but that this correlation is lost after adjustment for markers of the metabolic syndrome and of fatty liver. Additionally, we investigated which fat compartment associates most strongly with circulating fetuin-A. In whole body MRI data from a subcohort of 152 women, this was liver fat content. We conclude that high circulating fetuin-A occurs as part of the metabolic syndrome in young women and associates most strongly with liver fat content. Its close link to the metabolic syndrome may also cause the inverse correlation of circulating fetuin-A with insulin sensitivity as we found no independent association.

Key words

type 2 diabetes - metabolic syndrome - non-alcoholic fatty liver disease - mineral metabolism

Supplementary Material



Publication History

Received: 20 January 2020

Accepted after revision: 08 July 2020

Article published online:
06 August 2020

© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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