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Phlebologie 2021; 50(01): e5-e6
DOI: 10.1055/a-1217-0961
Letter to the editor

Letter to the Editor regarding Lipoedema – myths and facts, Part 1 and Part 5. European Best Practice of Lipoedema – Summary of the European Lipoedema Forum consensus. Phlebologie 2020; 49: 31–49

Karen L. Herbst
1   Karen L. Herbst, MD, PC, Los Angeles, CA, USA
2   The US Standard of Care Committee
,
Linda Anne Kahn
2   The US Standard of Care Committee
3   Lymphatic Therapy Services, San Diego, CA, USA
,
Emily Iker
2   The US Standard of Care Committee
4   Lymphedema Center, Santa Monica, CA, USA
,
Rachelle Crescenzi
5   Vanderbilt University Medical Center, Nashville, TN, USA
,
Chuck Ehrlich
2   The US Standard of Care Committee
6   Lymph Notes, San Francisco, CA, USA
,
Tami Faris
2   The US Standard of Care Committee
7   Independent Contractor, Kansas City, KS, USA
,
Thomas Wright
2   The US Standard of Care Committee
8   Lipedema Surgical Solutions, O Fallon, MS, USA
,
Lindy McHutchison
2   The US Standard of Care Committee
9   The Lipedema Center, Carolina Vein Center, Durham, NC, USA
,
Jaime Schwartz
2   The US Standard of Care Committee
10   USC Keck School of Medicine, Los Angeles, CA, USA
,
Erik Lontok
2   The US Standard of Care Committee
11   Barth Syndrome Foundation, Larchmont, NY, USA
,
Michael S. Schwartz
2   The US Standard of Care Committee
12   Pasadena Plastic Surgery, Pasadena, CA, USA
,
Molly Sleigh
2   The US Standard of Care Committee
13   Lighthouse Lymphedema Network, Atlanta, GA, USA
,
Steven M. Dean
2   The US Standard of Care Committee
14   The Ohio State University Wexner Medical Center, Columbus, OH, USA
,
John R. Bartholomew
2   The US Standard of Care Committee
15   Cleveland Clinic, Cleveland, OH, USA
,
Polly Armour
2   The US Standard of Care Committee
16   Research Coordinator, Fat Disorders Resource Society, Illinois, USA
,
Margarita Correa-Perez
2   The US Standard of Care Committee
17   Physical Medicine Institute, Orlando, FL, US
,
Kathleen H. Lisson
2   The US Standard of Care Committee
18   Solace Massage and Mindfulness, San Diego, California, USA
,
Ingrid A. Harten
19   Benaroya Research Institute at Virginia Mason, Seattle, WA, USA
,
Nicholas Pennings
2   The US Standard of Care Committee
20   Campbell University School of Osteopathic Medicine, Buies Creek, NC, USA
,
Ethan Larson
2   The US Standard of Care Committee
21   Larson Plastic Surgery, Tucson, AZ, USA
,
Andrea Brennan
22   Brennan School-Casley-Smith USA, Scottsdale, AZ, USA
,
Joachim Zuther
23   Academy of Lymphatic Studies, Sebastian, FL USA
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Lipedema is a disease of loose connective tissue (LCT)-not just fat. Constituents of LCT include cells and an extracellular matrix of collagen fibers around glycosaminoglycans (GAGs) bound to sodium and water.



Publication History

Article published online:
01 October 2020

© 2020. Thieme. All rights reserved.

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Letter to this article:

Lipoedema – myths and facts, Part 5Phlebologie 2020; 49(01): 31-50
DOI: 10.1055/a-1012-7670

Letter to this article:

Leserbrief zu: Zetzmann K, Ludolph I, Horch R, et al. Bildgebende Diagnostik zur Therapieplanung bei Lip- und Lymphödem. Phlebologie 2020; 2(49): 72–78Phlebologie 2021; 50(01): e1-e2
DOI: 10.1055/a-1217-0973

Letter to this article:

Erwiderung auf den Leserbrief zu Lipoedema – myths and facts Part 1 and 5. European Best Practice of Lipoedema – Summary of the European Lipoedema Consensus, Phlebologie 2020; 49: 31–49Phlebologie 2021; 50(01): e7-e11
DOI: 10.1055/a-1250-3334

 

  • References

  • 1 Bertsch T, Erbacher G, Corda D. et al. Lipoedema – myths and facts, Part 5. European Best Practice of Lipoedema – Summary of the European Lipoedema Forum consensus. Phlebologie 2020; 49: 31-49
    Thieme ConnectSearch in Google Scholar
  • 2 Mortimer PS, Levick JR. Chronic peripheral oedema: the critical role of the lymphatic system. Clin Med (Lond) 2004; 4: 448-453
    CrossrefSearch in Google Scholar
  • 3 AL-Ghadban S, Cromer W, Allen M. et al Dilated Blood and Lymphatic Microvessels, Angiogenesis, Increased Macrophages, and Adipocyte Hypertrophy in Lipedema Thigh Skin and Fat Tissue. J Obes 2019; 2019: 8747461 . doi:10.1155/2019/8747461. eCollection 2019. PMID: 30949365
    CrossrefPubMedSearch in Google Scholar
  • 4 Curri SB, Merlen JF. Troubles Microvasculaires de Tissu Adipeux. Journal des Maladies Vasculaires (Paris) 1986; 11: 303-309
    PubMedSearch in Google Scholar
  • 5 Suga H, Araki J, Aoi N. et al. Adipose tissue remodeling in lipedema: adipocyte death and concurrent regeneration. J Cutan Pathol 2009; 3: 3
    Search in Google Scholar
  • 6 Felmerer G, Stylianaki A, Hägerling R. et al. Adipose Tissue Hypertrophy, An Aberrant Biochemical Profile and Distinct Gene Expression in Lipedema. J Surg Res 2020; 253: 294-303
    CrossrefPubMedSearch in Google Scholar
  • 7 Herbst KL. Lipedema is not just fat. https://www.lipedema.com/lipedema-is-not-just-fat2020
  • 8 Crescenzi R, Donahue PMC, Weakley S. et al. Lipedema and Dercum’s Disease: A New Application of Bioimpedance. Lymphat Res Biol 2019; 17: 671-679
    CrossrefPubMedSearch in Google Scholar
  • 9 Ward L, Winall A, Isenring E. et al. Assessment of bilateral limb lymphedema by bioelectrical impedance spectroscopy. Int J Gynecol Cancer 2011; 21: 409-418
    CrossrefPubMedSearch in Google Scholar
  • 10 Crescenzi R, Marton A, Donahue PMC. et al. Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema. Obesity (Silver Spring) 2018; 26: 310-317
    CrossrefPubMedSearch in Google Scholar
  • 11 Reed RK, Rubin K. Transcapillary exchange: role and importance of the interstitial fluid pressure and the extracellular matrix. Cardiovasc Res 2010; 87: 211-217
    CrossrefPubMedSearch in Google Scholar
  • 12 Foldi E, Foldi M. Lipedema. In: Foldi M, Foldi E. Hrsg. Foldi's Textbook of Lymphology. 551. Munich, Germany: Elsevier GmbH; 2006
    Search in Google Scholar
  • 13 Harwood CA, Bull RH, Evans J. et al. Lymphatic and venous function in lipoedema. Br J Dermatol 1996; 134: 1-6
    CrossrefPubMedSearch in Google Scholar
  • 14 Herbst K, Mirkovskaya L, Bharhagava A. et al. Lipedema Fat and Signs and Symptoms of Illness, Increase with Advancing Stage. Archives of Medicine 2015; 7: 1-8
    Search in Google Scholar
  • 15 Beltran K, Herbst KL. Differentiating lipedema and Dercum's disease. Int J Obes (Lond) 2017; 41: 240-245
    CrossrefPubMedSearch in Google Scholar
  • 16 Roberts MA, Mendez U, Gilbert RJ. et al. Increased Hyaluronan Expression at Distinct Time Points in Acute Lymphedema. Lymphatic Research and Biology 2012; 10: 122-128
    CrossrefPubMedSearch in Google Scholar
  • 17 Varaliová Z, Vlasák R, Čížková T. et al. Lymphatic drainage affects lipolytic activity of femoral adipose tissue in women. Int J Obes 2020; 5: 020-0559
    Search in Google Scholar
  • 18 Szolnoky G, Nagy N, Kovacs RK. et al. Complex decongestive physiotherapy decreases capillary fragility in lipedema. Lymphology 2008; 41: 161-166
    PubMedSearch in Google Scholar
  • 19 Casley-Smith JR, Casley-Smith JR. Modern Treatment for Lymphoedema. Fifth, revised Edition. South Australia: The Lymphoedema Association of Australia, Inc; 1997
    Search in Google Scholar
  • 20 Szolnoky G, Varga E, Varga M. et al. Lymphedema treatment decreases pain intensity in lipedema. Lymphology 2011; 44: 178-182
    PubMedSearch in Google Scholar
  • 21 Herbst KL, Ussery C, Eekema A. Pilot study: whole body manual subcutaneous adipose tissue (SAT) therapy improved pain and SAT structure in women with lipedema. Horm Mol Biol Clin Investig 2017 33.
    Search in Google Scholar
  • 22 Ibarra M, Eekema A, Ussery C. et al. Subcutaneous adipose tissue therapy reduces fat by dual X-ray absorptiometry scan and improves tissue structure by ultrasound in women with lipoedema and Dercum disease. Clin Obes 2018; 8: 398-406
    CrossrefPubMedSearch in Google Scholar
  • 23 Wold LE, Hines Jr EA, Allen EV. Lipedema of the legs; a syndrome characterized by fat legs and edema. Ann Intern Med 1951; 34: 1243-1250
    Search in Google Scholar
  • 24 Ma W, Gil HJ, Escobedo N. et al. Platelet factor 4 is a biomarker for lymphatic-promoted disorders. JCI Insight 2020; 11: 135109
    CrossrefPubMedSearch in Google Scholar
  • 25 Forner-Cordero I, Olivan-Sasot P, Ruiz-Llorca C. et al. Lymphoscintigraphic findings in patients with lipedema. Rev Esp Med Nucl Imagen Mol 2018; 37: 341-348
    PubMedSearch in Google Scholar
  • 26 Witte MH, Witte CL. Massive obesity simulating lymphedema. New England Journal of Medicine 1992; 327: 1927
    CrossrefSearch in Google Scholar
  • 27 Bast JH, Ahmed L, Engdahl R. Lipedema in patients after bariatric surgery. Surg Obes Relat Dis 2016; 12: 1131-1132
    CrossrefPubMedSearch in Google Scholar
  • 28 Pouwels S, Huisman S, Smelt HJM. et al. Lipoedema in patients after bariatric surgery: report of two cases and review of literature. Clin Obes 2018; 8: 147-150
    CrossrefPubMedSearch in Google Scholar
  • 29 Pouwels S, Smelt HJ, Said M. et al. Mobility Problems and Weight Regain by Misdiagnosed Lipoedema After Bariatric Surgery: Illustrating the Medical and Legal Aspects. Cureus 2019; 11: e5388
    PubMedSearch in Google Scholar
  • 30 Dudek JE, Bialaszek W, Ostaszewski P. et al. Depression and appearance-related distress in functioning with lipedema. Psychol Health Med 2018; 3: 1-8
    Search in Google Scholar
  • 31 Bertsch T, Erbacher G. Lipoedema – myths and facts Part 1. Phlebologie 2018; 47: 84-92
    Thieme ConnectSearch in Google Scholar