Status of Sentinel Lymph Node Biopsy in Endometrial Cancer

Florin Andrei Taran; Lisa Jung; Julia Waldschmidt; Sarah Isabelle Huwer; Ingolf Juhasz-Böss

doi:10.1055/a-1228-6189

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2021; 81(05): 562-573
DOI: 10.1055/a-1228-6189

GebFra Science

Review/Übersicht

Stellenwert der Sentinellymphonodektomie beim Endometriumkarzinom

Article in several languages: English | deutsch

Florin Andrei Taran

Klinik für Frauenheilkunde, Universitätsklinikum Freiburg, Freiburg, Germany

,

Lisa Jung

Klinik für Frauenheilkunde, Universitätsklinikum Freiburg, Freiburg, Germany

,

Julia Waldschmidt

Klinik für Frauenheilkunde, Universitätsklinikum Freiburg, Freiburg, Germany

,

Sarah Isabelle Huwer

Klinik für Frauenheilkunde, Universitätsklinikum Freiburg, Freiburg, Germany

,

Ingolf Juhasz-Böss

Klinik für Frauenheilkunde, Universitätsklinikum Freiburg, Freiburg, Germany

› Author Affiliations

Abstract

Zusammenfassung

Eine der größten Kontroversen im Management des Endometriumkarzinoms bleibt die Rolle der Lymphonodektomie im Rahmen des operativen Stagings. Das Konzept des Sentinellymphknoten-Verfahrens beim Endometriumkarzinom wird bereits seit mehreren Jahren evaluiert – mit vielversprechenden Sensitivitätsraten und negativen Vorhersagewerten. Die Möglichkeit des adäquaten Stagings unter Verzicht auf eine systematische Lymphonodektomie führt zu einer wesentlichen Reduktion der peri- und postoperativen Morbiditätsrate. Dennoch ist der Stellenwert der Sentinellymphonodektomie beim Endometriumkarzinom bislang noch nicht gänzlich geklärt und wird international unterschiedlich bewertet. Gemäß den geltenden europäischen Leitlinien und Empfehlungen sollte die Sentinellymphonodektomie beim Endometriumkarzinom nur im Rahmen von klinischen Studien durchgeführt werden. Im Rahmen dieser Übersichtsarbeit werden die Entwicklungen der letzten Dekade prägnant erläutert. Des Weiteren wird die aktuelle Datenlage hinsichtlich technischer Aspekte, Genauigkeit und prognostischer Relevanz der Sentinellymphonodektomie erläutert und kritisch bewertet.

Schlüsselwörter

Endometriumkarzinom - Sentinellymphknoten - Sentinel-Mapping - Ultrastaging

Full Text

References

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