Abstract
The present study was aimed to evaluate the association of lipoprotein lipase
(LPL) gene (S447X and Hind III) polymorphisms and T2DM. Relevant studies were
identified through systematic search PubMed, Cochrane Library, Embase, Wanfang,
CNKI databases. A total of 22 studies (8 studies for LPL S447X and 14 studies
for Hind III) were included. The results showed that the LPL S447X polymorphism
was associated with the low risk of T2DM under dominant and allelic genetic
models. Subgroup analysis by ethnicity showed that the LPL S447X polymorphism
was associated with a decreased risk of T2DM in the Asian population (under
dominant, heterozygous and allelic genetic models). In addition, we found that X
allele carriers of S447X polymorphism is associated with low levels of TC, TG,
and LDL. In subgroup analysis, Hind III polymorphism was associated with low
risk of T2DM in Asian populations (under dominant, heterozygote, allele genetic
models). Moreover, the carriers of H allele of Hind III have lower levels of TG,
and higher levels of HDL-C. This meta-analysis demonstrated that 447X carriers
and H allele in LPL gene associated with low risk of T2DM, which may due to in
part to the change of serum level of TC, TG, LDL, and HDL.
Key words
lipoprotein lipase - polymorphism - type 2 diabetes mellitus - S447X - Hind III
