COVID-19 and Sodium-Glucose Cotransporter 2 Inhibitors: No Fear to
                    Attempt?

Stella Papachristou; Theano Penlioglou; Anca Pantea Stoian; Nikolaos Papanas

doi:10.1055/a-1235-5617

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 2022; 130(03): 198-199
DOI: 10.1055/a-1235-5617

Commentary

COVID-19 and Sodium-Glucose Cotransporter 2 Inhibitors: No Fear to Attempt?

Stella Papachristou

¹Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece

,

Theano Penlioglou

¹Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece

,

Anca Pantea Stoian

²Diabetes, Nutrition and Metabolic Diseases Department, “Carol Davila” University of Medicine, Bucharest, Romania

,

Nikolaos Papanas

¹Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece

› Institutsangaben

Abstract

Novel coronavirus infectious disease (COVID-19) has been recognised as a pandemic by the World Health Organization (WHO) [1]. Mortality and morbidity are higher in elderly individuals and those with comorbidities, such as diabetes mellitus (DM), obesity, hypertension, respiratory tract diseases, coronary heart disease or cancer [1]. Indeed, two thirds of individuals who died from COVID-19 had DM in Italy [2].

Key words

diabetes - autoimmunity - COVID-19 - SGLT-2 inhibitors - treatment

Volltext

Referenzen

References
1 Wang D, Hu B, Hu C. et al. Clinical Characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA 2020; 323: 1061-1069
2 Remuzzi A, Remuzzi G. COVID-19 and Italy: what next?. Lancet 2020; 395: 1225-1228
3 Chen C, Chen C, Yan JT. et al Analysis of myocardial injury in patients with COVID-19 and association between concomitant cardiovascular diseases and severity of COVID-19. Zhonghua Xin Xue Guan Bing Za Zhi 2020; 48: E008
4 Cheng Y, Luo R, Wang K. et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int 2020; 97: 829-838
5 Ceriello A. Hyperglycemia and the worse prognosis of COVID-19. Why a fast blood glucose control should be mandatory. Diabetes Res Clin Pract 2020; 163: 108186
6 Penlioglou T, Papachristou S, Papanas N. COVID-19 and diabetes mellitus: May old anti-diabetic agents become the new philosopher’s stone?. Diabetes Ther 2020; 11: 1-3
7 Zelniker TA, Wiviott SD, Raz I. et al. SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: A systematic review and meta-analysis of cardiovascular outcome trials. Lancet 2019; 393: 31-39
8 US National Library of Medicine. Dapagliflozin in respiratory failure in patients with COVID-19; DARE-19. https://clinicaltrials.gov/ct2/show/NCT04350593. Last accessed: 01 August 2020
9 US National Library of Medicine. MulTi-Arm Therapeutic Study in Pre-ICu Patients Admitted With Covid-19 - Experimental Drugs and Mechanisms. https://clinicaltrials.gov/ct2/show/NCT04393246. Last accessed: 01 August 2020
10 Packer M. Do sodium-glucose co-transporter 2 inhibitors prevent heart failure with a preserved ejection fraction by counterbalancing the effects of leptin?. Diabetes Obes Metab 2018; 20: 1361-1366
11 Tsioufis C, Andrikou E, Thomopoulos C. et al Oral glucose-lowering drugs and cardiovascular outcomes: from the negative RECORD and ACCORD to neutral TECOS and promising EMPA-REG. Curr Vasc Pharmacol 2017; 15: 457-468
12 Iannaccone G, Scacciavillani R, Del Buono MG et al. Weathering the cytokine storm in COVID-19: therapeutic implications. Cardiorenal Med 2020; June 29 [Epub ahead of print]
13 Gonzalez-Rubio J, Navarro-Lopez C, Lopez-Najera E. et al. Cytokine release syndrome (CRS) and nicotine in COVID-19 patients: Trying to calm the storm. Front Immunol 2020; 11: 1359
14 Kawanami D, Matoba K, Takeda Y. et al. SGLT2 inhibitors as a therapeutic option for diabetic nephropathy. Int J Mol Sci 2017; 18: 1083
15 Shakespeare W. Measure for Measure. In: Wells S, Taylor G, Eds. The complete works of William Shakespeare 1^st Edition. Oxford University Press; Oxford: 1988: 794