Download PDF
Endoscopy 2021; 53(07): 739-743
DOI: 10.1055/a-1250-7786
Innovations and brief communications

Endoscopic ultrasound-guided radiofrequency ablation of pancreatic microcystic serous cystic neoplasms: a retrospective study

Dongwook Oh   *
1   Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Sung Woo Ko   *
2   Department of Gastroenterology, The Catholic University of Korea, Eunpyeong St. Mary's Hospital, Seoul, South Korea
,
Dong-Wan Seo
1   Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Seung-Mo Hong
3   Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Jin Hee Kim
4   Department of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Tae Jun Song
1   Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Do Hyun Park
1   Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Sung Koo Lee
1   Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
,
Myung-Hwan Kim
1   Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
› Author AffiliationsThis study was supported by a grant from the Korean Health Technology R & D project, Ministry of Health & Welfare, Republic of Korea (HI16C1163).
› Further Information
Also available at
    Permissions and Reprints

See also:

Reply to Lorenzo et al.Endoscopy 2021; 53(06): 667-667
DOI: 10.1055/a-1345-8614

Referred to by:

Author commentary on Dongwook Oh et al.Endoscopy 2021; 53(07): v35-v35
DOI: 10.1055/a-1282-5664

Abstract

Background Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) has been increasingly used for the management of various solid pancreatic tumors. This study aimed to evaluate the feasibility and safety of EUS-RFA for serous cystic neoplasms (SCNs).

Methods 13 patients with microcystic SCNs with honeycomb appearance underwent EUS-RFA using a 19-gauge RFA needle. Before ablation, cystic fluid was aspirated until a thin layer of fluid remained.

Results EUS-RFA was successful in all patients. Seven patients underwent a single session and the remaining six patients underwent a second session of EUS-RFA. One patient (7.7 %) experienced self-limited abdominal pain after EUS-RFA. During a median follow-up period of 9.21 months (interquartile range [IQR] 5.93 – 15.38), the median volume of the SCNs decreased from 37.82 mL (IQR 15.03 – 59.53) at baseline to 10.95 mL (IQR 4.79 – 32.39) at the end of follow-up. A radiologic partial response was achieved in eight patients (61.5 %).

Conclusions EUS-RFA is technically feasible and showed an acceptable rate of adverse events for patients with SCNs. A long-term follow-up study is required to evaluate the efficacy of EUS-RFA.

* Equal first authors


Supplementary material



Publication History

Received: 08 April 2020

Accepted: 05 August 2020

Article published online:
15 October 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

Letter to this article:

Radiofrequency ablation of pancreatic serous cystic neoplasms: feasibility, but for the wrong indicationEndoscopy 2021; 53(06): 666-666
DOI: 10.1055/a-1323-2782

 

  • References

  • 1 Oh HC, Seo DW, Lee TY. et al. New treatment for cystic tumors of the pancreas: EUS-guided ethanol lavage with paclitaxel injection. Gastrointest Endosc 2008; 67: 636-642
    CrossrefPubMedSearch in Google Scholar
  • 2 Brugge WR, Lauwers GY, Sahani D. et al. Cystic neoplasms of the pancreas. NEJM 2004; 351: 1218-1226
    CrossrefPubMedSearch in Google Scholar
  • 3 Allen PJ, D'Angelica M, Gonen M. et al. A selective approach to the resection of cystic lesions of the pancreas: results from 539 consecutive patients. Ann Surg 2006; 244: 572-582
    PubMedSearch in Google Scholar
  • 4 Elta GH, Enestvedt BK, Sauer BG. et al. ACG Clinical Guideline: Diagnosis and Management of Pancreatic Cysts. Am J Gastroenterol 2018; 113: 464-479
    CrossrefPubMedSearch in Google Scholar
  • 5 Oh HC, Seo DW, Kim SC. et al. Septated cystic tumors of the pancreas: is it possible to treat them by endoscopic ultrasonography-guided intervention?. Scand J Gastroenterol 2009; 44: 242-247
    CrossrefPubMedSearch in Google Scholar
  • 6 Barthet M, Giovannini M, Lesavre N. et al. Endoscopic ultrasound-guided radiofrequency ablation for pancreatic neuroendocrine tumors and pancreatic cystic neoplasms: a prospective multicenter study. Endoscopy 2019; 51: 836-842
    Thieme ConnectPubMedSearch in Google Scholar
  • 7 Pai M, Habib N, Senturk H. et al. Endoscopic ultrasound guided radiofrequency ablation, for pancreatic cystic neoplasms and neuroendocrine tumors. World J Gastrointest Surg 2015; 7: 52-59
    CrossrefPubMedSearch in Google Scholar
  • 8 Choi JH, Seo DW, Song TJ. et al. Endoscopic ultrasound-guided radiofrequency ablation for management of benign solid pancreatic tumors. Endoscopy 2018; 50: 1099-1104
    Thieme ConnectPubMedSearch in Google Scholar
  • 9 Eisenhauer EA, Therasse P, Bogaerts J. et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 2009; 45: 228-247
    CrossrefPubMedSearch in Google Scholar
  • 10 Choi JH, Lee SH, Choi YH. et al. Safety of endoscopic ultrasound-guided ethanol ablation for pancreatic cystic lesions: A single-center experience of 214 patients. Hepatobiliary Pancreat Dis Int 2019; 18: 562-568
    CrossrefPubMedSearch in Google Scholar
  • 11 Choi JH, Seo DW, Song TJ. et al. Long-term outcomes after endoscopic ultrasound-guided ablation of pancreatic cysts. Endoscopy 2017; 49: 866-873
    Thieme ConnectPubMedSearch in Google Scholar
  • 12 Oh HC, Seo DW, Song TJ. et al. Endoscopic ultrasonography-guided ethanol lavage with paclitaxel injection treats patients with pancreatic cysts. Gastroenterology 2011; 140: 172-179
    CrossrefPubMedSearch in Google Scholar