Leitlinie zur Langzeit-Sauerstofftherapie^[*]

Zusammenfassung

Die Langzeit-Sauerstofftherapie hat einen hohen Stellenwert sowohl zur Verminderung der Letalität als auch zur Verbesserung der Leistungsfähigkeit bei Patienten mit chronischen Lungenerkrankungen.

Die Grundvoraussetzung für die Langzeit-Sauerstofftherapie ist die adäquate Diagnostik und Indikationsstellung. Sinnvoll ist eine kausale Unterscheidung in eine chronische hypoxämische oder hyperkapnische respiratorische Insuffizienz, aus der sich die Differentialindikation zur nichtinvasiven Beatmung ergibt.

Die revidierte Leitlinie behandelt u. a. die Diagnostik und die Indikation bei chronischen Lungen- und Herzerkrankungen sowie den Einsatz in der Palliativmedizin und gibt eine detaillierte Beschreibung der verfügbaren Sauerstoffsysteme. Die Leitlinie soll dazu beitragen, die teilweise bestehende Unter-, Fehl- und Überversorgung zu vermeiden. Zudem wird im Kapitel „Postakute Sauerstofftherapie“ die im Alltag relevante, bisher nicht definierte Vorgehensweise für die Verschreibung einer Sauerstofftherapie am Ende eines stationären Aufenthaltes für den häuslichen Bereich diskutiert. Ein weiterer wichtiger Punkt, die korrekte Verordnung mobiler Sauerstoffsysteme, wird auch in der Leitlinie dargestellt. Die vorliegende aktualisierte Leitlinie zur Langzeit-Sauerstofftherapie löst die alte im Jahr 2008 publizierte Version ab.

Abstract

Long-term oxygen therapy is of great importance both for reducing mortality and for improving performance in patients with chronic lung diseases. The prerequisites for Long-term oxygen therapy are adequate diagnostics and clearly defined indication. A causal distinction into chronic hypoxaemic and hypercapnic respiratory failure is reasonable, from which the differential indication for non-invasive ventilation results.

The revised guideline covers the diagnostics and indication of chronic lung and heart diseases, the role of oxygen in terminal illness and gives a detailed description of available oxygen devices. The guideline is intended to help avoid undersupply, oversupply and false prescriptions. Furthermore, the chapter “Postacute Oxygen Therapy” discusses the procedure, relevant in everyday life, but not yet clearly defined, for prescribing oxygen therapy for the home at the end of an inpatient stay. Another important point, the correct prescription of mobile oxygen systems, is also presented in the guideline. This document is a revised version of the guideline for longterm oxygen therapy and replaces the version of 2008.

^* Verabschiedet von den Vorständen der beteiligten Fachgesellschaften am 27. 07. 2020.

Publication History

Article published online:
08 December 2020

• 16 Literatur

• 1 Magnussen H, Kirsten AM, Köhler D. et al. Guidelines for long-term oxygen therapy. German Society for Pneumology and Respiratory Medicine. Pneumologie 2008; 62: 748-756
• 2 www.awmf.org/leitlinien
• 3 Celli BR, MacNee W. ATS/ERS Task Force. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004; 23: 932-946
• 4 Nocturnal Oxygen Therapy Trial Group. Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Ann Intern Med 1980; 93: 391-398
• 5 Report of the Medical Research Council Working Party. Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Lancet 1981; 1: 681-686
• 6 Stoller JK, Panos RJ, Krachman S. et al. Oxygen therapy for patients with COPD: current evidence and the long-term oxygen treatment trial. Chest 2010; 138: 179-187
• 7 Windisch W, Dreher M, Geiseler J. et al. Guidelines for Non-Invasive and Invasive Home Mechanical Ventilation for Treatment of Chronic Respiratory Failure – Update 2017. Pneumologie 2017; 71: 722-795
• 8 Grassino A, Macklem PT. Respiratory muscle fatigue and ventilatory failure. Ann Rev Med 1984; 35: 625-647
• 9 Bégin P, Grassino A. Inspiratory muscle dysfunction and chronic hypercapnia in chronic obstructive pulmonary disease. Am Rev Respir Dis 1991; 143: 905-912
• 10 Vogelmeier C, Buhl R, Burghuber O. et al. Guideline for the Diagnosis and Treatment of COPD Patients – Issued by the German Respiratory Society and the German Atemwegsliga in Cooperation with the Austrian Society of Pneumology. Pneumologie 2018; 72: 253-308
• 11 Magnet FS, Schwarz SB, Callegari J. et al. Long-Term Oxygen Therapy: Comparison of the German and British Guidelines. Respiration 2017; 93: 253-263
• 12 Magnet FS, Storre JH, Windisch W. Home oxygen therapy: evidence versus reality. Expert Rev Respir Med 2017; 11: 425-441
• 13 Górecka D, Gorzelak K, Sliwiński P. et al. Effect of long-term oxygen therapy on survival in patients with chronic obstructive pulmonary disease with moderate hypoxaemia. Thorax 1997; 52: 674-679
• 14 Chaouat A, Weitzenblum E, Kessler R. et al. A randomized trial of nocturnal oxygen therapy in chronic obstructive pulmonary disease patients. Eur Respir J 1999; 14: 1002-1008
• 15 Ekström M, Ringbaek T. Which patients with moderate hypoxemia benefit from long-term oxygen therapy? Ways forward. Int J Chron Obstruct Pulmon Dis 2018; 13: 231-235
• 16 Hardinge M, Annandale J, Bourne S. et al. British Thoracic Society guidelines for home oxygen use in adults. Thorax 2015; 70: i1-43
• 17 Muñoz X, Torres F, Sampol G. et al. Accuracy and reliability of pulse oximetry at different arterial carbon dioxide pressure levels. Eur Respir J 2008; 32: 1053-1059
• 18 Roberts CM, Bugler JR, Melchor R. et al. Value of pulse oximetry in screening for long-term oxygen therapy requirement. Eur Respir J 1993; 6: 559-562
• 19 Carlin BW, Clausen JL, Ries AL. The use of cutaneous oximetry in the prescription of long-term oxygen therapy. Chest 1988; 94: 239-241
• 20 Zavorsky GS, Cao J, Mayo NE. et al. Arterial versus capillary blood gases: a meta-analysis. Respir Physiol Neurobiol 2007; 155: 268-279
• 21 Roberts CM, Franklin J, OʼNeill A. et al. Screening patients in general practice with COPD for long-term domiciliary oxygen requirement using pulse oximetry. Respir Med 1998; 92: 1265-1268
• 22 Eaton T, Rudkin S, Garrett JE. et al. The clinical utility of arterialized earlobe capillary blood in the assessment of patients for long-term oxygen therapy. Respir Med 2001; 95: 655-660
• 23 Ekkernkamp E, Welte L, Schmoor C. et al. Spot check analysis of gas exchange: invasive versus noninvasive methods. Respiration 2015; 89: 294-303
• 24 Pitkin AD, Roberts CM, Wedzicha JA. Arterialised earlobe blood gas analysis: an underused technique. Thorax 1994; 49: 364-366
• 25 Fajac I, Texereau J, Rivoal V. et al. Blood gas measurement during exercise: a comparative study between arterialized earlobe sampling and direct arterial puncture in adults. Eur Respir J 1998; 11: 712-715
• 26 Hughes JM. Blood gas estimations from arterialized capillary blood versus arterial puncture: are they different?. Eur Respir J 1996; 9: 184-185
• 27 Dar K, Williams T, Aitken R. et al. Arterial versus capillary sampling for analysing blood gas pressures. BMJ 1995; 310: 24-25
• 28 Sauty A, Uldry C, Debétaz LF. et al. Differences in PO₂ and PCO₂ between arterial and arterialized earlobe samples. Eur Respir J 1996; 9: 186-189
• 29 Magnet FS, Majorski DS, Callegari J. et al. Capillary PO does not adequately reflect arterial PO in hypoxemic COPD patients. Int J Chron Obstruct Pulmon Dis 2017; 12: 2647-2653
• 30 Diekmann M, Smidt U. Berechnung eines Standard-PaO₂ in Analogie zum Standard-Bikarbonat. Atemw Lungenkr 1984; 10: 248-260
• 31 Vergeret J, Brambilla C, Mounier L. Portable oxygen therapy: use and benefit in hypoxaemic COPD patients on long-term oxygen therapy. Eur Respir J 1989; 2: 20-25
• 32 McKeon JL, Murree-Allen K, Saunders NA. Supplemental oxygen and quality of sleep in patients with chronic obstructive lung disease. Thorax 1989; 44: 184-188
• 33 Fletcher EC, Donner CF, Midgren B. et al. Survival in COPD patients with a daytime PaO₂ greater than 60 mmHg with and without nocturnal oxyhemoglobin desaturation. Chest 1992; 101: 649-655
• 34 Fletcher EC, Luckett RA, Goodnight-White S. et al. A double-blind trial of nocturnal supplemental oxygen for sleep desaturation in patients with chronic obstructive pulmonary disease and a daytime PaO₂ above 60 mmHg. Am Rev Respir Dis 1992; 145: 1070-1076
• 35 Zinman R, Corey M, Coates AL. et al. Nocturnal home oxygen in the treatment of hypoxemic cystic fibrosis patients. J Pediatr 1989; 114: 368-377
• 36 Spier S, Rivlin J, Hughes D. et al. The effect of oxygen on sleep, blood gases, and ventilation in cystic fibrosis. Am Rev Respir Dis 1984; 129: 712-718
• 37 Gozal D. Nocturnal ventilatory support in patients with cystic fibrosis: comparison with supplemental oxygen. Eur Respir J 1997; 10: 1999-2003
• 38 Vázquez JC, Pérez-Padilla R. Effect of oxygen on sleep and breathing in patients with interstitial lung disease at moderate altitude. Respiration 2001; 68: 584-589
• 39 Krachman SL, Nugent T, Crocetti J. et al. Effects of oxygen therapy on left ventricular function in patients with Cheyne-Stokes respiration and congestive heart failure. J Clin Sleep Med 2005; 1: 271-276
• 40 Javaheri S, Ahmed M, Parker TJ. et al. Effects of nasal O₂ on sleep-related disordered breathing in ambulatory patients with stable heart failure. Sleep 1999; 22: 1101-1106
• 41 Hanly PJ, Millar TW, Steljes DG. et al. The effect of oxygen on respiration and sleep in patients with congestive heart failure. Ann Intern Med 1989; 111: 777-782
• 42 Staniforth AD, Kinnear WJ, Starling R. et al. Effect of oxygen on sleep quality, cognitive function and sympathetic activity in patients with chronic heart failure and Cheyne-Stokes respiration. Eur Heart J 1998; 19: 922-928
• 43 Andreas S, Clemens C, Sandholzer H. et al. Improvement of exercise capacity with treatment of Cheyne-Stokes respiration in patients with congestive heart failure. J Am Coll Cardiol 1996; 27: 1486-1490
• 44 Broström A, Hubbert L, Jakobsson P. et al. Effects of long-term nocturnal oxygen treatment in patients with severe heart failure. J Cardiovasc Nurs 2005; 20: 385-396
• 45 Paul B, Joseph M, De Pasquale CG. Domiciliary oxygen therapy improves sub-maximal exercise capacity and quality of life in chronic heart failure. Heart Lung Circ 2008; 17: 220-223
• 46 Ahmadi Z, Sundh J, Bornefalk-Hermansson A. et al. Long-Term Oxygen Therapy 24 vs 15 h/day and Mortality in Chronic Obstructive Pulmonary Disease. PloS one 2016; 11: e0163293
• 47 Sundh J, Ahmadi Z, Ekström M. Daily duration of long-term oxygen therapy and risk of hospitalization in oxygen-dependent COPD patients. Int J Chron Obstruct Pulmon Dis 2018; 13: 2623-2628
• 48 Magnussen H, Hauck RW, Worth H. et al. Statement to long term oxygen therapy. Pneumologie 2014; 68: 591-593
• 49 Singh D, Agusti A, Anzueto A. et al. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: the GOLD science committee report 2019. Eur Respir J 2019; 53: 1900164
• 50 Coleta KD, Silveira LV, Lima DF. et al. Predictors of first-year survival in patients with advanced COPD treated using long-term oxygen therapy. Respir Med 2008; 102: 512-518
• 51 Chambellan A, Chailleux E, Similowski T. Prognostic value of the hematocrit in patients with severe COPD receiving long-term oxygen therapy. Chest 2005; 128: 1201-1208
• 52 Albert RK, Au DH. Long-Term Oxygen Treatment Trial Research Group. et al. A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation. N Engl J Med 2016; 375: 1617-1627
• 53 Heaton RK, Grant I, McSweeny AJ. et al. Psychologic effects of continuous and nocturnal oxygen therapy in hypoxemic chronic obstructive pulmonary disease. Arch Intern Med 1983; 143: 1941-1947
• 54 Jacobs SS, Lederer DJ, Garvey CM. et al. Optimizing Home Oxygen Therapy. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc 2018; 15: 1369-1381
• 55 Moore RP, Berlowitz DJ, Denehy L. et al. A randomised trial of domiciliary, ambulatory oxygen in patients with COPD and dyspnoea but without resting hypoxaemia. Thorax 2011; 66: 32-37
• 56 Drummond MB, Blackford AL, Benditt JO. et al. Continuous oxygen use in nonhypoxemic emphysema patients identifies a high-risk subset of patients: retrospective analysis of the National Emphysema Treatment Trial. Chest 2008; 134: 497-506
• 57 Moy ML, Harrington KF, Sternberg AL. et al. Characteristics at the time of oxygen initiation associated with its adherence: Findings from the COPD Long-term Oxygen Treatment Trial. Respir Med 2019; 149: 52-58
• 58 Paneroni M, Ambrosino N, Simonelli C. et al. Physical Activity in Patients with Chronic Obstructive Pulmonary Disease on Long-Term Oxygen Therapy: A Cross-Sectional Study. Int J Chron Obstruct Pulmon Dis 2019; 14: 2815-2823
• 59 Casaburi R, Porszasz J, Hecht A. et al. Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapy. COPD 2012; 9: 3-11
• 60 Guyatt GH, McKim DA, Austin P. et al. Appropriateness of domiciliary oxygen delivery. Chest 2000; 118: 1303-1308
• 61 Douglas WW, Ryu JH, Schroeder DR. Idiopathic pulmonary fibrosis: Impact of oxygen and colchicine, prednisone, or no therapy on survival. Am J Respir Crit Care Med 2000; 161: 1172-1178
• 62 Tomioka H, Imanaka K, Hashimoto K. et al. Health-related quality of life in patients with idiopathic pulmonary fibrosis – cross-sectional and longitudinal study. Intern Med 2007; 46: 1533-1542
• 63 Swinburn CR, Mould H, Stone TN. et al. Symptomatic benefit of supplemental oxygen in hypoxemic patients with chronic lung disease. Am Rev Respir Dis 1991; 143: 913-915
• 64 Harris-Eze AO, Sridhar G, Clemens RE. et al. Oxygen improves maximal exercise performance in interstitial lung disease. Am J Respir Crit Care Med 1994; 150: 1616-1622
• 65 Visca D, Montgomery A, de Lauretis A. et al. Ambulatory oxygen in interstitial lung disease. Eur Respir J 2011; 38: 987-990
• 66 Frank RC, Hicks S, Duck AM. et al. Ambulatory oxygen in idiopathic pulmonary fibrosis: of what benefit?. Eur Respir J 2012; 40: 269-270
• 67 Sharp C, Adamali H, Millar AB. Ambulatory and short-burst oxygen for interstitial lung disease. Cochrane Database Syst Rev 2016; 7: CD011716
• 68 Bell EC, Cox NS, Goh N. et al. Oxygen therapy for interstitial lung disease: a systematic review. Eur Respir Rev 2017; 26(143): 160080
• 69 Visca D, Mori L, Tsipouri V. et al. Effect of ambulatory oxygen on quality of life for patients with fibrotic lung disease (AmbOx): a prospective, open-label, mixed-method, crossover randomised controlled trial. Lancet Respir Med 2018; 6: 759-770
• 70 Elphick HE, Mallory G. Oxygen therapy for cystic fibrosis. Cochrane Database Syst Rev 2013; 7: CD003884
• 71 Young AC, Wilson JW, Kotsimbos TC. et al. The impact of nocturnal oxygen desaturation on quality of life in cystic fibrosis. J Cyst Fibros 2011; 10: 100-106
• 72 Smith PE, Edwards RH, Calverley PM. Oxygen treatment of sleep hypoxaemia in Duchenne muscular dystrophy. Thorax 1989; 44: 997-1001
• 73 Leger P, Bedicam JM, Cornette A. et al. Nasal intermittent positive pressure ventilation. Long-term follow-up in patients with severe chronic respiratory insufficiency. Chest 1994; 105: 100-105
• 74 Simonds AK, Elliott MW. Outcome of domiciliary nasal intermittent positive pressure ventilation in restrictive and obstructive disorders. Thorax 1995; 50: 604-609
• 75 Buyse B, Meersseman W, Demedts M. Treatment of chronic respiratory failure in kyphoscoliosis: oxygen or ventilation?. Eur Respir J 2003; 22: 525-528
• 76 Gustafson T, Franklin KA, Midgren B. et al. Survival of patients with kyphoscoliosis receiving mechanical ventilation or oxygen at home. Chest 2006; 130: 1828-1833
• 77 Jäger L, Franklin KA, Midgren B. et al. Increased survival with mechanical ventilation in posttuberculosis patients with the combination of respiratory failure and chest wall deformity. Chest 2008; 133: 156-160
• 78 Rose L, McKim D, Leasa D. et al. Patterns of healthcare utilisation for respiratory complications of adults with neuromuscular disease: a population study. Eur Respir J 2018; 3: 52
• 79 Windisch W. Donʼt forget about neuromuscular disorders!. Eur Respir J 2018; 3: 52
• 80 Köhnlein T, Windisch W, Köhler D. et al. Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial. Lancet Respir Med 2014; 2: 698-705
• 81 Murphy PB, Rehal S, Arbane G. et al. Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation: A Randomized Clinical Trial. JAMA 2017; 317: 2177-2186
• 82 Dubois P, Jamart J, Machiels J. et al. Prognosis of severely hypoxemic patients receiving long-term oxygen therapy. Chest 1994; 105: 469-474
• 83 Riemann D, Baum E, Cohrs S. et al. S3-Leitlinie Nicht erholsamer Schlaf/Schlafstörungen. Somnologie 2017; 21: 2-44
• 84 Ponikowski P, Voors AA, Anker SD. et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 2016; 18: 891-975
• 85 Clark AL, Johnson M, Fairhurst C. et al. Does home oxygen therapy (HOT) in addition to standard care reduce disease severity and improve symptoms in people with chronic heart failure? A randomised trial of home oxygen therapy for patients with chronic heart failure. Health Technol Assess 2015; 19: 1-120
• 86 Arzt M, Woehrle H, Oldenburg O. et al. Prevalence and Predictors of Sleep-Disordered Breathing in Patients With Stable Chronic Heart Failure: The SchlaHF Registry. JACC Heart Fail 2016; 4: 116-125
• 87 Arzt M, Oldenburg O, Graml A. et al. Phenotyping of Sleep-Disordered Breathing in Patients With Chronic Heart Failure With Reduced Ejection Fraction-the SchlaHF Registry. J Am Heart Assoc 2017; 6(12): PMID:29187390
• 88 Mayer G, Arzt M, Braumann B. et al. German S3 Guideline Nonrestorative Sleep/Sleep Disorders, chapter “Sleep-Related Breathing Disorders in Adults,” short version: German Sleep Society (Deutsche Gesellschaft für Schlafforschung und Schlafmedizin, DGSM). Somnologie 2017; 21: 290-301
• 89 Andreas S, Bingeli C, Mohacsi P. et al. Nasal oxygen and muscle sympathetic nerve activity in heart failure. Chest 2003; 123: 366-371
• 90 Oldenburg O, Wellmann B, Buchholz A. et al. Nocturnal hypoxaemia is associated with increased mortality in stable heart failure patients. Eur Heart J 2016; 37: 1695-1703
• 91 Randerath W, Verbraecken J, Andreas S. et al. Definition, discrimination, diagnosis and treatment of central breathing disturbances during sleep. Eur Respir J 2017; 49: 1600959
• 92 Cowie MR, Woehrle H, Wegscheider K. et al. Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure. N Engl J Med 2015; 373: 1095-1105
• 93 Galiè N, Humbert M, Vachiery JL. et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Respir J 2015; 46: 903-975
• 94 Meyer FJ, Ewert R, Hoeper MM. et al. Peripheral airway obstruction in primary pulmonary hypertension. Thorax 2002; 57: 473-476
• 95 Sun XG, Hansen JE, Oudiz RJ. et al. Pulmonary function in primary pulmonary hypertension. J Am Coll Cardiol 2003; 41: 1028-1035
• 96 Hoeper MM, Pletz MW, Golpon H. et al. Prognostic value of blood gas analyses in patients with idiopathic pulmonary arterial hypertension. Eur Respir J 2007; 29: 944-950
• 97 Jilwan FN, Escourrou P, Garcia G. et al. High occurrence of hypoxemic sleep respiratory disorders in precapillary pulmonary hypertension and mechanisms. Chest 2013; 143: 47-55
• 98 Rafanan AL, Golish JA, Dinner DS. et al. Nocturnal hypoxemia is common in primary pulmonary hypertension. Chest 2001; 120: 894-899
• 99 Hoeper MM, Vonk-Noordegraaf A. Is there a vanishing pulmonary capillary syndrome?. Lancet Respir Med 2017; 5: 676-678
• 100 Ulrich S, Keusch S, Hildenbrand FF. et al. Effect of nocturnal oxygen and acetazolamide on exercise performance in patients with pre-capillary pulmonary hypertension and sleep-disturbed breathing: randomized, double-blind, cross-over trial. Eur Heart J 2015; 36: 615-623
• 101 Ulrich S, Hasler ED, Saxer S. et al. Effect of breathing oxygen-enriched air on exercise performance in patients with precapillary pulmonary hypertension: randomized, sham-controlled cross-over trial. Eur Heart J 2017; 38: 1159-1168
• 102 Grünig E, Benjamin N, Krüger U. et al. General and supportive therapy of pulmonary arterial hypertension. Dtsch Med Wochenschr 2016; 141: S26-S32
• 103 Grünig E, Benjamin N, Krüger U. et al. General measures and supportive therapy for pulmonary arterial hypertension: Updated recommendations from the Cologne Consensus Conference 2018. Int J Cardiol 2018; 272S: 30-36
• 104 Sandoval J, Aguirre JS, Pulido T. et al. Nocturnal oxygen therapy in patients with the Eisenmenger syndrome. Am J Respir Crit Care Med 2001; 164: 1682-1687
• 105 Bradley JM, Lasserson T, Elborn S. et al. A systematic review of randomized controlled trials examining the short-term benefit of ambulatory oxygen in COPD. Chest 2007; 131: 278-285
• 106 Uronis HE, Ekström MP, Currow DC. et al. Oxygen for relief of dyspnoea in people with chronic obstructive pulmonary disease who would not qualify for home oxygen: a systematic review and meta-analysis. Thorax 2015; 70: 492-494
• 107 Ameer F, Carson KV, Usmani ZA. et al. Ambulatory oxygen for people with chronic obstructive pulmonary disease who are not hypoxaemic at rest. Cochrane Database Syst Rev 2014; 6: CD000238
• 108 Ekström M, Ahmadi Z, Bornefalk-Hermansson A. et al. Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy. Cochrane Database Syst Rev 2016; 11: CD006429
• 109 Jindal SK. Long term oxygen therapy-it is still relevant?. J Thorac Dis 2017; 9: E266-E268
• 110 Nonoyama ML, Brooks D, Guyatt GH. et al. Effect of oxygen on health quality of life in patients with chronic obstructive pulmonary disease with transient exertional hypoxemia. Am J Respir Crit Care Med 2007; 176: 343-349
• 111 Sandland CJ, Morgan MD, Singh SJ. Patterns of domestic activity and ambulatory oxygen usage in COPD. Chest 2008; 134: 753-760
• 112 Ringbaek T, Martinez G, Lange P. The long-term effect of ambulatory oxygen in normoxaemic COPD patients: a randomised study. Chron Respir Dis 2013; 10: 77-84
• 113 Héraud N, Préfaut C, Durand F. et al. A Does correction of exercise-induced desaturation by O(2) always improve exercise tolerance in COPD? A preliminary study. Respir Med 2008; 102: 1276-1286
• 114 Lacasse Y, Lecours R, Pelletier C. et al. Randomised trial of ambulatory oxygen in oxygen-dependent COPD. Eur Respir J 2005; 25: 1032-1038
• 115 Eaton T, Garrett JE, Young P. et al. Ambulatory oxygen improves quality of life of COPD patients: a randomised controlled study. Eur Respir J 2002; 20: 306-312
• 116 McDonald CF, Blyth CM, Lazarus MD. et al. Exertional oxygen of limited benefit in patients with chronic obstructive pulmonary disease and mild hypoxemia. Am J Respir Crit Care Med 1995; 152: 1616-1619
• 117 Hardinge M, Suntharalingam J, Wilkinson T. Guideline update: The British Thoracic Society Guidelines on home oxygen use in adults. Thorax 2015; 70: 589-591
• 118 Arnold E, Bruton A, Donovan-Hall M. et al. Ambulatory oxygen: why do COPD patients not use their portable systems as prescribed? A qualitative study. BMC Pulm Med 2011; 11: 9
• 119 Beasley R, Chien J, Douglas J. et al. Target oxygen saturation range: 92–96 % versus 94–98. Respirology 2017; 22: 200-202
• 120 Crisafulli E, Costi S, De Blasio F. et al. Effects of a walking aid in COPD patients receiving oxygen therapy. Chest 2007; 131: 1068-1074
• 121 Katsenos S, Constantopoulos SH. Long-Term Oxygen Therapy in COPD: Factors Affecting and Ways of Improving Patient Compliance. Pulm Med 2011; 2011: 325-362
• 122 Casanova C, Cote C, Marin JM. et al. Distance and oxygen desaturation during the 6-min walk test as predictors of long-term mortality in patients with COPD. Chest 2008; 134: 746-752
• 123 Somfay A, Porszasz J, Lee SM. et al. Dose-response effect of oxygen on hyperinflation and exercise endurance in nonhypoxaemic COPD patients. Eur Respir J 2001; 18: 77-84
• 124 Jarosch I, Gloeckl R, Damm E. et al. Short-term Effects of Supplemental Oxygen on 6-Min Walk Test Outcomes in Patients With COPD: A Randomized, Placebo-Controlled, Single-blind, Crossover Trial. Chest 2017; 151: 795-803
• 125 Dyer F, Callaghan J, Cheema K. et al. Ambulatory oxygen improves the effectiveness of pulmonary rehabilitation in selected patients with chronic obstructive pulmonary disease. Chron Respir Dis 2012; 9: 83-91
• 126 Alison JA, McKeough ZJ, Leung RWM. et al. Oxygen compared to air during exercise training in COPD with exercise-induced desaturation. Eur Respir J 2019; 53: 1802429
• 127 Emtner M, Porszasz J, Burns M. et al. Benefits of supplemental oxygen in exercise training in nonhypoxemic chronic obstructive pulmonary disease patients. Am J Respir Crit Care Med 2003; 168: 1034-1042
• 128 Spielmanns M, Fuchs-Bergsma C, Winkler A. et al. Effects of Oxygen Supply During Training on Subjects With COPD Who Are Normoxemic at Rest and During Exercise: A Blinded Randomized Controlled Trial. Respir Care 2015; 60: 540-548
• 129 Neunhäuserer D, Steidle-Kloc E, Weiss G. Supplemental Oxygen During High-Intensity Exercise Training in Nonhypoxemic Chronic Obstructive Pulmonary Disease. Am J Med 2016; 129: 1185-1193
• 130 Frat JP, Thille AW, Mercat A. et al. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 2015; 372: 2185-2196
• 131 Spoletini G, Alotaibi M, Blasi F. et al. Heated Humidified High-Flow Nasal Oxygen in Adults: Mechanisms of Action and Clinical Implications. Chest 2015; 148: 253-261
• 132 Nishimura M. High-Flow Nasal Cannula Oxygen Therapy in Adults: Physiological Benefits, Indication, Clinical Benefits, and Adverse Effects. Respir Care 2016; 61: 529-541
• 133 Pisani L, Fasano L, Corcione N. et al. Change in pulmonary mechanics and the effect on breathing pattern of high flow oxygen therapy in stable hypercapnic COPD. Thorax 2017; 72: 373-375
• 134 Nielsen KR, Ellington LE, Gray AJ. et al. Effect of High-Flow Nasal Cannula on Expiratory Pressure and Ventilation in Infant, Pediatric, and Adult Models. Respir Care 2018; 63: 147-157
• 135 Mauri T, Galazzi A, Binda F. et al. Impact of flow and temperature on patient comfort during respiratory support by high-flow nasal cannula. Crit Care 2018; 22: 120
• 136 Storgaard LH, Hockey HU, Laursen BS. et al. Long-term effects of oxygen-enriched high-flow nasal cannula treatment in COPD patients with chronic hypoxemic respiratory failure. Int J Chron Obstruct Pulmon Dis 2018; 13: 1195-1205
• 137 Bräunlich J, Seyfarth HJ, Wirtz H. Nasal High-flow versus non-invasive ventilation in stable hypercapnic COPD: a preliminary report. Multidiscip Respir Med 2015; 10: 27
• 138 Bräunlich J, Dellweg D, Bastian A. et al. Nasal high-flow versus noninvasive ventilation in patients with chronic hypercapnic COPD. Int J Chron Obstruct Pulmon Dis 2019; 14: 1411-1421
• 139 Booth S, Wade R, Johnson M. et al. The use of oxygen in the palliation of breathlessness. A report of the expert working group of the Scientific Committee of the Association of Palliative Medicine. Respir Med 2004; 98: 66-77
• 140 Ripamonti C, Bruera E. Dyspnea: pathophysiology and assessment. J Pain Symptom Manage 1997; 13: 220-232
• 141 Deutsche Krebsgesellschaft, Deutsche Krebshilfe, AWMF. Palliativmedizin für Patienten mit einer nicht-heilbaren Krebserkrankung, Langversion 2.1, 2020, AWMF-Registernummer: 128/001OL. https://www.leitlinienprogramm-onkologie.de/leitlinien/palliativmedizin/
• 142 OʼDriscoll BR, Neill J, Pulakal S. et al. A crossover study of short burst oxygen therapy (SBOT) for the relief of exercise-induced breathlessness in severe COPD. BMC Pulm Med 2011; 11: 23
• 143 Abernethy AP, McDonald CF, Frith PA. et al. Effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea: a double-blind, randomised controlled trial. Lancet 2010; 376: 784-793
• 144 Clemens KE, Quednau I, Klaschik E. Use of oxygen and opioids in the palliation of dyspnoea in hypoxic and non-hypoxic palliative care patients: a prospective study. Support Care Cancer 2009; 17: 367-377
• 145 Currow DC, Agar M, Smith J. et al. Does palliative home oxygen improve dyspnoea? A consecutive cohort study. Palliat Med 2009; 23: 309-316
• 146 Philip J, Gold M, Milner A. et al. A randomized, double-blind, crossover trial of the effect of oxygen on dyspnea in patients with advanced cancer. J Pain Symptom Manage 2006; 32: 541-550
• 147 Uronis HE, Currow DC, McCrory DC. et al. Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis. Br J Cancer 2008; 98: 294-299
• 148 Stevenson NJ, Calverley PM. Effect of oxygen on recovery from maximal exercise in patients with chronic obstructive pulmonary disease. Thorax 2004; 59: 668-672
• 149 Lewis CA, Eaton TE, Young P. et al. Short-burst oxygen immediately before and after exercise is ineffective in nonhypoxic COPD patients. Eur Respir J 2003; 22: 584-588
• 150 Garrod R, Paul EA, Wedzicha JA. Supplemental oxygen during pulmonary rehabilitation in patients with COPD with exercise hypoxaemia. Thorax 2000; 55: 539-543
• 151 Rooyackers JM, Dekhuijzen PN, Van Herwaarden CL. et al. Training with supplemental oxygen in patients with COPD and hypoxaemia at peak exercise. Eur Respir J 1997; 10: 1278-1284
• 152 Davidson PM, Johnson MJ. Update on the role of palliative oxygen. Curr Opin Support Palliat Care 2011; 5: 87-91
• 153 Galbraith S, Fagan P, Perkins P. et al. Does the use of a handheld fan improve chronic dyspnea? A randomized, controlled, crossover trial. J Pain Symptom Manage 2010; 39: 831-838
• 154 Corner J, Plant H, AʼHern R. et al. Non-pharmacological intervention for breathlessness in lung cancer. Palliat Med 1996; 10: 299-305
• 155 Filshie J, Penn K, Ashley S. et al. Acupuncture for the relief of cancer-related breathlessness. Palliat Med 1996; 10: 145-150
• 156 Leitlinien der DGP Sektion Pflege. Atemnot in der letzten Lebensphase. http://www.dgpalliativmedizin.de/pflege/pflegeleitlinien
• 157 Katsenos S, Charisis A, Daskalopoulos G. Long-term oxygen therapy in chronic obstructive pulmonary disease: the use of concentrators and liquid oxygen systems in north-western Greece. Respiration 2006; 73: 777-782
• 158 McCoy RW. Options for home oxygen therapy equipment: storage and metering of oxygen in the home. Respir Care 2013; 58: 65-85
• 159 Gould GA, Scott W, Hayhurst MD. et al. Technical and clinical assessment of oxygen concentrators. Thorax 1985; 40: 811-816
• 160 Aguiar C, Davidson J, Carvalho AK. et al. Tubing length for long-term oxygen therapy. Respir Care 2015; 60: 179-182
• 161 Kampelmacher MJ. Long-term oxygen therapy (LTOT) revisited: in defense of traditional LTOT systems. Rev Port Pneumol 2012; 18: 158-159
• 162 Pesce LI, Bassi GN, Santovito A. Clinical usefulness of a new portable oxygen concentrator. Monaldi Arch Chest Dis 1994; 49: 444-446
• 163 Burioka N, Takano K, Hoshino E. et al. Clinical utility of a newly developed pressure swing adsorption-type oxygen concentrator with a membrane humidifier. Respiration 1997; 64: 268-272
• 164 Hall LW, Kellagher RE, Fleet KJ. A portable oxygen generator. Anaesthesia 1986; 41: 516-518
• 165 Johns DP, Rochford PD, Streeton JA. Evaluation of six oxygen concentrators. Thorax 1985; 40: 806-810
• 166 www.sauerstoffliga.de
• 167 Melani AS, Sestini P, Rottoli P. Home oxygen therapy: re-thinking the role of devices. Expert Rev Clin Pharmacol 2018; 11: 279-289
• 168 Lee GJ, Oh YM, Oh SK. et al. Synchronization of oxygen delivery with breathing pattern for enhanced comfort: a bench study. Respir Care 2013; 58: 498-506
• 169 Chen JZ, Katz IM, Pichelin M. et al. Comparison of pulsed versus continuous oxygen delivery using realistic adult nasal airway replicas. Int J Chron Obstruct Pulmon Dis 2017; 12: 2559-2571
• 170 Palwai A, Skowronski M, Coreno A. et al. Critical comparisons of the clinical performance of oxygen-conserving devices. Am J Respir Crit Care Med 2010; 181: 1061-1071
• 171 Nasilowski J, Przybylowski T, Zielinski J. et al. Comparing supplementary oxygen benefits from a portable oxygen concentrator and a liquid oxygen portable device during a walk test in COPD patients on long-term oxygen therapy. Respir Med 2008; 102: 1021-1025
• 172 Mussa CC, Tonyan L, Chen YF. et al. Perceived Satisfaction With Long-Term Oxygen Delivery Devices Affects Perceived Mobility and Quality of Life of Oxygen-Dependent Individuals With COPD. Respir Care 2018; 63: 11-19
• 173 AlMutairi HJ, Mussa CC, Lambert CT. et al. Perspectives from COPD Subjects on Portable Long-Term Oxygen Therapy Devices. Respir Care 2018; 63: 1321-1330
• 174 Gloeckl R, Osadnik C, Bies L. et al. Comparison of continuous flow versus demand oxygen delivery systems in patients with COPD: A systematic review and meta-analysis. Respirology 2019; 24: 329-337
• 175 Gloeckl R, Jarosch I, Schneeberger T. et al. Comparison of supplemental oxygen delivery by continuous versus demand based flow systems in hypoxemic COPD patients – A randomized, single-blinded cross-over study. Respir Med 2019; 156: 26-32
• 176 Khor YH, McDonald CF, Hazard A. et al. Portable oxygen concentrators versus oxygen cylinder during walking in interstitial lung disease: A randomized crossover trial. Respirology 2017; 22: 1598-1603
• 177 Franchini ML, Athanazio R, Amato-Lourenço LF. et al. Oxygen With Cold Bubble Humidification Is No Better Than Dry Oxygen in Preventing Mucus Dehydration, Decreased Mucociliary Clearance, and Decline in Pulmonary Function. Chest 2016; 150: 407-414
• 178 Tausendpfund C, Petro W. Long-term oxygen therapy: which form of administration can be recommended?. Pneumologie 1996; 50: 260-267
• 179 Köhler D, Knoch M, Sommerfeld C. et al. A new oxygen applicator for simultaneous mouth and nose breathing. Chest 1993; 103: 1157-1160
• 180 Christopher KL, Schwartz MD. Transtracheal oxygen therapy. Chest 2011; 139: 435-440
• 181 Kampelmacher MJ, Deenstra M, van Kesteren RG. et al. Transtracheal oxygen therapy: an effective and safe alternative to nasal oxygen administration. Eur Respir J 1997; 10: 828-833
• 182 Roberts CM, Bell J, Wedzicha JA. Comparison of the efficacy of a demand oxygen delivery system with continuous low flow oxygen in subjects with stable COPD and severe oxygen desaturation on walking. Thorax 1996; 51: 831-834
• 183 Martí S, Pajares V, Morante F. et al. Are oxygen-conserving devices effective for correcting exercise hypoxemia?. Respir Care 2013; 58: 1606-1613
• 184 Chatburn RL, Lewarski JS, McCoy RW. Nocturnal oxygenation using a pulsed-dose oxygen-conserving device compared to continuous flow. Respir Care 2006; 51: 252-256
• 185 OʼDriscoll BR, Howard LS, Davison AG. BTS guideline for emergency oxygen use in adult patients. Thorax 2008; 63: vi1-68
• 186 Leggett RJ, Flenley DC. Portable oxygen and exercise tolerance in patients with chronic hypoxic cor pulmonale. Br Med J 1977; 2: 84-86
• 187 Peckham DG, McGibbon K, Tonkinson J. et al. Improvement in patient compliance with long-term oxygen therapy following formal assessment with training. Respir Med 1998; 92: 1203-1206
• 188 Pépin JL, Barjhoux CE, Deschaux C. ANTADIR Working Group on Oxygen Therapy. Association Nationale de Traitement à Domicile des Insuffisants Respiratories. et al. Long-term oxygen therapy at home. Compliance with medical prescription and effective use of therapy. Chest 1996; 109: 1144-1150
• 189 Lacasse Y, LaForge J, Maltais F. Got a match? Home oxygen therapy in current smokers. Thorax 2006; 61: 374-375
• 190 Andreas S, Batra A, Behr J. et al. Smoking cessation in patients with COPD. Pneumologie 2014; 68: 237-258
• 191 Amani H, Lozano DD, Blome-Eberwein S. Brother, have you got a light? Assessing the need for intubation in patients sustaining burn injury secondary to home oxygen therapy. J Burn Care Res 2012; 33: e280-e285
• 192 Galligan CJ, Markkanen PK, Fantasia LM. et al. A growing fire hazard concern in communities: home oxygen therapy and continued smoking habits. New Solut 2015; 24: 535-554
• 193 Tanash HA, Huss F, Ekström M. The risk of burn injury during long-term oxygen therapy: a 17-year longitudinal national study in Sweden. Int J Chron Obstruct Pulmon Dis 2015; 10: 2479-2484
• 194 Tanash HA, Ringbaek T, Huss F. et al. Burn injury during long-term oxygen therapy in Denmark and Sweden: the potential role of smoking. Int J Chron Obstruct Pulmon Dis 2017; 12: 193-197
• 195 www.europeanlung.org
• 196 www.melonet.de
• 197 Shrikrishna D, Coker RK. Managing passengers with stable respiratory disease planning air travel: British Thoracic Society recommendations. Thorax 2011; 66: 831-833
• 198 Dillard TA, Berg BW, Rajagopal KR. et al. Hypoxemia during air travel in patients with chronic obstructive pulmonary disease. Ann Intern Med 1989; 111: 362-367
• 199 www.g-ba.de