The Effect of Asthma Severity on Perinatal Outcomes: A Tertiary
                    Hospital Experience

Atakan Tanacan; Erdem Fadiloglu; Ebru Damadoglu Celebioglu; Nazli Orhan; Canan Unal; Tolga Celik; Ali Fuat Kalyoncu; Mehmet Sinan Beksac

doi:10.1055/a-1264-8207

Zeitschrift für Geburtshilfe und Neonatologie, Table of Contents

Z Geburtshilfe Neonatol 2021; 225(04): 333-340
DOI: 10.1055/a-1264-8207

Original Article

The Effect of Asthma Severity on Perinatal Outcomes: A Tertiary Hospital Experience

Authors

Atakan Tanacan

¹Department of Obstetric and Gynecology, Division of Perinatology, Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey
Erdem Fadiloglu

¹Department of Obstetric and Gynecology, Division of Perinatology, Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey
Ebru Damadoglu Celebioglu

²Division of Allergic and Immunological Diseases, Department of Chest Disease, Hacettepe Universitesi Tip Fakultesi, Ankara
Nazli Orhan

¹Department of Obstetric and Gynecology, Division of Perinatology, Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey
Canan Unal

¹Department of Obstetric and Gynecology, Division of Perinatology, Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey
Tolga Celik

³Division of Neonatology, Department of Pediatrics, Hacettepe Universitesi Tip Fakultesi, Ankara
Ali Fuat Kalyoncu

²Division of Allergic and Immunological Diseases, Department of Chest Disease, Hacettepe Universitesi Tip Fakultesi, Ankara
Mehmet Sinan Beksac

¹Department of Obstetric and Gynecology, Division of Perinatology, Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey

Abstract

Objective To evaluate the effect of asthma severity and disease exacerbation on pregnancy outcomes.

Materials and Methods Pregnancies were classified into 3 groups as mild (n=195), moderate (n=63), and severe (n=26) according to preconceptional asthma severity. Demographic features, clinical characteristics, and perinatal outcomes were compared between the groups. Delivery characteristics and pregnancy outcomes were also compared between the pregnancies with or without asthma exacerbation (43 and 241 pregnancies, respectively).

Results Worsening of symptoms during pregnancy was higher in moderate and severe asthma groups (p<0.001). Rates of spontaneous abortion, fetal structural anomaly, preterm delivery, preeclampsia, fetal growth restriction (FGR), oligohydramnios, gestational diabetes, and intrauterine fetal demise were higher in moderate and severe asthma groups (p-values were < 0.001, 0.01, 0.008, 0.02, 0.01, < 0.001, < 0.001, and 0.007, respectively). Admissions to neonatal intensive care units and neonatal complication rates were higher among moderate and severe asthma groups (p=0.035 and < 0.001). Spontaneous abortion, preterm delivery, preeclampsia, FGR, oligohydramnios, and neonatal complication rates were higher (p<0.001) in the group with exacerbated symptoms.

Conclusion Moderate to severe asthma before pregnancy and the exacerbation of asthma symptoms during pregnancy may lead to increased rates of perinatal complications.

Key words

antenatal care - high risk pregnancy - maternal risks - perinatal

Full Text

References

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