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Z Geburtshilfe Neonatol 2021; 225(04): 333-340
DOI: 10.1055/a-1264-8207
Original Article

The Effect of Asthma Severity on Perinatal Outcomes: A Tertiary Hospital Experience

Atakan Tanacan 
1   Department of Obstetric and Gynecology, Division of Perinatology, Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey
,
Erdem Fadiloglu 
1   Department of Obstetric and Gynecology, Division of Perinatology, Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey
,
Ebru Damadoglu Celebioglu
2   Division of Allergic and Immunological Diseases, Department of Chest Disease, Hacettepe Universitesi Tip Fakultesi, Ankara
,
Nazli Orhan
1   Department of Obstetric and Gynecology, Division of Perinatology, Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey
,
Canan Unal
1   Department of Obstetric and Gynecology, Division of Perinatology, Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey
,
Tolga Celik
3   Division of Neonatology, Department of Pediatrics, Hacettepe Universitesi Tip Fakultesi, Ankara
,
Ali Fuat Kalyoncu
2   Division of Allergic and Immunological Diseases, Department of Chest Disease, Hacettepe Universitesi Tip Fakultesi, Ankara
,
Mehmet Sinan Beksac
1   Department of Obstetric and Gynecology, Division of Perinatology, Hacettepe Universitesi Tip Fakultesi, Ankara, Turkey
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Abstract

Objective To evaluate the effect of asthma severity and disease exacerbation on pregnancy outcomes.

Materials and Methods Pregnancies were classified into 3 groups as mild (n=195), moderate (n=63), and severe (n=26) according to preconceptional asthma severity. Demographic features, clinical characteristics, and perinatal outcomes were compared between the groups. Delivery characteristics and pregnancy outcomes were also compared between the pregnancies with or without asthma exacerbation (43 and 241 pregnancies, respectively).

Results Worsening of symptoms during pregnancy was higher in moderate and severe asthma groups (p<0.001). Rates of spontaneous abortion, fetal structural anomaly, preterm delivery, preeclampsia, fetal growth restriction (FGR), oligohydramnios, gestational diabetes, and intrauterine fetal demise were higher in moderate and severe asthma groups (p-values were < 0.001, 0.01, 0.008, 0.02, 0.01, < 0.001, < 0.001, and 0.007, respectively). Admissions to neonatal intensive care units and neonatal complication rates were higher among moderate and severe asthma groups (p=0.035 and < 0.001). Spontaneous abortion, preterm delivery, preeclampsia, FGR, oligohydramnios, and neonatal complication rates were higher (p<0.001) in the group with exacerbated symptoms.

Conclusion Moderate to severe asthma before pregnancy and the exacerbation of asthma symptoms during pregnancy may lead to increased rates of perinatal complications.

Key words

antenatal care - high risk pregnancy - maternal risks - perinatal


Publication History

Received: 24 April 2020

Accepted after revision: 05 September 2020

Article published online:
14 October 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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