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Klin Monbl Augenheilkd 2020; 237(12): 1466-1467
DOI: 10.1055/a-1265-7105
Der interessante Fall

Interstitial Keratitis with Lipid Keratopathy Mimicking Corneal Opacity Induced by Brimonidine Tartrate Eye Drops

Interstitielle Keratitis mit Lipidkeratopathie ähnlich wie Hornhauttrübung mit Nebenwirkungen von Brimonidine-tartrate-Augentropfen
Yuka Kasuya
Ophthalmology, Jichi Medical University, Shimotsuke, Japan
,
Ichiya Sano
Ophthalmology, Jichi Medical University, Shimotsuke, Japan
,
Shinji Makino
Ophthalmology, Jichi Medical University, Shimotsuke, Japan
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Introduction

Lipid keratopathy can result from corneal sterile infiltration with neovascularization, and can be secondary to stromal corneal herpes, other corneal diseases, trauma, contact lens wear, or systemic diseases [1], [2], [3], [4], [5].

In 2017, Maruyama et al. [6] reported two cases of peripheral corneal opacity that developed after treatment with brimonidine tartrate (BT). BT ophthalmic solution, a topical α2-adrenoreceptor agonist, has been used for glaucoma therapy. To date, four reports including eight cases with corneal opacity induced by BT use have been described in Japan [6], [7], [8], [9].

Here, we present a case of a 77-year-old woman with unilateral lipid keratopathy mimicking corneal opacity induced by BT.



Publikationsverlauf

Eingereicht: 21. März 2020

Angenommen: 07. September 2020

Artikel online veröffentlicht:
07. Dezember 2020

© 2020. Thieme. All rights reserved.

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  • References

  • 1 Alfonso E, Arrellanes L, Boruchoff SA. et al. Idiopathic bilateral lipid keratopathy. Br J Ophthalmol 1988; 72: 338-343
    CrossrefPubMedSuche in Google Scholar
  • 2 Barchiesi BJ, Eckel RH, Ellis PP. The cornea and disorders of lipid metabolism. Surv Ophthalmol 1991; 36: 1-22
    CrossrefPubMedSuche in Google Scholar
  • 3 Sharif Z, Sharif W. Corneal neovascularization: updates on pathophysiology, investigations & management. Rom J Ophthalmol 2019; 63: 15-22
    CrossrefPubMedSuche in Google Scholar
  • 4 Chu HS, Hu FR, Yang CM. et al. Subconjunctival injection of bevacizumab in the treatment of corneal neovascularization associated with lipid deposition. Cornea 2011; 30: 60-66
    CrossrefPubMedSuche in Google Scholar
  • 5 Pang Y, Zhang Q, Bao Y. A CARE-compliant article: ipsilateral progressive idiopathic lipid keratopathy: A case report. Medicine (Baltimore) 2019; 98: e16589
    CrossrefPubMedSuche in Google Scholar
  • 6 Maruyama Y, Ikeda Y, Yokoi N. et al. Severe corneal disorders developed after brimonidine tartrate ophthalmic solution use. Cornea 2017; 36: 1567-1569
    CrossrefPubMedSuche in Google Scholar
  • 7 Tsujinaka A, Takai Y, Inoue Y. et al. A case of bilateral deep stromal corneal opacity and vascularization after use of multiple antiglaucoma medications including brimonidine tartrate ophthalmic solution. Acta Ophthalmol 2019; 97: e948-e949
    CrossrefPubMedSuche in Google Scholar
  • 8 Manabe Y, Sawada A, Mochizuki K. Corneal sterile infiltration induced by topical use of ocular hypotensive agent. Eur J Ophthalmol 2019;
    CrossrefPubMedSuche in Google Scholar
  • 9 Yorifuji A, Hosotani Y, Okamoto M. et al. Three cases of corneal disorders developed after brimonidine tartrate ophthalmic solution use. Ganka 2019; 61: 1527-1533
    PubMedSuche in Google Scholar