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manuelletherapie 2020; 24(05): 217-222
DOI: 10.1055/a-1266-4454
Schwerpunkt
Einführung

CRPS – ein Syndrom mit Forschungsbedarf

Kathrin Allgöwer
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Zusammenfassung

Mit den Budapester Diagnosekriterien ist zwar ein klares Diagnosewerkzeug für das komplexe regionale Schmerzsyndrom (CRPS) vorgegeben, aber welche Therapie welchen Patienten tatsächlich hilft, ist immer noch nicht vollständig erforscht. Wichtig scheint in jedem Fall zu sein, interdisziplinär zusammenzuarbeiten, um den Betroffenen die beste Therapie zu bieten.



Publication History

Article published online:
16 December 2020

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  • Literatur

  • 1 Mitchell SW, Morehouse GR, Keen WW. Gunshot wounds and other injuries of nerves. Philadelphia: Lippincott & Co; 1864
    Search in Google Scholar
  • 2 Sudeck P. Über die acute (trophoneurotische) Knochenatrophie nach Entzündungen und Traumen der Extremitäten. Dtsch Med Wschr 1902; 28: 336-338
    Thieme ConnectPubMedSearch in Google Scholar
  • 3 Stanton-Hicks MD, Jänig W, Hassenbusch SJ. et al. Reflex sympathetic dystrophy: changing concepts and taxonomy. Pain 1995; 63: 127-133 doi:10.1016/0304–3959(95)00110-e
    CrossrefPubMedSearch in Google Scholar
  • 4 Mainka T, Bischoff FS, Baron R. et al. Comparison of muscle and joint pressure-pain thresholds in patients with complex regional pain syndrome and upper limb pain of other origin. Pain 2014; 155: 591-597 doi:10.1016/j.pain.2013.12.014
    CrossrefPubMedSearch in Google Scholar
  • 5 Gierthmühlen J, Maier C, Baron R. et al. Sensory signs in complex regional pain syndrome and peripheral nerve injury. Pain 2012; 153: 765-774 doi:10.1016/j.pain.2011.11.009
    CrossrefPubMedSearch in Google Scholar
  • 6 Reinersmann A, Landwehrt J, Krumova EK. et al. Impaired spatial body representation in complex regional pain syndrome type 1 (CRPS I). Pain 2012; 153: 2174-2181 doi:10.1016/j.pain.2012.05.025
    CrossrefPubMedSearch in Google Scholar
  • 7 Kolb L, Lang C, Seifert F. et al. Cognitive correlates of “neglect-like syndrome” in patients with complex regional pain syndrome. Pain 2012; 153: 1063-1073 doi:10.1016/j.pain.2012.02.014
    CrossrefPubMedSearch in Google Scholar
  • 8 Harden RN, Bruehl S, Perez RSGM. et al. Development of a severity score for CRPS. Pain 2010; 151: 870-876 doi:10.1016/j.pain.2010.09.031
    CrossrefPubMedSearch in Google Scholar
  • 9 Birklein F, Riedl B, Claus D. et al. Pattern of autonomic dysfunction in time course of complex regional pain syndrome. Clin Auton Res 1998; 8: 79-85 doi:10.1007/BF02267817
    CrossrefPubMedSearch in Google Scholar
  • 10 Marinus J, Moseley GL, Birklein F. et al. Clinical features and pathophysiology of complex regional pain syndrome. Lancet Neurol 2011; 10: 637-648 doi:10.1016/S1474–4422(11)70106–5
    CrossrefPubMedSearch in Google Scholar
  • 11 Birklein F, Riedl B, Sieweke N. et al. Neurological findings in complex regional pain syndromes – analysis of 145 cases. Acta neurologica Scandinavica 2000; 101: 262-269 doi:10.1034/j.1600–0404.2000.101004262x./
    CrossrefPubMedSearch in Google Scholar
  • 12 Birklein F. Leitlinien für Diagnostik und Therapie in der Neurologie. Diagnostik und Therapie komplexer regionaler Schmerzsyndrome (CRPS) (08. Januar 2018). AWMF-Registernummer: 030/116. https://www.awmf.org/leitlinien/detail/ll/030–116.html Stand: 30.07.2020
    PubMed
  • 13 Stanton-Hicks M, Jänig W, Hassenbusch S. et al. Reflex sympathetic dystrophy. Changing concepts and taxonomy. Pain 1995; 63: 127-133 doi:10.1016/0304–3959(95)00110-e
    CrossrefPubMedSearch in Google Scholar
  • 14 Bruehl S, Maihöfner C, Stanton-Hicks M. et al. Complex regional pain syndrome. Evidence for warm and cold subtypes in a large prospective clinical sample. Pain 2016; 157: 1674-1681 doi:10.1097/j.pain.0000000000000569
    CrossrefPubMedSearch in Google Scholar
  • 15 Vaneker M, Wilder-Smith OHG, Schrombges P. et al. Patients initially diagnosed as ‘warm’ or ‘cold’ CRPS 1 show differences in central sensory processing some eight years after diagnosis. A quantitative sensory testing study. Pain 2005; 115: 204-211 doi:10.1016/j.pain.2005.02.031
    CrossrefPubMedSearch in Google Scholar
  • 16 Sandroni P, Benrud-Larson LM, McClelland RL. et al. Complex regional pain syndrome type I. Incidence and prevalence in Olmsted county, a population-based study. Pain 2003; 103: 199-207 doi:10.1016/s0304–3959(03)00065–4
    CrossrefPubMedSearch in Google Scholar
  • 17 De Mos M, de Bruijn AGJ, Huygen FJPM. et al. The incidence of complex regional pain syndrome. A population-based study. Pain 2007; 129: 12-20 doi:10.1016/j.pain.2006.09.008
    CrossrefPubMedSearch in Google Scholar
  • 18 Harden RN, Bruehl S, Perez RSGM. et al. Validation of proposed diagnostic criteria (the “Budapest Criteria”) for Complex Regional Pain Syndrome. Pain 2010; 150: 268-274 doi:10.1016/j.pain.2010.04.030
    CrossrefPubMedSearch in Google Scholar
  • 19 Dimova V, Birklein F. Das komplexe regionale Schmerzsyndrom (CRPS): Ein Update. Der Schmerz 2018; 32: 217-230 doi:10.1007/s00482–018–0287–5
    CrossrefPubMedSearch in Google Scholar
  • 20 Dimova V, Herrnberger MS, Escolano-Lozano F. et al. Clinical phenotypes and classification algorithm for complex regional pain syndrome. Neurology 2020; 94: e357-e367 doi:10.1212/WNL.0000000000008736
    CrossrefPubMedSearch in Google Scholar
  • 21 Birklein F, Drummond PD, Li W. et al. Activation of cutaneous immune responses in complex regional pain syndrome. J Pain 2014; 15: 485-495 doi:10.1016/j.jpain.2014.01.490
    CrossrefPubMedSearch in Google Scholar
  • 22 Parkitny L, McAuley JH, Di Pietro F. et al. Inflammation in complex regional pain syndrome: a systematic review and meta-analysis. Neurology 2013; 80: 106-117 doi:10.1212/WNL.0b013e31827b1aa1
    CrossrefPubMedSearch in Google Scholar
  • 23 He L, Uçeyler N, Krämer HH. et al. Methylprednisolone prevents nerve injury-induced hyperalgesia in neprilysin knockout mice. Pain 2014; 155: 574-580 doi:10.1016/j.pain.2013.12.003
    CrossrefPubMedSearch in Google Scholar
  • 24 Moseley GL, Gallace A, Iannetti GD. Spatially defined modulation of skin temperature and hand ownership of both hands in patients with unilateral complex regional pain syndrome. Brain 2012; 135: 3676-3686 doi:10.1093/brain/aws297
    CrossrefPubMedSearch in Google Scholar
  • 25 Maihöfner C, Handwerker HO, Neundörfer B. et al. Patterns of cortical reorganization in complex regional pain syndrome. Neurology 2003; 61: 1707-1715 doi:org/10.1212/01.WNL.0000098939.02752.8E
    CrossrefPubMedSearch in Google Scholar
  • 26 Pleger B, Tegenthoff M, Ragert P. et al. Sensorimotor retuning (corrected) in complex regional pain syndrome parallels pain reduction. Ann Neurol 2005; 57: 425-429 doi:10.1002/ana.20394
    CrossrefPubMedSearch in Google Scholar
  • 27 Barad MJ, Ueno T, Younger J. et al. Complex regional pain syndrome is associated with structural abnormalities in pain-related regions of the human brain. J Pain 2014; 15: 197-203 doi:10.1016/j.jpain.2013.10.011
    CrossrefPubMedSearch in Google Scholar
  • 28 Maihöfner C, Handwerker HO, Neundörfer B. et al. Cortical reorganization during recovery from complex regional pain syndrome. Neurology 2004; 63: 693-701 doi:org/10.1212/01.WNL.0000134661.46658.B0
    CrossrefPubMedSearch in Google Scholar
  • 29 Sato J, Perl ER. Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury. Science 1991; 251: 1608-1610 doi:10.1126/science.2011742
    CrossrefPubMedSearch in Google Scholar
  • 30 Arnold JM, Teasell RW, MacLeod AP. et al. Increased venous alpha-adrenoceptor responsiveness in patients with reflex sympathetic dystrophy. Ann Intern Med 1993; 118: 619-621 doi:10.7326/0003–4819–118–8-199304150–00008
    CrossrefPubMedSearch in Google Scholar
  • 31 Moseley GL, Zalucki N, Birklein F. et al. Thinking about movement hurts: the effect of motor imagery on pain and swelling in people with chronic arm pain. Arthritis Rheum 2008; 59: 623-631 doi:10.1002/art.23580
    CrossrefPubMedSearch in Google Scholar
  • 32 Llewellyn A, McCabe CS, Hibberd Y. et al. Are you better? A multi-centre study of patient-defined recovery from Complex Regional Pain Syndrome. Eur J Pain 2018; 22: 551-564 doi:10.1002/ejp.1138
    CrossrefPubMedSearch in Google Scholar
  • 33 Beerthuizen A, Stronks DL, Huygen FJPM. et al. The association between psychological factors and the development of complex regional pain syndrome type 1 (CRPS1) – a prospective multicenter study. Eur J Pain 2011; 15: 971-975 doi:10.1016/j.ejpain.2011.02.008
    CrossrefPubMedSearch in Google Scholar
  • 34 Beerthuizen A, van’t Spijker A, Huygen FJPM. et al. Is there an association between psychological factors and the Complex Regional Pain Syndrome type 1 (CRPS1) in adults? A systematic review. Pain 2009; 145: 52-59 doi:10.1016/j.pain.2009.05.003
    CrossrefPubMedSearch in Google Scholar
  • 35 Bean DJ, Johnson MH, Heiss-Dunlop W. et al. Do psychological factors influence recovery from complex regional pain syndrome type 1? A prospective study. Pain 2015; 156: 2310-2318 doi:10.1097/j.pain.0000000000000282
    CrossrefPubMedSearch in Google Scholar
  • 36 Speck V, Schlereth T, Birklein F. et al. Increased prevalence of posttraumatic stress disorder in CRPS. Eur J Pain 2017; 21: 466-473 doi:10.1002/ejp.940
    CrossrefPubMedSearch in Google Scholar
  • 37 Goebel A, Barker C, Birklein F. et al. Standards for the diagnosis and management of complex regional pain syndrome. Results of a European Pain Federation task force. Eur J Pain 2019; 23: 641-651 doi:10.1002/ejp.1362
    CrossrefPubMedSearch in Google Scholar
  • 38 Moseley GL, Herbert RD, Parsons T. et al. Intense pain soon after wrist fracture strongly predicts who will develop complex regional pain syndrome. Prospective cohort study. J Pain 2014; 15: 16-23 doi:10.1016/j.jpain.2013.08.009
    CrossrefPubMedSearch in Google Scholar
  • 39 Jong JR de, Vlaeyen JWS, Onghena P. et al. Reduction of pain-related fear in complex regional pain syndrome type I. The application of graded exposure in vivo. Pain 2005; 116: 264-275 doi:10.1016/j.pain.2005.04.019
    CrossrefPubMedSearch in Google Scholar
  • 40 Oerlemans HM, Oostendorp RA, de Boo T. et al. Adjuvant physical therapy versus occupational therapy in patients with reflex sympathetic dystrophy/complex regional pain syndrome type I. Arch Phys Med Rehabil 2000; 81: 49-56
    CrossrefPubMedSearch in Google Scholar
  • 41 Oerlemans HM, Oostendorp RA, de Boo T. et al. Pain and reduced mobility in complex regional pain syndrome I: outcome of a prospective randomised controlled clinical trial of adjuvant physical therapy versus occupational therapy. Pain 1999; 83: 77-83 doi:10.1016/s0304–3959(99)00080–9
    CrossrefPubMedSearch in Google Scholar
  • 42 McCabe CS, Haigh RC, Blake DR. Mirror visual feedback for the treatment of complex regional pain syndrome (type 1). Curr Pain Headache Rep 2008; 12: 103-107 doi:10.1007/s11916–008–0020–7
    CrossrefPubMedSearch in Google Scholar
  • 43 McCabe CS, Haigh RC, Ring EFJ. et al. A controlled pilot study of the utility of mirror visual feedback in the treatment of complex regional pain syndrome (type 1). Rheumatology 2003; 42: 97-101 doi:10.1093/rheumatology/keg041
    CrossrefPubMedSearch in Google Scholar
  • 44 Cacchio A, Blasis E de, Blasis V de. et al. Mirror therapy in complex regional pain syndrome type 1 of the upper limb in stroke patients. Neurorehabil Neural Repair 2009; 23: 792-799 doi:10.1177/1545968309335977
    CrossrefPubMedSearch in Google Scholar
  • 45 Moseley GL. Imagined movements cause pain and swelling in a patient with complex regional pain syndrome. Neurology 2004; 62: 1644 doi:org/10.1212/01.WNL.0000123019.13575.5E
    CrossrefPubMedSearch in Google Scholar
  • 46 Moseley GL. Graded motor imagery is effective for long-standing complex regional pain syndrome: a randomised controlled trial. Pain 2004; 108: 192-198 doi:10.1016/j.pain.2004.01.006
    CrossrefPubMedSearch in Google Scholar
  • 47 Moseley GL. Is successful rehabilitation of complex regional pain syndrome due to sustained attention to the affected limb? A randomised clinical trial. Pain 2005; 114: 54-61 doi:10.1016/j.pain.2004.11.024
    CrossrefPubMedSearch in Google Scholar
  • 48 Moseley GL. Graded motor imagery for pathologic pain: a randomized controlled trial. Neurology 2006; 67: 2129-2134 doi:10.1212/01.wnl.0000249112.56935.32
    CrossrefPubMedSearch in Google Scholar
  • 49 Johnson S, Hall J, Barnett S. et al. Using graded motor imagery for complex regional pain syndrome in clinical practice: failure to improve pain. Eur J Pain 2012; 16: 550-561 doi:10.1002/j.1532–2149.2011.00064.x
    CrossrefPubMedSearch in Google Scholar
  • 50 Maihöfner C, Speck V. Graded motor imagery for complex regional pain syndrome: where are we now?. Eur J Pain 2012; 16: 461-462 doi:10.1002/j.1532–2149–2011–00106.x
    CrossrefPubMedSearch in Google Scholar
  • 51 George SZ, Wittmer VT, Fillingim RB. et al. Comparison of graded exercise and graded exposure clinical outcomes for patients with chronic low back pain. J Orthop Sports Phys Ther 2010; 40: 694-704 doi:10.2519/jospt.2010.3396
    CrossrefPubMedSearch in Google Scholar
  • 52 den Hollander M, Goossens M, de Jong J. et al. Expose or protect? A randomized controlled trial of exposure in vivo vs pain-contingent treatment as usual in patients with complex regional pain syndrome type 1. Pain 2016; 157: 2318-2329 doi:10.1097/j.pain.0000000000000651
    CrossrefPubMedSearch in Google Scholar
  • 53 Ek J-W, van Gijn JC, Samwel H. et al. Pain exposure physical therapy may be a safe and effective treatment for longstanding complex regional pain syndrome type 1: a case series. Clin Rehabil 2009; 23: 1059-1066 doi:10.1177/0269215509339875
    CrossrefPubMedSearch in Google Scholar
  • 54 Barnhoorn KJ, van de Meent H, van Dongen RTM. et al. Pain exposure physical therapy (PEPT) compared to conventional treatment in complex regional pain syndrome type 1: a randomised controlled trial. BMJ Open 2015; 5: e008283 doi:10.1136/bmjopen-2015–008283
    CrossrefPubMedSearch in Google Scholar
  • 55 Bean DJ, Johnson MH, Heiss-Dunlop W. et al. Extent of recovery in the first 12 months of complex regional pain syndrome type-1. A prospective study. Eur J Pain 2016; 20: 884-894 doi:10.1002/ejp.813
    CrossrefPubMedSearch in Google Scholar