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Int J Sports Med 2021; 42(05): 464-477
DOI: 10.1055/a-1268-8458
Training & Testing

Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice

Dingwen Jiang 
1   The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou
2   Department of Endocrinology, First Affiliated Hospital of Jinzhou Medical University, Jinzhou
,
Chang Liu
2   Department of Endocrinology, First Affiliated Hospital of Jinzhou Medical University, Jinzhou
,
Ye Chen
3   College of Mechanical Engineering and Automation, Liaoning University of Technology, Jinzhou
,
Xuejiao Xing
2   Department of Endocrinology, First Affiliated Hospital of Jinzhou Medical University, Jinzhou
,
Danmeng Zheng
2   Department of Endocrinology, First Affiliated Hospital of Jinzhou Medical University, Jinzhou
,
Zhanpeng Guo
4   Department of Orthopedics, First Affiliated Hospital of Jinzhou Medical University, Jinzhou
,
Sen Lin
4   Department of Orthopedics, First Affiliated Hospital of Jinzhou Medical University, Jinzhou
› Author Affiliations Funding: This work is supported by Youth project of Liaoning Provincial Department of Education of China (Grant No. JYTQN201728) and the project of Liaoning Provincial Department of science and Technology (Grant No. 201602281).
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Abstract

Ageing increases the occurrence and development of many diseases. Exercise is believed to be an effective way to improve ageing and skeletal muscle atrophy. However, many elderly people are unable to engage in active exercise. Whole-body vibration is a passive way of moving that is especially suitable for the elderly and people who find it inconvenient to exercise. Metabolomics is the systematic study of metabolic changes in small molecules. In this study, metabolomics studies were performed to investigate the regulatory effect of whole-body vibration on the skeletal muscles of ageing mice. After 12 weeks, we found that whole-body vibration had the most obvious effect on lipid metabolism pathways (such as linoleic acid, α-linolenic acid metabolism, glycerophospholipid metabolism pathways) in skeletal muscle of ageing mice. Through further research we found that whole-body vibration decreased the levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol and very low-density lipoprotein in blood; decreased the lipid deposition in skeletal muscle; decreased the protein expression of monocyte chemoattractant protein-1 and interleukin-6; improved the protein levels of phosphorylated insulin receptor substrate-1, phosphate phosphoinositide 3-kinase and p-AKT; improved the protein levels of klotho; and decreased the protein expression of p53. These findings reveal that whole-body vibration might postpone senility by attenuating lipid deposition and reducing chronic inflammation and the insulin resistance of skeletal muscle.

Key words

metabolomics - aging - whole body vibration - skeletal muscle - insulin resistance


Publication History

Received: 10 August 2020

Accepted: 09 September 2020

Article published online:
29 October 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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