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CC BY-NC-ND 4.0 · Planta Medica International Open 2020; 07(04): e145-e149
DOI: 10.1055/a-1302-4570
Original Papers

Saikosaponin D Ameliorates Mechanical Hypersensitivity in Animal Models of Neuropathic Pain

Gyeongbeen Lee
1   Biocenter, Gyeonggido Business and Science Accelerator, Suwon, Korea
,
Yeon-Ju Nam
1   Biocenter, Gyeonggido Business and Science Accelerator, Suwon, Korea
,
Woo Jung Kim
1   Biocenter, Gyeonggido Business and Science Accelerator, Suwon, Korea
,
Bo Hye Shin
2   Peripheral Neuropathy Research Center, Dong-A University College of Medicine, Busan, Korea
,
Jong Suk Lee
1   Biocenter, Gyeonggido Business and Science Accelerator, Suwon, Korea
,
Hwan Tae Park
2   Peripheral Neuropathy Research Center, Dong-A University College of Medicine, Busan, Korea
3   Department of Molecular Neuroscience, Dong-A University College of Medicine, Busan, Korea
,
Pansoo Kim
1   Biocenter, Gyeonggido Business and Science Accelerator, Suwon, Korea
,
Ji Hyun Lee
4   Division of Hemato-oncology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea
,
Yongmun Choi
1   Biocenter, Gyeonggido Business and Science Accelerator, Suwon, Korea
› Author Affiliations Funding: This work was supported by the Support Program for Creative Industry Institutes (R0003950, MOTIE, Korea) and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MIST) (NRF-2016R1A5A2007009 and NRF-2017R1C1B5014 853). We would also like to acknowledge the generous financial support from the Gyeonggi provincial government.
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Abstract

We have previously identified saikosaponins as transient receptor potential ankyrin 1 antagonists and showed that saikosaponin D improves neuropathic pain induced by the anticancer drug vincristine in mice. In order to gain more insight into the therapeutic effects of saikosaponin D, we tested saikosaponin D in animal models of neuropathic pain induced by either streptozotocin, which mimics diabetes, or paclitaxel, a commonly used chemotherapy treatment. Our findings indicate that although saikosaponin D improved pain outcomes in neuropathic pain models, the mechanisms underlying the therapeutic effects of saikosaponin D appear to differ between streptozotocin- and paclitaxel-induced pain. Streptozotocin-induced neuropathic pain was significantly alleviated 30 minutes after oral administration of saikosaponin D, while 1-day oral administration of saikosaponin D had little effect on paclitaxel-induced mechanical hypersensitivity. Attenuation of paclitaxel-induced mechanical hypersensitivity was evident only after repeated administration of saikosaponin D. Although the mechanisms underlying the therapeutic effects of saikosaponin D remain to be elucidated, our results shed new light on the therapeutic potential of saikosaponin D in the management of neuropathic pain caused by diabetes or chemotherapy.

Key words

Saikosaponin D neuropathic pain diabetes chemotherapy


Publication History

Received: 09 June 2020
Received: 21 October 2020

Accepted: 29 October 2020

Article published online:
07 December 2020

© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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