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Drug Res (Stuttg) 2021; 71(02): 104-107
DOI: 10.1055/a-1302-7701
Original Article

Development of Composition and Technologies of Dental Film with Ketorolac Trometamine

Elena O. Bakhrushina
1   Sechenov First State Medical University, Moscow, Russia
,
Natalia B. Demina
1   Sechenov First State Medical University, Moscow, Russia
,
Alena S. Kashperko
1   Sechenov First State Medical University, Moscow, Russia
,
Marina G. Vakina
1   Sechenov First State Medical University, Moscow, Russia
,
Maria N. Anurova
1   Sechenov First State Medical University, Moscow, Russia
,
Elena T. Zhilyakova
2   Belgorod State University, Belgorod, Russia
,
Ivan I. Krasnyuk
1   Sechenov First State Medical University, Moscow, Russia
› Author Affiliations Funding This research did not receive any financial support.
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Abstract

The report presents the results of the development of dental films with ketorolac trometamine based on the natural biodegradable polymers from the groups of sodium alginates and xanthan gums in combination with lightly crosslinked acrylic polymer carbopol. Physicochemical properties, such as moisture, mucoadhesion, thickness, tensile strength, disintegration in phosphate buffer were determined in obtained samples of this dosage form. A comparison of physicochemical properties of experimental samples and commercial model of dental film has allowed establishing the perspective composition of complex matrix of films with ketorolac trometamine for use in dentistry.

Keywords

anti-inflammatory drugs - pharmaceutics - drug research - drug delivery


Publication History

Received: 03 October 2020

Accepted: 26 October 2020

Article published online:
18 November 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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