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Endoscopy 2021; 53(08): 815-824
DOI: 10.1055/a-1308-1297
Systematic review

Colon capsule endoscopy in colorectal cancer screening: a systematic review

Fanny E. R. Vuik
1   Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
,
Stella A. V. Nieuwenburg
1   Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
,
Sarah Moen
1   Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
,
Cristiano Spada
2   Digestive Endoscopy and Gastroenterology Unit, Poliambulanza Foundation, Brescia, Italy
3   Digestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli – IRCCS, Catholic University, Rome, Italy
,
Carlo Senore
4   Epidemiology and Screening Unit – CPO, University Hospital Città della Salute e della Scienza, Turin Italy
,
Cesare Hassan
5   Digestive Endoscopy Unit, Nuovo Regina Margherita Hospital, Rome, Italy
,
Marco Pennazio
6   University Gastroenterology Unit, Città della Salute e della Scienza University Hospital, Turin, Italy
,
Emanuele Rondonotti
7   Gastroenterology Unit, Ospedale Valduce, Como, Italy
,
Silvia Pecere
8   Digestive Endoscopy Unit, Fondazione Policlinico Universitario A, Gemelli IRCCS, Roma, Italia
,
Ernst J. Kuipers
1   Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
,
Manon C. W. Spaander
1   Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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Author commentary on Fanny E. R. Vuik et al.Endoscopy 2021; 53(08): v41-v41
DOI: 10.1055/a-1342-1343

Abstract

Introduction Primary colonoscopy and fecal immunochemical test (FIT) are the most commonly used colorectal cancer (CRC) screening modalities. Colon capsule endoscopy (CCE) might be an alternative. Data on the performance of CCE as a CRC screening tool in a screening population remain scarce. This is the first systematic review to provide an overview of the applicability of CCE as a CRC screening tool.

Methods A systematic search was conducted of literature published up to September 2020. Studies reporting on CRC screening by second-generation CCE in an average-risk screening population were included.

Results 582 studies were identified and 13 were included, comprising 2485 patients. Eight studies used CCE as a filter test after a positive FIT result and five studies used CCE for primary screening. The polyp detection rate of CCE was 24 % – 74 %. For polyps > 6 mm, sensitivity of CCE was 79 % – 96 % and specificity was 66 % – 97 %. For polyps ≥ 10 mm, sensitivity of CCE was 84 % – 97 %, which was superior to computed tomographic colonography (CTC). The CRC detection rate for completed CCEs was 93 % (25/27). Bowel preparation was adequate in 70 % – 92 % of examinations, and completion rates varied from 57 % to 92 %, depending on the booster used. No CCE-related complications were described.

Conclusion CCE appeared to be a safe and effective tool for the detection of CRC and polyps in a screening setting. Accuracy was comparable to colonoscopy and superior to CTC, making CCE a good alternative to colonoscopy in CRC screening programs, although completion rates require improvement.

Tables 1s, 2s



Publication History

Received: 15 January 2020

Accepted: 21 October 2020

Article published online:
13 January 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

Refers to:

Role of colon capsule in colorectal cancer screening: lights and shadowsEndoscopy 2021; 53(08): 825-826
DOI: 10.1055/a-1378-8444

 

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