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Nuklearmedizin 2021; 60(02): 106-108
DOI: 10.1055/a-1311-2856
Case Report

Incidental Detections Suggestive of COVID-19 in Asymptomatic Patients Undergoing 68Ga-DOTATATE and 68Ga-PSMA-11 PET-CT Scan for Oncological Indications

COVID-19 Zufallsbefund bei asymptomatischen Patienten mit 68Ga-DOTATATE und 68Ga-PSMA-11 PET-CT-Untersuchung aufgrund onkologischer Indikation
Habibollah Dadgar
1   The Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran
,
Nasim Norouzbeigi
1   The Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran
,
Ali Gholamrezanezhad
2   Department of Radiology, Keck School of Medicine, University of Southern California (USC), 1500 San Pablo Street, Los Angeles, CA 90033 USA
,
Majid Assadi
3   The Persian Gulf Nuclear Medicine Research Center, Department of Molecular Imaging and Radionuclide Therapy, Bushehr Medical University Hospital, Bushehr University of Medical Sciences, Bushehr, Iran
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Incidental Detections Suggestive of COVID-19 in Asymptomatic Patients Undergoing 68Ga-DOTATATE and 68Ga-PSMA-11 PET-CT Scan for Oncological Indications Nuklearmedizin 2021; 60(02): 109-109
DOI: 10.1055/a-1379-4070

Introduction

A novel severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, has emerged in China in December 2019, resulting in an atypical pneumonia called Corona Virus Disease 2019 (COVID-19). The disease has continued to extend globally as the first 21st century pandemic [1]. Despite the suboptimal sensitivity of polymerase chain reaction (RT-PCR) assay, it has been widely considered as the gold standard of diagnosis in the early stages of SARS-CoV-2 infection. Chest computed tomography has been employed in many countries as a substitute or complementary tool for screening/diagnosis, assessment of severity of the disease, and monitoring of response to treatment of COVID-19 pneumonia. It provides higher sensitivity compared to RT-PCR (98 % versus 71 %). In many patients, COVID-19 may present with non-specific respirator and/or constitutional symptoms, such as fever, cough, and dyspnea, while in some others, may remain completely asymptomatic [2] [3] [4] [5] [6] [7].



Publication History

Article published online:
16 December 2020

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  • Reference

  • 1 Lütje S, Marinova M, Kütting D. et al Nuclear medicine in SARS-CoV-2 pandemia: 18F-FDG-PET/CT to visualize COVID-19. Nuklearmedizin 2020; 59 (03) 276-280 . English. doi:10.1055/a-1152-2341. Epub 2020 Apr 7. PMID: 32259853
    Article in Thieme ConnectPubMedGoogle Scholar
  • 2 Albano D, Bertagna F, Bertoli M. et al Incidental Findings Suggestive of COVID-19 in Asymptomatic Patients Undergoing Nuclear Medicine Procedures in a High-Prevalence Region. J Nucl Med 2020; 61 (05) 632-636 . doi:10.2967/jnumed.120.246256. Epub 2020 Apr 1. PMID: 32238429
    CrossrefPubMedGoogle Scholar
  • 3 Huang C, Wang Y, Li X. et al Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395 (10223): 497-506 . doi:10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24. Erratum in: Lancet. 2020 Jan 30. PMID: 31986264; PMCID: PMC7159299
    CrossrefPubMedGoogle Scholar
  • 4 Shi H, Han X, Jiang N. et al Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis 2020; 20 (04) 425-434 . doi:10.1016/S1473-3099(20)30086-4. Epub 2020 Feb 24. PMID: 32105637; PMCID: PMC7159053
    CrossrefPubMedGoogle Scholar
  • 5 Li G, Li W, He X. et al Asymptomatic and Presymptomatic Infectors: Hidden Sources of Coronavirus Disease 2019 (COVID-19). Clin Infect Dis 2020; 71 (08) 2018 . doi:10.1093/cid/ciaa418. PMID: 32271372; PMCID: PMC7184467
    PubMedGoogle Scholar
  • 6 Assadi M, Gholamrezanezhad A, Jokar N. et al Key elements of preparedness for pandemic coronavirus disease 2019 (COVID-19) in nuclear medicine units. Eur J Nucl Med Mol Imaging 2020; 47 (08) 1779-1786 . doi:10.1007/s00259-020-04780-4. PMID: 32318782; PMCID: PMC7171056
    CrossrefPubMedGoogle Scholar
  • 7 Salehi S, Abedi A, Balakrishnan S. et al Coronavirus disease 2019 (COVID-19) imaging reporting and data system (COVID-RADS) and common lexicon: a proposal based on the imaging data of 37 studies. Eur Radiol 2020; 30 (09) 4930-4942 . doi:10.1007/s00330-020-06863-0. Epub 2020 Apr 28. PMID: 32346790; PMCID: PMC7186323
    CrossrefPubMedGoogle Scholar
  • 8 Qin C, Liu F, Yen TC. et al 18F-FDG PET/CT findings of COVID-19: a series of four highly suspected cases. Eur J Nucl Med Mol Imaging 2020; 47 (05) 1281-1286 . doi:10.1007/s00259-020-04734-w. Epub 2020 Feb 22. PMID: 32088847; PMCID: PMC7080035
    CrossrefPubMedGoogle Scholar
  • 9 Deng Y, Lei L, Chen Y. et al The potential added value of FDG PET/CT for COVID-19 pneumonia. Eur J Nucl Med Mol Imaging 2020; 47 (07) 1634-1635 . doi:10.1007/s00259-020-04767-1. Epub 2020 Mar 21. PMID: 32198615; PMCID: PMC7087529
    CrossrefPubMedGoogle Scholar
  • 10 Alberts I, Vollnberg B, Sachpekidis C. et al Incidental SARS-CoV-2-related findings in asymptomatic patients in [18F]-FDG-PET/CT-potential insights. Eur J Nucl Med Mol Imaging 2020; 47 (09) 2068-2069 . doi:10.1007/s00259-020-04869-w. Epub 2020 May 22. PMID: 32444898; PMCID: PMC7244259
    CrossrefPubMedGoogle Scholar
  • 11 Kooraki S, Hosseiny M, Myers L. et al Coronavirus (COVID-19) Outbreak: What the Department of Radiology Should Know. J Am Coll Radiol 2020; 17 (04) 447-451 . doi:10.1016/j.jacr.2020.02.008. Epub 2020 Feb 19. PMID: 32092296; PMCID: PMC7102595
    CrossrefPubMedGoogle Scholar
  • 12 Chefer S, Thomasson D, Seidel J. et al Modeling [(18)F]-FDG lymphoid tissue kinetics to characterize nonhuman primate immune response to Middle East respiratory syndrome-coronavirus aerosol challenge. EJNMMI Res 2015; 5 (01) 65 . doi:10.1186/s13550-015-0143-x. Epub 2015 Nov 16. PMID: 26573211; PMCID: PMC4646887
    CrossrefPubMedGoogle Scholar
  • 13 Martineau P, Kidane B. FDG PET/CT Findings in an Asymptomatic Case of Confirmed COVID-19. Clin Nucl Med 2020; 45 (08) 647-648 . doi:10.1097/RLU.0000000000003145. PMID: 32433160; PMCID: PMC7268853
    CrossrefPubMedGoogle Scholar
  • 14 Playe M, Siavellis J, Braun T. et al FDG PET/CT in a Patient With Mantle Cell Lymphoma and COVID-19: Typical Findings. Clin Nucl Med 2020; 45 (07) e305-e306 . doi:10.1097/RLU.0000000000003113. PMID: 32453077; PMCID: PMC7268867
    CrossrefPubMedGoogle Scholar