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Hamostaseologie 2021; 41(01): 014-021
DOI: 10.1055/a-1325-0993
Review Article

Platelet Shape Changes during Thrombus Formation: Role of Actin-Based Protrusions

Markus Bender
1   Institute of Experimental Biomedicine – Chair I, University Hospital and Rudolf Virchow Center, Würzburg, Germany
,
Raghavendra Palankar
2   Department of Transfusion Medicine, Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany
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Abstract

Platelet activation and aggregation are essential to limit blood loss at sites of vascular injury but may also lead to occlusion of diseased vessels. The platelet cytoskeleton is a critical component for proper hemostatic function. Platelets change their shape after activation and their contractile machinery mediates thrombus stabilization and clot retraction. In vitro studies have shown that platelets, which come into contact with proteins such as fibrinogen, spread and first form filopodia and then lamellipodia, the latter being plate-like protrusions with branched actin filaments. However, the role of platelet lamellipodia in hemostasis and thrombus formation has been unclear until recently. This short review will briefly summarize the recent findings on the contribution of the actin cytoskeleton and lamellipodial structures to platelet function.

Keywords

platelet - thrombus - cytoskeleton - lamellipodia - actin


Publication History

Received: 13 October 2020

Accepted: 28 November 2020

Article published online:
15 February 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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