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Int J Sports Med 2021; 42(10): 889-895
DOI: 10.1055/a-1332-1594
Physiology & Biochemistry

Age-related Decline in Renal Function is Attenuated in Master Athletes

Thiago dos Santos Rosa 
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Hugo Luca Corrêa
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Lucas Pinheiro Barbosa
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Patrick Anderson dos Santos
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Patrício Lopes de Araújo Leite
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Samuel Silva Aguiar 
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Lysleine Alves Deus 
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Larissa Alves Maciel
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Rodrigo Vanerson Passos Neves
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
,
Herbert Gustavo Simoes
Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
› Author Affiliations Funding: We want to thank all individuals that agreed to participate of the study and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior for partially fund our study.
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Abstract

This study analyzed the kidney function and biomarkers of health in lifelong-trained sprinters and endurance runners, and compared them to untrained aged-matched and young controls. Sixty-two men (21–66 yr.) were recruited and allocated as master athletes from sprints (n=25), master athletes from endurance events (n=8), untrained middle-aged (n=14) and young controls (n=15). Participants underwent anamnesis, anthropometric measures and blood sampling for biochemical analyses of klotho, FGF23 and estimated glomerular filtration rate. Master sprinters presented better kidney function in relation to endurance athletes and their untrained peers (P<0.0001). A number of biochemical variables were observed that negatively (i. e., GDF-15, TGF-Beta, IL-18) or positively (i. e., klotho/FGF23 ratio and sestrin-2) correlated with eGFR. Sestrin-2 presented the strongest association with eGFR (r=0.5, P=0.03). Results also revealed that lifelong-trained individuals presented the highest probability of having better values for cystatin C and thus an estimated glomerular filtration rate that was 37–49% higher than untrained peers. Master sprinters presented better kidney function in relation to endurance athletes and middle-aged untrained peers. Sestrin-2 may play a role in exercise-induced kidney function protection.

Key words

klotho - sestrin - FGF-23 - inflammation - oxidative stress - runners


Publication History

Received: 04 June 2020

Accepted: 25 November 2020

Article published online:
08 March 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Kalyani RR, Golden SH, Cefalu WT. Diabetes and aging: Unique considerations and goals of care. Diabetes Care 2017; 40: 440-443
    CrossrefPubMedSearch in Google Scholar
  • 2 Laiteerapong N, Ham SA, Gao Y. et al. The legacy effect in type 2 diabetes: Impact of early glycemic control on future complications (the Diabetes & Aging Study). Diabetes Care 2019; 42: 416-426
    CrossrefPubMedSearch in Google Scholar
  • 3 Najjar SS, Scuteri A, Lakatta EG. Arterial aging: Is it an immutable cardiovascular risk factor?. Hypertension 2005; 46: 454-462
    CrossrefPubMedSearch in Google Scholar
  • 4 Nakayama H, Nishida K, Otsu K. Macromolecular degradation systems and cardiovascular aging. Circ Res 2016; 118: 1577-1592
    CrossrefPubMedSearch in Google Scholar
  • 5 Levey AS, Coresh J. Chronic kidney disease. Lancet 2012; 379: 165-180
    CrossrefPubMedSearch in Google Scholar
  • 6 Levey AS, Eckardt K-U, Tsukamoto Y. et al. Definition and classification of chronic kidney disease: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 2005; 67: 2089-2100
    CrossrefPubMedSearch in Google Scholar
  • 7 Jenny NS. Inflammation in aging: cause, effect, or both?. Discov Med 2012; 13: 451-460
    PubMedSearch in Google Scholar
  • 8 Romano AD, Serviddio G, De Matthaeis A. et al. Oxidative stress and aging. J Nephrol 2010; 23: S29-S36
    PubMedSearch in Google Scholar
  • 9 Kurosu H, Ogawa Y, Miyoshi M. et al. Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 2006; 281: 6120-6123
    CrossrefPubMedSearch in Google Scholar
  • 10 Raj DS, Pecoits-Filho R, Kimmel PL. Inflammation in chronic kidney disease. In: Kimmel P, Rosenberg M. Chronic Renal Disease. 2nd ed.. Amsterdam: Elsevier; 2020: 355-373
    Search in Google Scholar
  • 11 Zhao Y, Banerjee S, Dey N. et al. Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine) 536 phosphorylation. Diabetes 2011; 60: 1907-1916
    CrossrefPubMedSearch in Google Scholar
  • 12 Anatoliotakis N, Deftereos S, Bouras G. et al. Myeloperoxidase: expressing inflammation and oxidative stress in cardiovascular disease. Curr Top Med Chem 2013; 13: 115-138
    CrossrefPubMedSearch in Google Scholar
  • 13 Litvinov D, Mahini H, Garelnabi M. Antioxidant and anti-inflammatory role of paraoxonase 1: implication in arteriosclerosis diseases. N Am J Med Sci 2012; 4: 523–532
    PubMedSearch in Google Scholar
  • 14 Niess A, Dickhuth H, Northoff H. et al. Free radicals and oxidative stress in exercise–immunological aspects. Exerc Immunol Rev 1999; 5: 22-56
    PubMedSearch in Google Scholar
  • 15 Woods JA, Wilund KR, Martin SA. et al. Exercise, inflammation and aging. Aging Dis 2012; 3: 130
    PubMedSearch in Google Scholar
  • 16 Zouhal H, Jabbour G, Jacob C. et al. Anaerobic and aerobic energy system contribution to 400-m flat and 400-m hurdles track running. J Strength Cond Res 2010; 24: 2309-2315
    CrossrefPubMedSearch in Google Scholar
  • 17 Lepers R, Stapley PJ. Master athletes are extending the limits of human endurance. Front Physiol 2016; 7: 613
    CrossrefPubMedSearch in Google Scholar
  • 18 Dubé JJ, Broskey NT, Despines AA. et al. Muscle characteristics and substrate energetics in lifelong endurance athletes. Med Sci Sports Exerc 2016; 48: 472–480
    PubMedSearch in Google Scholar
  • 19 Aguiar SS, Sousa CV, Deus LA. et al. Oxidative stress, inflammatory cytokines and body composition of master athletes: The interplay. Exp Gerontol 2020; 130: 110806
    CrossrefPubMedSearch in Google Scholar
  • 20 Rittweger J, di Prampero PE, Maffulli N. et al. Sprint and endurance power and ageing: An analysis of master athletic world records. Proc Biol Sci 2009; 276: 683-689
    PubMedSearch in Google Scholar
  • 21 Bagley L, McPhee JS, Ganse B. et al. Similar relative decline in aerobic and anaerobic power with age in endurance and power master athletes of both sexes. Scand J Med Sci Sports 2019; 29: 791-799
    CrossrefPubMedSearch in Google Scholar
  • 22 da Silva Aguiar S, Sousa CV, Sales MM. et al. Age-related decrease in performance of male masters athletes in sprint, sprint-endurance, and endurance events. Sport Sci Health 2020; 385-392
    CrossrefPubMedSearch in Google Scholar
  • 23 Harriss DJ, MacSween A, Atkinson G. Ethical standards in sport and exercise science research: 2020 update. Int J Sports Med 2019; 40: 813-817 doi:10.1055/a-1015-3123
    Thieme ConnectPubMedSearch in Google Scholar
  • 24 Pedersen L, Pedersen SM, Brasen CL. et al. Soluble serum klotho levels in healthy subjects. Comparison of two different immunoassays. Clin Biochem 2013; 46: 1079-1083
    CrossrefPubMedSearch in Google Scholar
  • 25 Larsson A, Malm J, Grubb A. et al. Calculation of glomerular filtration rate expressed in mL/min from plasma cystatin C values in mg/L. Scan J Clin Lab Invest 2004; 64: 25-30
    CrossrefPubMedSearch in Google Scholar
  • 26 Cockcroft DW, Gault H. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31-41
    CrossrefPubMedSearch in Google Scholar
  • 27 Kusy K, Zielinski J. Sprinters versus long-distance runners: how to grow old healthy. 2015; 43: 57-64
    PubMedSearch in Google Scholar
  • 28 Calles-Escandon J, Cunningham JJ, Snyder P. et al. Influence of exercise on urea, creatinine, and 3-methylhistidine excretion in normal human subjects. Am J Physiol 1984; 246: E334-E338
    PubMedSearch in Google Scholar
  • 29 Refsum H, Strömme S. Urea and creatinine production and excretion in urine during and after prolonged heavy exercise. Scan J Clin Lab Invest 1974; 33: 247-254
    CrossrefPubMedSearch in Google Scholar
  • 30 Moll K, Gussew A, Nisser M. et al. Comparison of metabolic adaptations between endurance-and sprint-trained athletes after an exhaustive exercise in two different calf muscles using a multi-slice 31P-MR spectroscopic sequence. NMR Biomed 2018; 31: e3889
    CrossrefPubMedSearch in Google Scholar
  • 31 Zieliński J, Slominska EM, Król-Zielińska M. et al. Purine metabolism in sprint-vs endurance-trained athletes aged 20–90 years. Sci Rep 2019; 9: 12075
    CrossrefPubMedSearch in Google Scholar
  • 32 Corrêa HL, Neves RVP, Deus LA. et al. Blood flow restriction training blunts chronic kidney disease progression in humans. Med Sci Sports Exerc 2021;
    CrossrefPubMedSearch in Google Scholar
  • 33 Moraes MR, Rosa TS, Souza MK. et al. Resistance training downregulates macrophages infiltration in the kidney of 5/6 nephrectomized rats. Life Sci 2018; 213: 190-197
    CrossrefPubMedSearch in Google Scholar
  • 34 Souza MK, Neves RVP, Rosa TS. et al. Resistance training attenuates inflammation and the progression of renal fibrosis in chronic renal disease. Life Sci 2018; 206: 93-97
    CrossrefPubMedSearch in Google Scholar
  • 35 Passos CS, Ribeiro RS, Rosa TS. et al. Cardiovascular and renal effects of birdseed associated with aerobic exercise in rats. Med Sci Sports Exerc 2016; 48: 1925-1934
    CrossrefPubMedSearch in Google Scholar
  • 36 Kim M, Sujkowski A, Namkoong S. et al. Sestrins are evolutionarily conserved mediators of exercise benefits. Nat Commun 2020; 11: 190
    CrossrefPubMedSearch in Google Scholar
  • 37 Lee JH, Budanov AV, Park EJ. et al. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 2010; 327: 1223-1228
    CrossrefPubMedSearch in Google Scholar
  • 38 Lee JH, Budanov AV, Karin M. Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metab 2013; 18: 792-801
    CrossrefPubMedSearch in Google Scholar
  • 39 Spada TC, Silva JM, Francisco LS. et al. High intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individuals. PLoS One 2018; 13: e0205791
    CrossrefPubMedSearch in Google Scholar