Es gibt bislang nur wenige Studien, die den Einfluss einer streng kohlenhydratreduzierten, sehr fettreichen, sog. „ketogenen“ Kost auf den Verlauf einer Krebserkrankung untersuchten. Da eine solche Kostform längerfristig Schwierigkeiten bei der Compliance zu Hause bereitet, ist ein supportiver Therapieansatz evtl. sinnvoller, weil er in Anlehnung an Fastenkuren mit den oxidativen Krebstherapien kombiniert werden kann.
5
Kern L,
Mittenbühler MJ,
Vesting AJ.
et al. Obesity-induced TNFalpha and IL-6 signaling: the missing link between obesity and inflammation-driven liver and colorectal cancers. Cancers (Basel) 2018; 11: E24
6
Coyle C,
Cafferty FH,
Vale C.
et al. Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis. Ann Oncol 2016; 27: 2184-2195
9
Hallberg SJ,
McKenzie AL,
Williams PT.
et al. Effectiveness and safety of a novel care model for the management of type 2 diabetes at 1 year: An open-label, non-randomized, controlled study. Diabetes Ther 2018; 9: 583-612
10
Feng S,
Wang H,
Liu J.
et al. Multi-dimensional roles of ketone bodies in cancer biology: Opportunities for cancer therapy. Pharmacol Res 2019; 150: 104500
11
Otto C,
Kaemmerer U,
Illert B.
et al. Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides. BMC Cancer 2008; 8: 122
13
Schmitt M,
Pfetzer N,
Schwab M.
et al. Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial. Nutr Metab 2011; 8: 54
14
Klement RJ,
Champ CE,
Kämmerer U.
et al. Impact of ketogenic diet intervention during radiotherapy on body composition: III–final results of the KETOCOMP study for breast cancer patients. Breast Cancer Res 2020; 22: 94
15
Raffaghello L,
Lee C,
Safdie FM.
et al. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci USA 2008; 105: 8215-8220
16
DeGroot S,
Lugtenberg RT,
Cohen D.
et al. Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nat Commun 2020; 11: 3083
18
Geijer von L,
Ekelund M.
Ketoacidosis associated with low-carbohydrate diet in a non-diabetic lactating woman: a case report. J Med Case Rep 2015; 9: 224
19
Fadini GP,
Bonora BM,
Avogaro A.
SGLT2-Inhibitors and diabetic ketoacidosis: data from the FDA Adverse Event reporting System. Diabetologica 2017; 60: 1385-1389
20
Fieger EI,
Fadel KM,
Modarres AH.
et al. Successful reimplementation of a very low carbohydrate ketogenic diet after SGLT2 Inhibitor associated euglyemic diabetic ketoacidosis. AACE Clinical Case Rep 2020; 6: e330-333
