Download PDF
Osteologie 2021; 30(01): 100-103
DOI: 10.1055/a-1341-4991
Gesellschaftsnachrichten
Informationen der Arbeitsgemeinschaft Knochentumoren e. V.

Diffuse large B-cell lymphoma in and of the bone. Forms and potential precursors

Francesca Spada
,
Thomas Breining
,
Thomas F. E. Barth
,
Peter Möller
› Further Information
Also available at
   Permissions and Reprints

Abstract

Primary diffuse large B-cell lymphoma of the bone (PB-DLBCL) is a rare event and is a diagnosis by exclusion of secondary bone involvement. Here we review the literature regarding PB-DLBCL and give essentials for this diagnosis. Furthermore, we give an overview of potential precursors and discuss chronic recurrent multifocal osteomyelitis (CRMO) as a potential risk factor for PB-DLBCL development in the young.



Publication History

Article published online:
05 March 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 WHO Classification of Tumours Editorial Board: Soft Tissue and Bone Tumours, Lyon (France) International Agency for Research on Cancer; 2020 (WHO Classification of Tumours series, 5th ed; vol. 3). https://publications.iarc.fr/588
  • 2 Bindal P, Desai A, Delasos L. et al. Primary Bone Lymphoma: A Case Series and Review of Literature. Case Rep Hematol 2020; 2020 4254803.
    CrossrefPubMedSearch in Google Scholar
  • 3 Alencar A, Pitcher D, Byrne G. et al. Primary bone lymphoma the university of miami experience. Leuk Lymphoma 2010; 51 (01) : 39-49.
    CrossrefPubMedSearch in Google Scholar
  • 4 Jawad MU, Schneiderbauer MM, Min ES. et al. Primary Lymphoma of Bone in Adult Patients.
    CrossrefPubMed
  • 5 Ramadan KM, Shenkier T, Sehn LH. et al. A clinicopathological retrospective study of 131 patients with primary bone lymphoma: A population-based study of successively treated cohorts from the British Columbia Cancer Agency. Ann Oncol 2007; 18 : 129-135.
    CrossrefPubMedSearch in Google Scholar
  • 6 Czerniak B. Dorfman and Czerniak’s Bone Tumors2nd . Elsevier; 2015. Accessed November 2, 2020. https://www.elsevier.com/books/dorfman-and-czerniaks-bone-tumors/czerniak/978-0-323-02396-2.
    Search in Google Scholar
  • 7 Govi S, Christie D, Messina C. et al. The clinical features, management and prognostic effects of pathological fractures in a multicenter series of 373 patients with diffuse large B-cell lymphoma of the bone. Ann Oncol 2014; 25 (01) : 176-181.
    CrossrefPubMedSearch in Google Scholar
  • 8 Liu Y, Barta SK. Diffuse large B-cell lymphoma: 2019 update on diagnosis, risk stratification, and treatment. Am J Hematol 2019; 94 (05) : 604-616.
    CrossrefPubMedSearch in Google Scholar
  • 9 WHO classification of tumours of haematopoietic and lymphoid tissues. ci.nii.ac.jp. Accessed November 2, 2020. https://ci.nii.ac.jp/naid/20001195667/
  • 10 Alizadeh AA, Elsen MB, Davis RE. et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403 (6769): 503-511.
    CrossrefPubMedSearch in Google Scholar
  • 11 Chapuy B, Stewart C, Dunford AJ. et al. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med 2018; 24 (05) : 679-690.
    CrossrefPubMedSearch in Google Scholar
  • 12 Schmitz R, Wright GW, Huang DW. et al. Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma. N Engl J Med 2018; 378 (15) : 1396-1407.
    CrossrefPubMedSearch in Google Scholar
  • 13 Adams H, Tzankov A, Jundt G. et al. Primary diffuse large B-cell lymphomas of the bone: Prognostic relevance of protein expression and clinical factors B. Hum Pathol 2008; 39(9): 1323–30. doi: 10.1016/j.humpath.2008.01.004.
  • 14 Messina C, Ferreri AJM, Govi S. et al. Clinical features, management and prognosis of multifocal primary bone lymphoma: A retrospective study of the international extranodal lymphoma study group (the IELSG 14 study). Br J Haematol 2014; 164 (06) : 834-840.
    CrossrefPubMedSearch in Google Scholar
  • 15 Wu H, Bui MM, Leston DG. et al. Clinical Characteristics and Prognostic Factors of Bone Lymphomas: Focus on the Clinical Significance of Multifocal Bone Involvement by Primary Bone Large B-Cell Lymphomas BMC Cancer 2014; (14) 900.
    CrossrefPubMed
  • 16 Baecklund E, Backlin C, Iliadou A. et al. Characteristics of diffuse large B cell lymphomas in rheumatoid arthritis. Arthritis Rheum 2006; 54 (12) : 3774-3781.
    CrossrefPubMedSearch in Google Scholar
  • 17 Cheuk W, Chan ACL, Chan JKC. et al. Metallic Implant-Associated Lymphoma. Am J Surg Pathol 2005; 29 (06) : 832-836.
    CrossrefPubMedSearch in Google Scholar
  • 18 Lidgren L. Chronic inflammation, joint replacement and malignant lymphoma. J Bone Jt Surg - Ser B 2008; 90 (01) : 7-10.
    CrossrefPubMedSearch in Google Scholar
  • 19 Sulko J. Diagnostic difficulties: Chronic recurrent multifocal osteomyelitis and lymphoma. One or two diseases?. J Pediatr Orthop Part B 2013; 22 (02) : 170-174.
    CrossrefPubMedSearch in Google Scholar
  • 20 Romero-Rojas AE, Diaz-Perez JA, Raju S. et al. Primary diffuse large B-cell lymphoma associated with chronic osteomyelitis of the knee. Knee 2014; 21 (06) : 1280-1283.
    CrossrefPubMedSearch in Google Scholar
  • 21 Asif S, Abughanimeh OK, Husainat NM. et al. Maxillary Osteomyelitis with an Incidental Diagnosis of Maxillary Diffuse Large B-Cell Lymphoma: A Case Report. Cureus. 2019 11. (7).
    CrossrefPubMedSearch in Google Scholar
  • 22 Senthilvel E, Subbiah S, Jain V. et al. Primary diffuse large B-cell lymphoma of the skull mimicking osteomyelitis. Ear Nose Throat J. 2011 90. (1).
    CrossrefPubMedSearch in Google Scholar
  • 23 Lew DP. Osteomyelitis. thelancet.com 2004; 364 : 369.
    CrossrefPubMedSearch in Google Scholar
  • 24 Rao N, Ziran BH, Lipsky BA. Treating osteomyelitis: Antibiotics and surgery. Plast Reconstr Surg. 2011 127. (SUPPL. 1 S).
    CrossrefPubMedSearch in Google Scholar
  • 25 Bariteau JT, Waryasz GR, McDonnell M. et al. Fungal Osteomyelitis and Septic Arthritis. J Am Acad Orthop Surg 2014; 22 (06) : 390-401.
    CrossrefPubMedSearch in Google Scholar
  • 26 Roderick MR, Shah R, Rogers V. et al. Chronic recurrent multifocal osteomyelitis (CRMO) - advancing the diagnosis. Pediatr Rheumatol 2016; 14: 1 .
    CrossrefPubMedSearch in Google Scholar
  • 27 Meyer zu Reckendorf G, Milon E, Pous JG. Chronic recurrent multifocal osteomyelitis (C.R.M.O.). A case report and review of literature. Eur J Pediatr Surg. 1996; 6 (05) : 312-5.
    Thieme ConnectPubMedSearch in Google Scholar
  • 28 Hofmann SR, Kapplusch F, Girschick HJ. et al. Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment. Curr Osteoporos Rep 2017; 15 (06) : 542-554.
    CrossrefPubMedSearch in Google Scholar
  • 29 CARRA - Childhood Arthritis and Rheumatology Research Alliance. Accessed November 12, 2020. https://carragroup.org/
  • 30 Zhao Y, Wu EY, Oliver MS. et al. Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Anti-Inflammatory Drugs and/or with Active Spinal Lesions HHS Public Access. Arthritis Care Res 2018; 70 (08) : 1228-1237.
    CrossrefPubMedSearch in Google Scholar
  • 31 Hofmann SR, Kubasch AS, Ioannidis C. et al. Altered expression of IL-10 family cytokines in monocytes from CRMO patients result in enhanced IL-1β expression and release. Clin Immunol 2015; 161 (02) : 300-307.
    CrossrefPubMedSearch in Google Scholar
  • 32 Behzadi AH, Raza SI, Carrino JA. et al. Applications of PET/CT and PET/MR Imaging in Primary Bone Malignancies. PET Clin 2018; 13 (04) : 623-634.
    CrossrefPubMedSearch in Google Scholar
  • 33 Kitsoulis P, Vlychou M, Papoudou-Bai A. et al. Primary Lymphomas of Bone. Anticancer Res 2006; 26 : 325-338
    Search in Google Scholar
  • 34 Jellicoe P, Hopyan S. Can chronic recurrent multifocal osteomyelitis predispose to lymphoma of bone? A case report. J Pediatr Orthop B 2008; 17 (06) : 329-332.
    CrossrefPubMedSearch in Google Scholar
  • 35 Hummel M, Oeschger S, Barth FE. et al. Wotherspoon criteria combined with B cell clonality analysis by advanced polymerase chain reaction technology discriminates covert gastric marginal zone lymphoma from chronic gastritis. Gut 2006; 55 : 782-787.
    CrossrefPubMedSearch in Google Scholar