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Synthesis 2021; 53(09): 1636-1644
DOI: 10.1055/a-1343-5642
DOI: 10.1055/a-1343-5642
paper
C2-gem-Aryldifluoromethylation of Quinoline N-Oxides with Potassium 2,2-Difluoro-2-arylacetates under Transition-Metal-Free Conditions
We gratefully acknowledge the National Natural Science Foundation of China (21901081), the Natural Science Foundation of Anhui Province (2008085QB90), and the Excellent Young Talents Fund Program of Higher Education Institutions of Anhui Province, China (gxyq2019167) for financial support.
Abstract
A simple protocol for C2-gem-aryldifluoromethylation of quinoline N-oxides with potassium 2,2-difluoro-2-arylacetates has been developed, affording C2-gem-aryldifluoromethylated quinoline N-oxides bearing different functional groups in moderate to good yields. Moreover, experimental studies reveal that this reaction is likely to proceed through a radical pathway.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1343-5642.
- Supporting Information
Publikationsverlauf
Eingereicht: 13. Dezember 2020
Angenommen nach Revision: 28. Dezember 2020
Accepted Manuscript online:
28. Dezember 2020
Artikel online veröffentlicht:
25. Januar 2021
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22 CCDC 1961422 (3ga) contains the supplementary crystallographic data for this paper. The data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/structures.
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