TumorDiagnostik & Therapie, Table of Contents TumorDiagnostik & Therapie 2021; 42(03): 185-192DOI: 10.1055/a-1352-0216 Schwerpunkt Leukämien Myeloproliferative Neoplasien (MPN) – Update 2020 Kim Kricheldorf , Tim H. Brümmendorf , Steffen Koschmieder Recommend Article Abstract Buy Article Full Text References Literatur 1 Arber DA, Orazi A, Hasserjian R. et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 2016; 127: 2391-2405 2 Koschmieder S, Brümmendorf TH. Myeloproliferative Neoplasien (MPN). klinikarzt 2018; 47: 398-402 3 DGHO. onkopedia-Leitlinien (MPN, PV, ET, PMF). Deutsche Gesellschaft für Hämatologie und Internistische Onkologie (DGHO). Im Internet (Stand: 21.05.2020): https://www.onkopedia.com/de/onkopedia/guidelines 4 Appelmann I, Kreher S, Parmentier S. et al. Diagnosis, prevention, and management of bleeding episodes in Philadelphia-negative myeloproliferative neoplasms: recommendations by the Hemostasis Working Party of the German Society of Hematology and Medical Oncology (DGHO) and the Society of Thrombosis and Hemostasis Research (GTH). Ann Hematol 2016; 95: 707-718 5 Kreher S, Ochsenreither S, Trappe RU. et al. Prophylaxis and management of venous thromboembolism in patients with myeloproliferative neoplasms: consensus statement of the Haemostasis Working Party of the German Society of Hematology and Oncology (DGHO), the Austrian Society of Hematology and Oncology (OGHO) and Society of Thrombosis and Haemostasis Research (GTH e. V.). Ann Hematol 2014; 93: 1953-1963 6 Barbui T, Barosi G, Birgegard G. et al. Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet. J Clin Oncol 2011; 29: 761-770 7 Barbui T, Tefferi A, Vannucchi AM. et al. Philadelphia chromosome-negative classical myeloproliferative neoplasms: revised management recommendations from European LeukemiaNet. Leukemia 2018; 32: 1057-1069 8 Barbui T, Finazzi G, Carobbio A. et al Development and validation of an International Prognostic Score of thrombosis in World Health Organization-essential thrombocythemia (IPSET-thrombosis). Blood 2012; 120: 5128-5133 ; quiz 5252 9 Cervantes F, Dupriez B, Pereira A. et al. New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment. Blood 2009; 113: 2895-2901 10 Gangat N, Caramazza D, Vaidya R. et al. DIPSS plus: a refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status. J Clin Oncol 2011; 29: 392-397 11 Passamonti F, Cervantes F, Vannucchi AM. et al. Dynamic International Prognostic Scoring System (DIPSS) predicts progression to acute myeloid leukemia in primary myelofibrosis. Blood 2010; 116: 2857-2858 12 Tefferi A, Vainchenker W. Myeloproliferative neoplasms: molecular pathophysiology, essential clinical understanding, and treatment strategies. J Clin Oncol 2011; 29: 573-582 13 Kaifie A, Kirschner M, Wolf D. et al. Bleeding, thrombosis, and anticoagulation in myeloproliferative neoplasms (MPN): analysis from the German SAL-MPN-registry. J Hematol Oncol 2016; 9: 18 14 Tefferi A. Primary myelofibrosis: 2017 update on diagnosis, risk-stratification, and management. Am J Hematol 2016; 91: 1262-1271 15 Rumi E, Boveri E, Bellini M. et al. Clinical course and outcome of essential thrombocythemia and prefibrotic myelofibrosis according to the revised WHO 2016 diagnostic criteria. Oncotarget 2017; 8: 101735-101744 16 Barosi G, Mesa RA, Thiele J. et al. Proposed criteria for the diagnosis of post-polycythemia vera and post-essential thrombocythemia myelofibrosis: a consensus statement from the International Working Group for Myelofibrosis Research and Treatment. Leukemia 2008; 22: 437-438 17 Tefferi A, Barbui T. Polycythemia vera and essential thrombocythemia: 2019 update on diagnosis, risk-stratification and management. Am J Hematol 2019; 94: 133-143 18 Passamonti F, Giorgino T, Mora B. et al. A clinical-molecular prognostic model to predict survival in patients with post polycythemia vera and post essential thrombocythemia myelofibrosis. Leukemia 2017; 31: 2726-2731 19 Landolfi R, Marchioli R, Kutti J. et al. Efficacy and safety of low-dose aspirin in polycythemia vera. N Engl J Med 2004; 350: 114-124 20 Cervantes F, Alvarez-Larrán A, Hernández-Boluda JC. et al. Erythropoietin treatment of the anaemia of myelofibrosis with myeloid metaplasia: results in 20 patients and review of the literature. Br J Haematol 2004; 127: 399-403 21 Mesa RA, Steensma DP, Pardanani A. et al. A phase 2 trial of combination low-dose thalidomide and prednisone for the treatment of myelofibrosis with myeloid metaplasia. Blood 2003; 101: 2534-2541 22 Tefferi A, Cortes J, Verstovsek S. et al. Lenalidomide therapy in myelofibrosis with myeloid metaplasia. Blood 2006; 108: 1158-1164