Synthesis of 1,2,3-Triazole-Fused Indole Derivatives via Copper-Catalyzed Cascade Reaction

Kashif Majeed; Bangjie Liu; Fengtao Zhou; Qiuyu Zhang

doi:10.1055/a-1364-9308

Synthesis, Table of Contents

Synthesis 2021; 53(12): 2103-2113
DOI: 10.1055/a-1364-9308

paper

Synthesis of 1,2,3-Triazole-Fused Indole Derivatives via Copper-Catalyzed Cascade Reaction

Authors

Kashif Majeed

^aXi’an Key Laboratory of Functional Organic Porous Materials, Department of Applied Chemistry, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, P. R. of China
Bangjie Liu

^aXi’an Key Laboratory of Functional Organic Porous Materials, Department of Applied Chemistry, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, P. R. of China
Fengtao Zhou∗

^bSchool of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, P. R. of China
Qiuyu Zhang∗

^aXi’an Key Laboratory of Functional Organic Porous Materials, Department of Applied Chemistry, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, P. R. of China

Abstract

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Abstract

A copper-catalyzed tandem reaction has been developed for the synthesis of 1,2,3-triazole-fused indole derivatives. This protocol allowed us to access a wide range of 1,2,3-triazole-fused indole derivatives in moderate to excellent yields. The 1,2,3-triazole-fused indole derivatives emit blue and greenish light when excited at 365 nm. The products were further explored for their quantum efficiency and photophysical properties.

Key words

1,2,3-triazole-fused indoles - [3+2] cycloaddition - C–N bond formation - tandem reaction - sodium azide

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References

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