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Synthesis 2021; 53(12): 2029-2042
DOI: 10.1055/a-1372-6627
DOI: 10.1055/a-1372-6627
short review
Transient- and Native-Directing-Group-Enabled Enantioselective C–H Functionalization
We are grateful for financial support from the Thousand Talents Program for Young Scholars, the Shenzhen Science and Technology Innovation Committee (JCYJ20190809142809370), and the Guangdong Provincial Key Laboratory of Catalysis (2020B121201002).
Abstract
In recent years, transition-metal-catalyzed enantioselective C–H bond functionalization using chiral transient directing groups (cTDGs) or native directing groups (NDGs) has emerged as a powerful and attractive synthetic approach to streamline the synthesis of chiral molecules. This short review focuses on recent advances on imine-based cTDGs strategies and native amine and carboxylic acid directed strategies for the asymmetric functionalization of various C–H bonds. We have endeavored to highlight the great potential of this methodology and hope that this review will inspire further research in this area.
1 Introduction
2 Transient-Directing-Group-Enabled Enantioselective C–H Functionalization
2.1 Generation of Central Chirality
2.2 Generation of Axial Chirality
2.3 Generation of Planar Chirality
3 Native-Directing-Group-Enabled Enantioselective C–H Functionalization
3.1 Native Amines as Directing Groups
3.2 Native Carboxylic Acids as Directing Groups
4 Conclusions and Outlook
Key words
asymmetric catalysis - enantioselective C–H functionalization - transient directing group - native directing group - synthetic methodsPublication History
Received: 12 December 2020
Accepted after revision: 25 January 2021
Accepted Manuscript online:
25 January 2021
Article published online:
15 February 2021
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