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Der Nuklearmediziner 2021; 44(02): 120-126
DOI: 10.1055/a-1380-7815
Aktuelle Trends aus den Radiopharmazeutischen Wissenschaften

Möglichkeiten und Grenzen der Nutzung kleiner Zyklotrone bei der Produktion medizinisch relevanter Radionuklide

Possibilities and limits of use of small cyclotrons for production of medically relevant radionuclides
Bernd Neumaier
Institut für Neurowissenschaften und Medizin, INM-5: Nuklearchemie, Forschungszentrum Jülich GmbH, Jülich
,
Ingo Spahn
Institut für Neurowissenschaften und Medizin, INM-5: Nuklearchemie, Forschungszentrum Jülich GmbH, Jülich
,
Syed M. Qaim
Institut für Neurowissenschaften und Medizin, INM-5: Nuklearchemie, Forschungszentrum Jülich GmbH, Jülich
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Zusammenfassung

Radionuklide für die Bildgebung sowie für die interne Radiotherapie werden in Kernreaktoren sowie an Zyklotronen erzeugt. In diesem Beitrag sollen verschiedene Optionen, Radionuklide an einem kleinen medizinischen Zyklotron (Ep ≤ 18 MeV; Ed ≤ 9 MeV) zu erzeugen, diskutiert werden. Neben der Routineproduktion kurzlebiger „Standard“-Positronenstrahler, wie 11C, 15O und 18F, können auch zahlreiche „Nicht-Standard“-Positronenstrahler, wie 64Cu, 86Y, 89Zr usw., für weitere Anwendungen in der Positronenemissionstomographie (PET) in ausreichender Menge hergestellt werden. Dies setzt voraus, dass ein geeignetes Targetsystem zur Bestrahlung von angereichertem Targetmaterial zur Verfügung steht. Prinzipiell ist es außerdem möglich, einige SPECT-Radionuklide (67Ga, 111In, 123I) sowie Therapienuklide (67Cu, 103Pd, 186Re) in geringen Mengen zu produzieren.

Abstract

Radionuclides for in vivo imaging studies as well as for internal radiotherapy are produced using both nuclear reactors and cyclotrons. In this contribution we discuss the possibilities of production of different types of radionuclides using a small medical cyclotron (Ep  = 18 MeV; Ed = 9 MeV). Besides routine production of short-lived “standard” positron emitters 11C, 15O and 18F, several “non-standard” positron emitters like 64Cu, 86Y, 89Zr etc. could also be produced in quantities sufficient for extended positron emission tomography. It is, however, necessary to develop a suitable target system for irradiation of enriched material. In principle, it is then also possible to produce in small amounts a few SPECT radionuclides (67Ga, 111In, 123I) as well as therapy-related radionuclides (67Cu, 103Pd, 186Re).

Schlüsselwörter

Medizinisches Zyklotron - Positronenstrahler - SPECT- und Therapie-Radionuklide - Kernreaktion und Produktionsausbeute - Fest-, Flüssig- und Gastargets

Keywords

Medical cyclotron - positron emitter - SPECT and therapeutic radionuclides - nuclear reaction and production yield - solid, liquid and gas targets


Publikationsverlauf

Artikel online veröffentlicht:
10. Juni 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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