Die Bedeutung des Elementes Barium in der Nuklearmedizin

Zusammenfassung

Von Erdalkalimetallionen außer Beryllium ist bekannt, dass sie ein calcimimetisches Verhalten zeigen. Damit ist ihr Schicksal in vivo vorgezeichnet, das in einem beträchtlichen Maße durch den Einbau in Knochengewebe, welches zum Hauptteil aus Hydroxylapatit besteht, charakterisiert ist. In diesem Sinne wurde auch die Verwendung von Radionukliden dieser Elemente als Knochensucher forciert. Mit Ausnahme von Beryllium und Magnesium wurden Tierexperimente und Humananwendungen mit Radionukliden von Calcium, Strontium, Barium und Radium durchgeführt, wobei bis heute lediglich Strontium und Radium, in der Hauptsache als Therapienuklide zur palliativen Behandlung von Knochenmetastasen, Eingang in nuklearmedizinische Routineanwendungen gefunden haben. In diesem Übersichtsartikel werden die Radionuklide des Bariums vorgestellt, sowie deren Herstellung und Verwendung. Aktuelle Forschungsergebnisse mit Radionukliden des Bariums in Radiopharmazie und Nuklearmedizin werden präsentiert.

Abstract

The calcimimetic behavior is well known from all alkaline earth metal ions except beryllium. This special characteristic is the reason for their biodistribution which consists of a high incorporation into the bones, based on hydroxyapatite. In this regard, the main application of these radionuclides is based on bone seekers. With exception of the lightest elements beryllium and magnesium, animal experiments and human applications were executed in the past with radionuclides of calcium, strontium, barium, and radium. Today, therapy nuclides of strontium and radium are applied routinely for palliative treatment of bone metastases. This review is focussed on the presentation of barium radionuclides, their preparation and the development of applications in nuclear medicine and radiopharmacy.

Schlüsselwörter

Barium Isotope - Knochensucher - theranostisches Konzept

Keywords

Barium isotopes - bone seeker - theranostic concept

Publikationsverlauf

Artikel online veröffentlicht:
10. Juni 2021

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