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Synthesis 2021; 53(18): 3361-3371
DOI: 10.1055/a-1401-4486
DOI: 10.1055/a-1401-4486
special topic
Bond Activation – in Honor of Prof. Shinji Murai
Intermolecular C–H Amidation of Alkenes with Carbon Monoxide and Azides via Tandem Palladium Catalysis
Autor*innen
We acknowledge financial support from NSFC (21772208, 22001226, 21633013), Natural Science Foundation of Jiangsu Province (BK20201183), Key Research Program of Frontier Sciences of CAS (QYZDJSSW-SLH051), The Natural Science Foundation of the Jiangsu Higher Education Institutions of China (20KJB150016), and Funding for School-Level Research Projects of Yancheng Institute of Technology (xjr2019032).
Abstract
An atom- and step-economic intermolecular multi-component palladium-catalyzed C–H amidation of alkenes with carbon monoxide and organic azides has been developed for the synthesis of alkenyl amides. The reaction proceeds efficiently without an ortho-directing group on the alkene substrates. Nontoxic dinitrogen is generated as the sole by-product. Computational studies and control experiments have revealed that the reaction takes place via an unexpected mechanism by tandem palladium catalysis.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1401-4486.
- Supporting Information (PDF) (opens in new window)
Publikationsverlauf
Eingereicht: 07. Februar 2021
Angenommen nach Revision: 26. Februar 2021
Accepted Manuscript online:
26. Februar 2021
Artikel online veröffentlicht:
29. März 2021
© 2021. Thieme. All rights reserved
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